Charalampos Pappas, Ph.D. Curriculum vitae and publication list Charalampos Pappas, Ph.D. University of Freiburg Cluster of Excellence Living, Adaptive and Energy-Autonomous Materials Systems (livMatS) Georges-Kohler-Allee 105 D-79110 Freiburg Phone: +49 01627608434 E-mail: [email protected] Current position University of Freiburg since 10/2020 Junior Research Group Leader Education University of Strathclyde, Glasgow 01/2013-01/2016 Ph.D., Department of Pure and Applied Chemistry Ph.D. Thesis: Supramolecular Systems Chemistry Using Peptides University of Ioannina 09/2010-11/2012 M.Sc., Department of Chemistry and Biochemistry University of Ioannina 09/2005-03/2010 B.Sc., Department of Chemistry and Biochemistry Degree of excellence Research experience University of Groningen 10/2016-10/2020 Stratingh Institute for Chemistry Postdoctoral Marie Skłodowska Curie Fellow with Prof. Sijbren Otto Developed a new research direction on the autonomous emergence of folded macromolecules having the size and complexity of a protein, yet produced from a single monomer. Engineered the spontaneous formation of self-replicating and folded structures using dynamic combinatorial chemistry. City University of New York (CUNY) 01/2016-08/2016 Advanced Science Research Centre (ASRC) Postdoctoral Researcher with Prof. Rein Ulijn Design and fabrication of active soft nanostructures through (bio)catalytic self-assembly. Developed dynamic peptide libraries for the discovery of highly ordered supramolecular nanomaterials based on minimalistic motifs. University of Strathclyde, Glasgow 01/2013-09/2014 Department of Pure and Applied Chemistry Graduate Researcher, with Prof. Rein Ulijn 1 Charalampos Pappas, Ph.D. Curriculum vitae and publication list City University of New York (CUNY) Advanced Science Research Centre (ASRC) 09/2014-01/2016 Graduate Researcher, with Prof. Rein Ulijn Design of minimalistic peptide-based building blocks for the fabrication of supramolecular nanostructures. Synthesis and characterization of the assembly of short peptide amphiphiles forming emulsions. Developed non-equilibrium dissipative systems based on: i) chemical fueling through formation and hydrolysis of tripeptide nanostructures and ii) mechanical energy through the generation of ultrasonic waves. University of Ioannina 09/2010-11/2012 Department of Chemistry and Biochemistry Master thesis conducted with Prof. Andreas Tzakos Thesis: Stereoelectronic control of selective binding of synthetic analogues of Angiotensin II hormone in G- protein receptors AT2/AT1: Structural studies and development of bioactive molecules. Developed binders to GPCR receptors with nM affinity using calorimetric and multidimensional NMR techniques. Scholarships and awards Marie Skłodowska Curie Individual Fellowship (Score 100%) (2017) Human Frontier Science Program Individual Fellowship (top 11%) (2017) Macro Group UK Jon Weaver Ph.D. Prize for the best Ph.D. Thesis in Materials Science (2017) Ian Macmillan Ward Prize for the best publication in Materials Science (2017), Nat. Nanotechnol., 2016, 11, 960-967 Honorable mention (ranked 6th) for IUPAC-SOLVAY international award for young chemists (2017) Second place winner in NanoArtography competition organized by Drexel Nanomaterials Institute (2017) Poster prize award in the conference of Peptide Materials for Biomedicine and Nanotechnology, Italy (2013) Teaching experience University of Groningen 10/2016-10/2020 Teaching assistant for the course of Supramolecular Chemistry for the Master Nanoscience Program University of Strathclyde, Glasgow 01/2013-09/2014 Laboratory assistant in the physical chemistry labs City University of New York (CUNY) 09/2014-08/2016 Teaching assistant for the course of Nanochemistry for the third year Bachelor chemistry program Organization of scientific meetings Two-days international symposium of Active and Adaptive Materials at the Advanced Science Research Centre (ASRC), helping on organization with a total of 120 people (2015) Full-day Super cluster symposium, Centre of Discovery and Innovation at the Advanced Science Research Centre (ASRC), main organization with a total of 60 people (2015) 2 Charalampos Pappas, Ph.D. Curriculum vitae and publication list Reviewing activities Guest co-editor ‘Nanoparticles as Advanced Enzyme Delivery Systems for Therapeutic Applications’ in Frontiers in Chemistry Reviewer of Marie Skłodowska Curie postdoctoral applications Poster judge at Stratingh day, University of Groningen Reviewer in Nature Chemistry, Angewandte Chemie International Edition, Chemical Communications Membership of scientific societies Alumni Marie Curie European Network Royal Society of Chemistry New York Skeptics - scientific member in the origin of life research Outreach Activities “Science of Jelly”, discussing the principles of the self-assembly of amino acids and their role on the formation of hydrogels with high school students and their parents from the UK, University of Strathclyde, Glasgow (2013- 2014) “Advancing public understanding of high-end science”, discussing the use of enzymes as catalysts to trigger the formation of highly ordered supramolecular assemblies with high school students from USA, Advanced Science Research Centre (ASRC) at the City University of New York (2014-2016) Frequent student visits from the most prestigious high schools in Groningen (Pradenius and Willem Lodewijk Gymnasium) discussing the origin of life question (2017-2020) Invited talks (selection) Peptide Systems Chemistry, virtual meeting, EPS Peptide Highlights (invited- July 2021) Spontaneous formation of peptide oligomers, SystemsChemistry virtual meeting (invited- July 2021) Departure from chemical randomness, ChemSystemsMeet, Bohn, Germany (2021) Self-synthesizing peptide based foldamers, CHAINS meeting, Eindhoven, The Netherlands (2019) Emergence of self-replicating and folded assemblies, Science of Early Life Conference, Munich, Germany (2019) Emergence of foldamers from single monomers, Stratingh seminar, Groningen, The Netherlands (2019) Minimalistic dynamic peptide nucleic acid self-replicators, CHAINS meeting, Eindhoven, The Netherlands (2017) Dynamic peptide libraries for the discovery of supramolecular nanomaterials (for the best publication in Materials Science), Swansea, UK (2017) Supramolecular Systems Chemistry using Peptides (for the best Ph.D. Thesis), Birmingham, UK (2017) Pathway selection on biocatalytic self-assembly, Active and Adaptive, Advanced Science Research Centre, New York, USA (2015) Non-equilibrium supramolecular systems, Nanopeptide UK, Technology and Innovation Centre, Glasgow, UK (2015) Funding Ambizione SNSF Individual Grant ETH Zurich (2020) 800,000 € Marie Skłodowska Curie Individual Fellowship (2017) 165,600 € Human Frontier Science Program Individual Fellowship (2017) 152,600 € 3 Charalampos Pappas, Ph.D. Curriculum vitae and publication list Grant funding for Ph.D. research experience in Advanced Science Research Centre (ASRC) at the City University of New York (09/2014-01/2016) 4,000 € Travel grant funding from the Boeringer Foundation (ISMSC2019) 750 € Publications (selection) Total number published = 25, (H-index: 16, citations = 1300, Google Scholar) 1. C. G. Pappas,* B. Liu, I. Marić, J. Ottelé, A. Kiani, M. L. van der Klok, P. R. Onck and S. Otto,* ‘‘Two Sides of the Same Coin: Emergence of Foldamers and Self-Replicators from Dynamic Combinatorial Libraries”, J. Am. Chem. Soc., 2021,143, 7388-7389. 2. C. G. Pappas, P. Mandal, B. Liu, B. Kauffmann, X. Miao, D. Komáromy, W. Hoffmann, C. Manz, R. Chang, K. Liu, K. Pagel, I. Huc* and S. Otto,* “Emergence of Low-Symmetry Foldamers from Single Monomers”, Nat. Chem., 2020, 12, 1180-1186. 3. B. Liu, # C. G. Pappas, # J. Ottelé, G. Schaeffer, C. Jurissek, P. F. Pieters, M. Altay and S. Otto,* “Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids”, J. Am. Chem. Soc., 2020, 142, 9, 4184-4192. Highlighted in New Scientist: Self-replicating molecules may have just two ingredients. 4. C. G. Pappas, #* N. Wijerathne,# J. Kishore Sahoo,# A. Jain, D. Kroiss, I. R. Sasselli, A. Pina, A. Lampel and Rein V. Ulijn* “Spontaneous aminolytic cyclization and self-assembly of dipeptide methyl esters in water”, ChemSystemsChem, 2020, 2, e2000013, DOI: 10.1002/syst.202000013. 5. B. Liu, C. G. Pappas, E. Zangrando, N. Demitri, P. J. Chmielewski and S. Otto,* “Complex Molecules That Fold Like Proteins Can Emerge Spontaneously”, J. Am. Chem. Soc., 2019, 141, 4, 1685-1689. Selected as ACS Editors’ Choice and JACS spotlight: Spontaneous Emergence of Complex Molecules that Can Fold Like Proteins. Highlighted in Chemistry World, Synthetic molecules fold up into abiotic proteins. Highlighted in Chemical & Engineering News, Macrocycle folds up like a protein. Highlighted in Science Daily, Phys. Org, EurekAlert among others. 6. C. G. Pappas, R. Shafi, I. R. Sasselli, H. Siccardi, T. Wang, V. Narang, R. Abzalimov, N. Wijerathne and R. V. Ulijn,* “Dynamic peptide libraries for the discovery of supramolecular nanomaterials”, Nat. Nanotechnol., 2016, 11, 960-967. News and Views entitled “Self-assembly: Materials from a peptide soup”, Nat. Nanotechnol., 2016, 11, 920-921, from Prof. Thomas Hermans. Preview article entitled “Thermodynamic Selection of Supramolecular Nanomaterials from Dynamic Peptide Libraries”, Chem, 2016, 1, 822-829, from Prof. Nicolas Giuseppone. Highlighted in Science Daily, Phys.Org, Nanowerk, The Engineer, Materials Today,