our Pleaseonline surveycomplete at NCCN.org/patients/survey NCCN GUIDELINES FOR PATIENTS® 2020 Breast Cancer Metastatic Presented with support from: Available online at NCCN.org/patients Ü Metastatic Breast Cancer It's easy to get lost in the cancer world Let Ü NCCN Guidelines for Patients® be your guide 9 Step-by-step guides to the cancer care options likely to have the best results 9 Based on treatment guidelines used by health care providers worldwide 9 Designed to help you discuss cancer treatment with your doctors NCCN Guidelines for Patients®: Metastatic Breast Cancer, 2020 1 About NCCN Guidelines for Patients® are developed by the National Comprehensive Cancer Network® (NCCN®) NCCN Clinical Practice ® Ü Ü NCCN Guidelines NCCN Guidelines in Oncology ® ® for Patients (NCCN Guidelines ) 9 An alliance of leading 9 Developed by doctors from 9 Present information from the cancer centers across the NCCN cancer centers using NCCN Guidelines in an easy- United States devoted to the latest research and years to-learn format patient care, research, and of experience 9 For people with cancer and education 9 For providers of cancer care those who support them all over the world 9 Explain the cancer care Cancer centers options likely to have the that are part of NCCN: 9 Expert recommendations for best results NCCN.org/cancercenters cancer screening, diagnosis, and treatment Free online at Free online at NCCN.org/patientguidelines NCCN.org/guidelines and supported by funding from NCCN Foundation® These NCCN Guidelines for Patients® are based on the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Breast Cancer (Version 3.2020, March 6, 2020). © 2020 National Comprehensive Cancer Network, Inc. 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NCCN Guidelines for Patients®: Metastatic Breast Cancer, 2020 3 NCCN Guidelines for Patients®: Metastatic Breast Cancer, 2020 4 Metastatic Breast Cancer Contents 6 Breast cancer basics 12 Tests for metastatic breast cancer 24 Treatment options 37 Hormone positive with HER2- 44 Hormone positive with HER2+ 50 Hormone negative with HER2+ 55 Triple-negative breast cancer 59 Making treatment decisions 68 Words to know 71 NCCN Contributors 72 NCCN Cancer Centers 74 Index NCCN Guidelines for Patients®: Metastatic Breast Cancer, 2020 5 1 Breast cancer basics 7 The breast 8 Breast cancer 8 How breast cancer spreads 9 Cancer stages 11 Review NCCN Guidelines for Patients®: Metastatic Breast Cancer, 2020 6 1 Breast cancer basics The breast Metastatic breast cancer is breast Lobules look like tiny clusters of grapes. Small cancer that has spread to other parts tubes called ducts connect the lobules to the of the body. Metastatic breast cancer is nipple. also called stage 4 or advanced breast cancer. The ring of darker breast skin is called the areola. The raised tip within the areola is called the nipple. The nipple-areola complex is a term that refers to both parts. The breast Lymph is a clear fluid that gives cells water and food. It also helps to fight germs. Lymph drains The breast is an organ and a gland found on from breast tissue into lymph vessels and the chest. The breast is made of milk ducts, fat, travels to lymph nodes near your armpit (axilla). nerves, lymph and blood vessels, ligaments, Nodes near the armpit are called axillary lymph and other connective tissue. Behind the breast nodes (ALNs). is the pectoral muscle and ribs. Muscle and ligaments help hold the breast in place. Breast tissue contains glands that can make milk. These milk glands are called lobules. The breast The breast is a glandular organ made Lymph nodes up of milk ducts, Lobules fat, nerves, blood Suspensory Adipose tissue and lymph vessels, ligaments ligaments, and other Lobe Nipple Areola connective tissue. Skin Alveoli Lactiferous duct NCCN Guidelines for Patients®: Metastatic Breast Cancer, 2020 7 1 Breast cancer basics Breast cancer | How breast cancer spreads Breast cancer How breast cancer spreads Breast cancer starts in the cells of the breast. Cancer cells don’t behave like normal cells. Almost all breast cancers are carcinomas. Cancer cells differ from normal cells in the Carcinomas are cancers that start in the cells following ways. that line the inner or outer surfaces of the body. Primary tumor There is more than one type of breast Over time, cancer cells form a mass called a carcinoma. primary tumor. Ductal breast cancer starts in the cells that line the milk ducts. Milk ducts are Invasive thin tubes that carry milk from the lobules Cancer cells can grow into surrounding tissues. of the breast to the nipple. It is the most Invasive breast cancer is breast cancer that has common type of breast cancer. spread from the milk ducts or lobules into the breast tissue or nearby lymph nodes. Lobular breast cancer starts in the lobules (milk glands) of the breast. Metastasis Anyone can have breast cancer, including men. Unlike normal cells, cancer cells can spread Although there are some differences between and form tumors in other parts of the body. men and women, treatment is very similar. Cancer that has spread is called a metastasis. In this process, cancer cells break away from the first (primary) tumor and travel through blood or lymph vessels to distant sites. Once in other sites, cancer cells may form secondary tumors. Cancer that has spread to a nearby body part such as the axillary lymph nodes is called a local metastasis. It might be referred to as local/regional disease or locally invasive or locally advanced. Cancer that has spread to a body part far from the primary tumor is called a distant metastasis. Breast cancer can metastasize to the bones, lungs, liver, spine, or brain. Breast cancer that has metastasized to other parts of the body is still called breast cancer. NCCN Guidelines for Patients®: Metastatic Breast Cancer, 2020 8 1 Breast cancer basics Cancer stages Cancer stages Grade of the cancer (G): How much do the cancer cells look like normal cells? The American Joint Committee on Cancer (AJCC) created a way to determine how much TNM scores cancer is in your body, where it is located, and The tumor, node, metastasis (TNM) system is what subtype you have. This is called staging. used to stage breast cancer. In this system, the Based on testing, your cancer will be assigned letters T, N, and M describe different areas of a stage.