Index A tumor size and weight , 174 ACC. See Adrenal cortical carcinoma (ACC) unilateral tumors , 165 ACTH. See Adrenocorticotropic hormone (ACTH) Adrenal cortical hyperplasia Acute thyroiditis , 14 autosomal dominant disorder , 159 Adenomatoid tumor description , 159 asymptomatic and identifi ed , 204 diffuse cortical cells and focal lipomatous ectopic ACTH production , 160 metaplasia , 205 enlargement , 161 spaces, small glandular , 205 pancreatic neuroendocrine tumor , 160 Adrenal cortical carcinoma (ACC) secondary hyperplasia , 160 aldosteronism , 168 zona fasciculata , 160 alveolar pattern , 169 nodular cellular and nuclear pleomorphism , 167 defi nition , 161 cystic degeneration , 171 endocrine atypia , 162 cytotoxic chemotherapy , 173 macro- and micronodules , 161, 162 description , 173 PPNAD ( see Primary pigmented nodular adrenocortical eosinophilic cells , 167, 168 disease (PPNAD)) eosinophilic cytoplasm , 170, 172, 179, 180 PRKAR1A gene , 159 feminizing/virilizing tumors , 165 Adrenal cysts histologic features , 173 CD31-immunostained sample , 156 insulin-like growth factor 2 , 173 endothelial-lined adrenal cysts , 156 keratin , 181 fi brous-walled adrenal pseudocyst , 156 lipid-rich adrenal cortical adenoma cells , 168 pheochromocytomas , 155 lipofuscin , 171 pseudocysts , 155, 156 lipomatous/myelolipomatous , 167 vague symptoms , 155 lymphoma , 177 Adrenal gland mitotic fi gures , 175 abnormalities and pathogenic processes , 147 multivariate analysis , 165 adipocytes and lymphocytes , 151 myxoid change central adrenal vein , 150 and epithelioid cells , 170 chromaffi n cells , 150 and spindle cells , 170 encapsulated cortical extrusions , 151 necrosis , 175 formalin , 148 nuclear-to-cytoplasmic ratios heterotopia ( see Heterotopia) and cellular monotony , 174 medullary hyperplasia , 147 monotonous cells , 176 pheochromocytomas , 147 mucin , 178 right and left adrenal glands , 148 pleomorphism , 176 scattered adipocyte , 150 oncocytic adenomas , 171 zona pale lipid-rich cell , 166 fasciculata , 149 pale-staining cells , 167 glomerulosa , 148 pediatric tumors , 173 reticularis , 149 polymorphous cells , 176 Adrenal gland tumors primary hyperaldosteronism , 168 adenomatoid , 204–205 pseudoglandular growth pattern , 169 angiosarcoma , 202 pseudoglandular pattern , 177 leiomyosarcoma , 203 punctate microscopic foci , 175 teratoma , 204 small cell cytomorphology , 178 Adrenal medullary hyperplasia spindle cell change , 179 description , 187 spironolactone bodies , 169 MEN2A, MEN2B and cystic subclinical Cushing syndrome , 166 fi brosis , 188 trabecular growth pattern , 176 pheochromocytoma , 188 tumor behavior , 170 trabecular growth pattern , 188 L.A. Erickson, Atlas of Endocrine Pathology, Atlas of Anatomic Pathology, 211 DOI 10.1007/978-1-4939-0443-3, © Springer Science+Business Media New York 2014 212 Index Adrenal myelolipoma colloid , 34 adjacent adrenal cortical tissue , 184 cystic-appearing lymph node metastasis , 36 bilateral , 183 growth patterns , 34 cortical tissue , 184 intranuclear holes , 34 description , 183 invasive , 32 hematopoietic elements , 184 low-power photomicrograph , 35 hypersecretion , 183 multiple ill-defi ned fi rm masses , 32 trilineage hematopoietic cells , 185 “Orphan Annie” nuclei , 32 yellow adipose tissue , 184 papillae with fi brovascular cores and cystic change , 32, 33 Adrenal tumors, metastatic prominent papillae with fi brovascular cores , 32, 33 breast cancer , 209 psammoma bodies , 33 cortical , 207 Columnar variant of PTC , 47 medullary , 207 Composite pheochromocytoma melanoma , 208 composition , 194 neuroendocrine , 207 ganglioneuroma , 194 primary , 207 Cowden syndrome , 25 renal cell carcinoma , 208 Cribriform-morular variant of PTC Adrenocorticotropic hormone (ACTH) aberrant nuclear and cytoplasmic staining, β-catenin , 41 in congenital adrenal hyperplasia , 159 arches and anastomosing bars , 40 cortical hyperplasia , 159 autosomal dominant syndrome , 40 neuroendocrine tumor , 160 morules , 41 Amiodarone thyroid , 5–6 nuclear staining, TTF1 , 41 Amyloid goiter , 25, 28–29 spindle/oval tumor cells , 41 Anaplastic thyroid carcinoma adjacent structures, invasion , 72 atypical spindle cells , 73 D composition , 71, 73 de Quervain thyroiditis. See Granulomatous distant metastases , 71 (de Quervain) thyroiditis hemorrhage and necrosis areas , 72 Diffuse hyperplasia. See Graves disease Hurthle cell carcinoma, dedifferentiation , 74 Diffuse sclerosing variant of PTC , 43 papillary thyroid carcinoma (PTC) , 74–75 Dyshormonogenetic goiter , 27–28 Rhabdoid features , 74 Riedel (fi brous) thyroiditis , 71, 73 TTF1 , 71 F vascular invasion , 72 Familial isolated hyperparathyroidism (FIH) , 131 Angiosarcoma , 92, 202 Fibrous (Riedel) thyroiditis , 13, 16, 71, 73 Atypical parathyroid adenoma FIH. See Familial isolated hyperparathyroidism (FIH) composition , 128 Focal lymphocytic thyroiditis , 13, 18 hypercellular and fi brosis , 128 Follicular adenoma indolent behavior , 128 adipocytes , 57 irregular growth and fi brous bands , 129 clear cell change , 56, 57 Ki67 labeling index , 129 degenerative feature and hyalinization , 59 monotonous growth , 129 description , 55 parathyroid carcinoma , 128 extensive signet ring cell change , 58 immunoperoxidase markers , 56 medium-power view , 59 B metaplastic bone/ossifi cation , 59 Breast cancer , 209 microfollicular and macrofollicular architectural Brown tumor of bone , 113 pattern , 56 mucin , 57 prominent spindle cell change , 58 C signet ring cell change , 58 Calcifi cations , 81 thyroid , 56 Carcinoembryonic antigen (CEA) , 84 Follicular carcinoma Carcinoma showing thymus-like differentiation (CASTLE) , 94–95 capsular invasion , 60 CASTLE. See Carcinoma showing thymus-like clear cell change , 61, 62 differentiation (CASTLE) description , 60 C cells, tumors mushroom-like area , 60 hyperplasia , 78 signet ring cell change , 62 medullary thyroid microcarcinoma , 78–79 spindle cell change , 62 MTC ( see Medullary thyroid carcinoma (MTC)) thrombus , 61 CEA. See Carcinoembryonic antigen (CEA) vascular invasion , 60, 61 Chief cells, parathyroid histology , 103–104 Follicular thyroid neoplasms Classic PTC adenomas ( see Follicular adenoma) cervical and ipsilateral lymph nodes , 35 carcinomas ( see Follicular carcinoma) characteristic cytologic features , 33 cytologic specimens , 55 Index 213 histologic patterns , 55 extracellular eosinophilic hyaline fi brosis , 52 malignancy , 55 prominent eosinophilic intranuclear tumors with extensive vascular invasion , 55 inclusions , 52 Follicular variant of papillary thyroid RET/PTC rearrangements , 51 carcinoma (FVPTC) tumor cells , 52 characteristic features , 38 Hyperparathyroidism–jaw tumor syndrome classic PTC , 37, 39 (HP-JT) , 131 cumulative diagnosis , 37 elongated follicles , 38 encapsulated tumors , 37 L HBME-1 immunostain , 40 Langerhans cell histiocytosis , 91 low-power photomicrograph , 39 Leiomyosarcoma , 203 numerous patterns , 38 Lipoadenomatous hyperplasia , 114 photomicrograph shows , 38 Lipohyperplasia , 109 thyroid parenchyma , 39 Low-grade fi bromyxoid sarcoma , 93 Lymphoma , 90 G Ganglioneuroma M adrenal gland , 198 Medullary thyroid carcinoma (MTC) needle core biopsy , 198 acinar growth pattern , 82 recognizable tumor , 197 amyloid , 79 spindled Schwann cells , 199 calcifi cations , 81 stroma-rich , 198 calcitonin , 83 Granulomatous (de Quervain) thyroiditis CEA , 84 multinucleated giant cells , 15 composition , 81 noncaseating granulomas , 15 epithelioid cells , 80 patchy areas, neutrophils and microabscesses , 14 growth patterns , 80 patients , 13, 14 intranuclear pink holes , 80 Graves disease neuroendocrine markers , 83 complications , 21 oxyphilic , 82 cut section , 22 papillary architectural pattern , 83 diffuse hyperplasia , 23 recognization , 82 diffusely enlarged thyroid , 22 solid growth, necrosis , 81 follicular epithelium , 24 spindle cells , 80 hyperthyroidism , 21 syndromic , 79 low-power photomicrograph , 22 TTF1 , 83, 84 papillae , 22, 23 Metastases to parathyroid patients treatment with iodine , 24 carcinoma , 144 thyroid carcinomas , 21 medullary thyroid carcinoma , 144 thyroid parenchyma , 22 primary thyroid tumors , 143 thyroid tumors , 144 Metastases to thyroid H breast cancer metastatic , 100 Hashimoto thyroiditis melanoma metastatic , 101 fi brous variant , 18 primary tumors , 99 prominent lymphoid follicles , 17 renal cell carcinoma metastatic , 100 solid cell nests , 18 resection , 99 thyroid , 13 Minocycline thyroid , 5–6 H&E. See Hematoxylin and eosin (H&E) MTC. See Medullary thyroid Hematoxylin and eosin (H&E) , 1, 4 carcinoma (MTC) Heterotopia Multinodular goiter , 26–27 adipocytes and foci, lymphocytes , 152 Multiple endocrine neoplasia (MEN) types cortical nodule , 152 1 and 2A , 109 embryologic path , 152 subcapsular space , 152 Hobnail variant of PTC , 48 N HP-JT. See Hyperparathyroidism–jaw tumor Nephrolithiasis , 121 syndrome (HP-JT) Neuroblastoma Hurthle cell adenoma , 63, 64 children , 197 Hurthle cell carcinoma , 65 classifi cation , 197, 199 Hurthle cell thyroid neoplasms , 63–65 ganglion and Schwann cells , 197 Hyalinizing trabecular tumor malignant , 197 Carney’s group , 51 nests , 200 description , 51 primordial neural crest cells , 199 encapsulation and separation , 52 sporadic , 197 214 Index Normal thyroid glandular growth pattern , 135 central lumen containing colloid , 3 hemosiderin deposition , 134 chromogranin immunostain , 4 HRPT2 tumor suppressor gene , 131 cut section , 2 hyperplasia and , 133 fat cells , 4 intrathyroidal , 133 follicles , 3 invasive