2009 • VOL 9 • SUPPLEMENT 3 American Journal of Transplantation • Volume 9 • Supplement 3 • November 2009 • PP. 1–156 ajt_9_S3-cover 10/8/09 17:16 Page 1 ajt_9_11-mast head 9/24/09 17:57 Page 3 EDITOR-IN-CHIEF OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF TRANSPLANTATION AND THE AMERICAN SOCIETY OF TRANSPLANT SURGEONS Philip F. Halloran, Canada DEPUTY EDITORS Jonathan S. Bromberg, USA Robert L. Fairchild, USA Sandy Feng, USA Bruce Kaplan, USA American Journal of Mark L. Barr, USA John O’Grady, UK EDITORIAL OFFICE Dellice Berezan Gillian Hughes Editorial Office Administrators University of Alberta 250 Heritage Medical Research Centre Edmonton, Alberta T6G 2S02 Phone: +1-780-492-1752 Transplantation Fax: +1-780-407-3417 E-mail:[email protected] DELIVERY TERMS AND LEGAL TITLE Prices include delivery of print journals to the recipient’s address. Delivery terms are Delivered Duty Unpaid (DDU); the recipient is responsible for paying any ASSOCIATE EDITORS import duty or taxes. Legal title passes to the customer on despatch by our distributors. Bryan Becker, USA Emily Blumberg, USA BACK ISSUES J. Andrew Bradley, UK Single issues from current and recent volumes are available at the current single issue price from [email protected]. Earlier issues may be obtained from Daniel Brennan, USA Periodicals Service Company, 11 Main Street, Germantown, NY 12526, USA. Tel: +1 518 537 4700, Fax: +1 518 537 5899, Email: [email protected] David M. Briscoe, USA American Journal of Transplantation, (ISSN 1600-6135), is published monthly on behalf of American Society of Transplantation and the American Society of Ginny L. Bumgardner, USA Transplant Surgeons by Wiley Subscription Services, Inc., a Wiley Company, 111 River St., Hoboken, NJ 07030-5774. Ronald W. Busuttil, USA J. Michael Cecka, USA Periodical Postage Paid at Hoboken, NJ and additional offices. Pierre-Alain Clavien, Switzerland Postmaster: Send all address changes to AMERICAN JOURNAL OF TRANSPLANTATION, Journal Customer Services, John Wiley & Sons Inc., 350 Main St., Robert L. Colvin, USA Malden, MA 02148-5020. Connie Davis, USA PUBLISHER Anthony D’Apice, Australia American Journal of Transplantation is published by Francis L. Delmonico, USA Wiley Periodicals, Inc. 350 Main St. Malden, MA 02148 Thomas Dengler, Germany James D. Eason, USA JOURNAL CUSTOMER SERVICES Henrik Ekberg, Sweden For ordering information, claims and any enquiry concerning your journal subscription please go to interscience.wiley.com/support or contact your nearest office: Robert B. Ettenger, USA Americas: Email [email protected]; Tel: +1 781 388 8598 or 1 800 835 6770 (Toll free in the USA & Canada). Jay Fishman, USA Europe, Middle East and Africa: Email: [email protected]; Tel: +44 (0) 1865 778315 Richard B. Freeman, Jr., USA Asia Pacific: Email: [email protected]; Tel: +65 6511 8000 Alberto Sánchez-Fueyo, Spain INFORMATION FOR SUBSCRIBERS Edward R. Garrity, Jr., USA American Journal of Transplantation is published in 12 issues per year. Institutional subscription prices for 2009 are: Howard M. Gebel, USA Print & Online: US$2139 (US), US$2493 John Gill, Canada (Rest of World), €1615 (Europe), £1272 (UK). Prices are exclusive of tax. Asia-Pacific GST, Canadian GST and European VAT will be applied at the appropriate rates. Ronald G. Gill, USA For more information on current tax rates, please go to www3.interscience.wiley.com/aboutus/journal_ordering_and_payment.html#Tax. The price includes online Josep M. Grinyo, Spain access to the current and all online back files to January 1st 1997, where available. For other pricing options, including access information and terms and conditions, Gregg Hadley, USA please visit www.interscience.wiley.com/journal-info Douglas Hanto, USA PRODUCTION EDITOR Peter S. Heeger, USA Catherine Krendel (email: [email protected]) Benjamin Hippen, USA Hans H. Hirsch, Switzerland ADVERTISING Atul Humar, Canada Eamon Wood (email: [email protected]) Shaf Keshavjee, Canada Commercial reprints: [email protected] Allan D. Kirk, USA This journal is available online at Wiley InterScience. Visit www.interscience.wiley.com to search the articles and register for table of contents e-mail alerts. Goran B. Klintmalm, USA Christophe Legendre, France Access to this journal is available free online within institutions in the developing world through the HINARI initiative with the WHO. For information, visit ChungMau Lo, Hong Kong www.healthinternetwork.org Joaquim Madrenas, Canada Printed in the United States by The Sheridan Press John C. Magee, USA AIMS AND SCOPE Rosalyn Mannon, USA The aim of the American Journal of Transplantation is the rapid publication of new high quality data in organ and tissue transplantation and the related sciences. The Arthur J. Matas, USA journal reflects the field and is an agent for advancing the it through critical reviews and news features, and consensus documents and guidelines. The journal is Herwig-Ulf Meier-Kriesche, USA directed at scientists and clinicians in transplantation but also at those in other fields who wish to follow transplantation. The scope is the international discipline of Michael Mengel, Canada transplantation. This includes organ and tissue donation and preservation; tissue injury, repair, inflammation, and aging; immune recognition, regulation, effector Brian J. Nankivell, Australia mechanisms, and opportunities for induction of tolerance; histocompatibility; drugs and pharmacology relevant to transplantation; graft survival and prevention of José Oberholzer, USA graft dysfunction and failure; clinical trials and population analyses; transplant complications; xenotransplantation; and ethical and societal issues. The sciences Gerhard Opelz, Germany includes relevant aspects of cell biology, medicine, surgery, pediatrics, and infectious diseases. The journal includes thoracic transplantation (heart, lung), abdominal Scott Palmer, USA transplantation (kidney, liver, pancreas, islets), transplantation of tissues and related topics. The American Journal of Transplantation serves as a forum for debate and Tom Pearson, USA reassessment, an agent of change, and a major new platform for promoting understanding, improving results, and advancing science in this dynamic field. Mark D. Pescovitz, USA Rutger J. Ploeg, The Netherlands The Journal is indexed by Chemical Abstracts, CAB Abstracts, CAB health, Science Citation Index Expanded (and therefore the Web of Science), ISI Alerting Heather Ross, Canada Services, Current Contents/Clinical Medicine, EMBASE, the Excerpta Medica database, Elsevier BIOBASE (Current Awareness in Biological Sciences), MEDLINE/ Daniel R. Salomon, USA Index Medicus Millie Samaniego, USA ISSN 1600-6135 (Print) Ron Shapiro, USA Mark D. Stegall, USA ISSN 1600-6143 (Online) Debra L. Sudan, USA For submission instructions, subscription and all other information visit: www.blackwellpublishing.com/ajt Stuart Sweet, USA David O. Taylor, USA Angus Thomson, USA James F. Trotter, USA Yves Vanrenterghem, Belgium Hans-Dieter Volk, Germany Russell H. Wiesner, USA David Wilkes, USA American Society of Transplantation American Society of Transplant Surgeons CONSULTING EDITORS Robert Gentleman, USA MAY 2009 - MAY 2010 MAY 2009 - JUNE 2010 Guiseppe Remuzzi, Italy Jesse Schold, USA PRESIDENT PRESIDENT DISCLAIMER Joren C. Madsen Robert M. Merion The Publisher, American Society of Transplantation and the American Society of Transplant Surgeons, and Editors cannot be held responsible for PRESIDENT-ELECT PAST PRESIDENT errors or any consequences arising from the use of information contained Michael M. Abecassis in this journal; the views and opinions expressed do not necessarily reflect Barbara Murphy those of the Publisher, American Society of Transplantation and the IMMEDIATE PAST PRESIDENT American Society of Transplant Surgeons, and Editors, neither does the publication of advertisements constitute any endorsement by the PRESIDENT-ELECT John P. Roberts Publisher, American Society of Transplantation and the American Society Maryl R. Johnson of Transplant Surgeons, and Editors of the products advertised. PAST PRESIDENT Copyright and Photocopying © 2009 American Society of SECRETARY-TREASURER Goran B. Klintmalm Transplantation and the American Society of Transplant Surgeons. All rights reserved. No part of this publication may be reproduced, stored Robert S. Gaston SECRETARY or transmitted in any form or by any means without the prior Kim M. Olthoff permission in writing from the copyright holder. Authorization to COUNCILORS-AT-LARGE photocopy items for internal and personal use is granted by the TREASURER Maria-Luisa Alegre copyright holder for libraries and other users registered with their local Alan N. Langnas Reproduction Rights Organisation (RRO), e.g. Copyright Clearance Emily A. Blumberg Center (CCC), 222 Rosewood Drive, Danvers, MA 01923, USA Kimberly A. Brown COUNCILLORS-AT-LARGE (www.copyright.com), provided the appropriate fee is paid directly to the RRO. This consent does not extend to other kinds of copying such David J. Cohen Richard B. Freeman as copying for general distribution, for advertising or promotional Michael Green Dixon B. Kaufman purposes, for creating new collective works or for resale. Special Anthony M. Jevnikar requests should be addressed to: [email protected] Timothy L. Pruett Michelle A. Josephson James D. Eason Allan D. Kirk Charles M. Miller Dianne L. LaPointe Rudow Peter G. Stock Roslyn B. Mannon R. Mark Ghobrial Robert S. Higgins EXECUTIVE VICE PRESIDENT Susan J. Nelson Elizabeth
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