2007 Akdeniz Üniversitesi 2007 Yılı SCI Yayınlar Akdeniz Üniversitesi Tıp Fakültesi Dekanlığı ŀ İçindekiler TEMEL TIP BİLİMLERİ Anatomi Anabilim Dalı Biyofizik Anabilim Dalı Fizyoloji Anabilim Dalı Histoloji ve Embriyoloji Anabilim Dalı Tıbbi Biyokimya Anabilim Dalı Tıbbi Biyoloji Anabilim Dalı Tıbbi Mikrobiyoloji Anabilim Dalı Tıp Eğitimi Anabilim Dalı DAHİLİ TIP BİLİMLERİ Acil Tıp Anabilim Dalı Aile Hekimliği Anabilim Dalı Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Deri ve Zührevi Hastalıklar Anabilim Dalı Enfeksiyon Hastalıkları Anabilim Dalı Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı Göğüs Hastalıkları Anabilim Dalı Halk Sağlığı Anabilim Dalı İç Hastalıkları Anabilim Dalı Kardiyoloji Anabilim Dalı Nöroloji Anabilim Dalı Radyasyon Onkolojisi Anabilim Dalı Tıbbi Farmakoloji Anabilim Dalı CERRAHİ TIP BİLİMLERİ Beyin ve Sinir Cerrahisi Anabilim Dalı Göğüs Cerrahisi Anabilim Dalı Göz Hastalıkları Anabilim Dalı Kadın Hastalıkları ve Doğum Anabilim Dalı Kulak, Burun ve Boğaz Hastalıkları Anabilim Dalı Ortopedi ve Travmatoloji Anabilim Dalı Plastik ve Rekonstrüktif Estetik Cerrahi Anabilim Dalı Tıbbi Patoloji Anabilim Dalı Üroloji Anabilim Dalı Anatomi Anabilim Dalı - 2007 1-Sarikcioglu L, Arican RY:Wilhelm Heinrich Erb (1840-1921) and his contributions to neuroscience.J Neurol Neurosurg Psychiatry78:(7),732,2007. 2-Yildirim FB, Soyuncu Y, Oguz N, Aydin AT, Sindel M, Ustunel I:Anterior intermeniscal ligament: An ultrastructural study.Annals of Anatomy189:(5), 510-4, 2007. 3-Yildirim FB, Sarikcioglu L:Marie jean pierre flourens (1794-1867): an extraordinary scientist of his time.J Neurol Neurosurg Psychiatry78:(8),852,2007. 4-Sarikcioglu L:Otfrid foerster (1873-1941): one of the distinguished neuroscientists of his time.J Neurol Neurosurg Psychiatry78:(6),650,2007. 5-Sarikcioglu L, Demirel BM, Ozsoy U, Gurer EI, Oguz N, Ucar Y:Angiolipoma located inside the obturator canal and supplied by the umbilical artery.Annals of Anatomy189:(1),75-8,2007. 6-Sarikcioglu L:Johann bernhard aloys von gudden:an outstanding scientist.J Neurol Neurosurg Psychiatry78:(2),195,2007. 7-Sarikcioglu L, Demir N, Demirtop A:A standardized method to create optic nerve crush:Yasargil aneurysm clip.Exp Eye Res.84:(2),373-7,2007. 8-Sarikcioglu L, Duygulu E, Aydin H, Gurer EI,Ozkan O, Tuzuner S:Effects of intrathecal administration of FK506 after sciatic nerve crush J Reconstr Microsurg22:(8),649-54,2006. 9-Coskun N, Karaali K, Cevikol C:Anatomical basics and variations of the scapula in Turkish adultsSaudı Medical Journal 27:(9),1320-5,2006. 10-Sarikcioglu L, Yaba A, Tanriover G, Demirtop A, Demir N, Ozkan O:Effect of severe crush injury on axonal regeneration: a functional and ultrastructural study.J Reconstr Microsurg23:(3),143,2007. ŀ Amyloidogenic transthyretin variant, Gly53Ala 195 4 Blevins G, Macaulay R, Harder S, et al. Oculoleptomeningeal amyloidosis in a 9 Dickson PW, Schreiber G. High levels of messenger RNA for transthyretin large kindred with a new transthyretin variant Tyr69His. Neurology (prealbumin) in human choroid plexus. Neurosci Lett 1986;66:311–15. 2003;60:1625–30. 10 Stangou AJ, Hawkins PN. Liver transplantation in transthyretin-related familial 5 Herrick MK, DeBruyne K, Horoupian DS, et al. Massive leptomeningeal amyloidosis amyloid polyneuropathy. Curr Opin Neurol 2004;17:615–20. associated with a Val30Met transthyretin gene. Neurology 1996;47:988–92. 11 Adams D, Samuel D, Goulon-Goeau C, et al. The course and prognostic factors 6 Mitsuhashi S, Yazaki M, Tokuda T, et al. MRI analysis on a patient with the V30M of familial amyloid polyneuropathy after liver transplantation. Brain mutation is characteristic of leptomeningeal amyloid. Amyloid 2004;11:265–7. 2000;123:1495–504. 7 Munar-Ques M, Salva-Ladaria L, Mulet-Perera P, et al. Vitreous amyloidosis after 12 Ando Y, Terazaki H, Nakamura M, et al. A different amyloid formation liver transplantation in patients with familial amyloid polyneuropathy: ocular mechanism: de novo oculoleptomeningeal amyloid deposits after liver synthesis of mutant transthyretin. Amyloid 2000;7:266–9. transplantation. Transplantation 2004;77:345–9. 8 Schreiber G, Aldred AR, Jaworowski A, et al. Thyroxine transport from blood 13 Ellie E, Camou F, Vital A, et al. Recurrent subarachnoid hemorrhage to brain via transthyretin synthesis in choroid plexus. Am J Physiol associated with a new transthyretin variant (Gly53Glu). Neurology 1990;258(Pt 2):R338–45. 2001;57:135–7. HISTORICAL NOTE .............................................................................................. doi: 10.1136/jnnp.2006.106633 Johann Bernhard Aloys von Gudden: an outstanding scientist ohann Bernhard Aloys von Gudden was a visionary technique of secondary degeneration to study important inter- psychiatrist and neuroanatomist. He dedicated himself to relationships between the cortical and subcortical structures. Jneurobiology and was far more than a consulting psychia- Today, this method, based on retrograde neuronal cell body trist to the Bavarian royal family. Some well-known scientists changes observed after nervous system lesions, is still referred such as Emil Kraepelin (1856–1926), Franz Nissl (1860–1919), to as the von Gudden method. A published article1 shows that Auguste-Henri Forel (1848–1931) and Sigbert Josef Maria he was clearly aware of the limitations of this method; he was Ganser (1853–1931) studied under his supervision. not so much interested in the description of brain centres, but von Gudden was born in Kleve, in lower Rhineland near the was concerned with the independencies and connections Dutch frontier, on 7 June 1824. He was the third of seven sons of between the centres. Johannes Gudden, a landed proprietor, owner of a brewery and Macroscopic observation was widely used in von Gudden’s member of the town council. In 1843, he began his studies in time, as microscopy was still unsatisfactory. Therefore, he philosophy and medicine at the university in Bonn. For his pioneered the development of a microtome, the so-called doctoral dissertation, von Gudden studied torsional eye move- Gudden’s microtome,2 for sectioning the human brain, and ment under the supervision of Alfred Volkman (1800–77) at Halle. using this he described the important neuroanatomical centres. He received his medical degree in 1848 and in the same year His assistant, Auguste-Henri Forel, subsequently improved the passed with distinction the state medical examination in Berlin. microtome, and thus he was able to obtain entire human brain Thereafter, he obtained a position at the Siegburg asylum as an sections, at about 55 mm in thickness. assistant under the supervision of Karl Wigand Maximilian Jacobi von Gudden is perhaps best known for his studies on partial (1775–1858), one of the leading German psychiatrists. decussation of the optic paths, a subject that kept him occupied After completing his studies in Berlin in 1849, von Gudden for around 30 years. His method of producing secondary served in the army for a year. From 1851 to 1855, he worked with atrophy of central structures after the removal of sense organs Christian Friedrich Wilhelm Roller (1802–78) in the Illenau or cranial nerves in young animals ushered in a fresh advance asylum near Achern, the first modern psychiatric hospital in in experimental neurology. In fully grown animals, from which Germany. He married Roller’s granddaughter Clarissa Voigt in eyes had been removed when they were young, he showed not 1855, and, in the summer of the same year at the age of 31, was only crossed and uncrossed optic fibres but also a supraoptic appointed the director of Werneck, a newly established asylum commissure and the transverse peduncular tract. Both of these in northern Bavaria. In October 1869, von Gudden became tracts now bear his name. He was the first to describe the director of the newly founded Burgho¨lzli psychiatric hospital in Zu¨rich, Switzerland, and in 1870, was appointed co-editor of interpeduncular nucleus and the tegmental nuclei, known to all Archiv fu¨r Psychiatry und Nervenkrankheiten. In 1872, he took over who work in the midbrain today as the dorsal and ventral the direction of the Oberbayerische Kreis-Irrenanstalt in nuclei, respectively, of Gudden. Munich, and subsequently became a full professor of psychiatry One of Gudden’s greatest contributions was his observation at the University of Munich. in 1870 that destruction of certain areas of the cerebral cortex At the height of his career, von Gudden was commissioned to leads to atrophy of specific thalamic nuclei. Augustus Volney provide psychiatric care for the Bavarian royal family. He was Waller believed that, after a cut, the cell body and central stump the personal doctor of the mentally diseased Crown Prince of the nerve remained normal, but Gudden found that they Rudolf Otto (1848–1916) for many years. He took responsibility showed signs of atrophy. Accordingly, he launched a series of for the everyday care of the crown prince, who was secluded in investigations in which he used his ‘‘secondary degeneration Furstenried, a castle near Munich, and subsequently was technique’’—that is, the Gudden method—to trace connections assigned to examine and treat King Ludwig II of Bavaria between the main centres of the brain. (1845–86). On 13 July, 2 days after King Ludwig II was arrested Levent Sarikcioglu at Castle Neuschwanstein, Ludwig II and Bernhard von Gudden drowned in Starnberg Lake, close to the castle of Correspondence to: Dr L Sarikcioglu, Department of Anatomy, Akdeniz Berg. The details surrounding their death remain unclear. For University, Faculty of Medicine Campus, Antalya 07070, Turkey; some incomprehensible reason, no autopsy was ever performed [email protected] on von Gudden to determine the cause of death. In the last 14 years of his life, von Gudden devoted himself to References the study of neuroanatomy, a rapidly developing science in the 1 von Gudden JBA. Experimentaluntersuchungen bei das peripherischer und 19th century. He was the first neuroanatomist to create lesions centrale Nervensystem. Arch Psychiatr Nervenkr 1870;2:693–723. in the nervous system of newborn animals and to study the 2 von Gudden B.U¨ber ein neues microtom.