IMIM 2019 Trustees Public Funders © Hospital del Mar Medical Research Institute (IMIM) Hospital del Mar Medical Research Institute (IMIM) PRBB Building Dr. Aiguader, 88 08003 Barcelona (Spain) [email protected] www.imim.es Coordination content Marta Calsina, Rosa Manaut September 2020 Summary Introduction . .4 An overview of 2019......................................................6 Scientific Highlights......................................................11 Effectiveness of a new bladder cancer treatment demonstrated..................12 PENSA Project: Analysing whether it is possible to slow down cognitive decline ....14 80% of adult men in Spain will be obese or overweight by the year 2030..........16 Living in a noisy area increases the risk of suffering a more serious stroke . .18 Our own bodies hold the key to designing safer drugs . 20 Mechanism determined for treating the most aggressive tumours ................22 Programmes ............................................................25 Biomedical Informatics....................................................26 Cancer .................................................................42 Epidemiology and Public Health . 90 Inflammatory and Cardiovascular Disorders..................................132 Neurosciences..........................................................198 Facts and Figures .......................................................239 Core Facilities . 240 Internal Services.................................................................. 242 Common Areas and Laboratories.................................................... 246 Internal and External Services . 248 Other Services ................................................................... 256 Research Activity . .259 Scientific Publications ............................................................. 260 Research Grants and Transfer of Results .............................................. 264 Clinical Guidelines ................................................................ 268 Committees ..................................................................... 270 Scientific Advisory Board .......................................................... 276 Management ...........................................................279 Management Structure ............................................................ 280 Income . 282 Human Resources . 287 Quality . 292 Communication . 296 Governing Bodies ................................................................ 305 Introduction Joaquim Bellmunt Jordi Martínez Director IMIM Director IMIM (until August 2019) (from October 2019 to January 2020) 2019 was a year of transition for the management of IMIM. Dr. Joaquim Bellmunt left the position of Director in August, after almost three years, and in early October, Dr. Jordi Martínez temporarily took on the functions of director of the institute until Dr. Joaquin Arribas joined in January 2020. In accordance with the reaccreditation of IMIM as a Healthcare Research Institute at the end of 2018, the Secretary General for Scientific Coordination of the Spanish Ministry of Science, Innovation and Universities also approved changes in the composition of the institute. Thus, in 2019, the foundation BarcelonaBeta Brain Research Center was integrated in the institute and The Genome Regulation Centre (CRG), the Barcelona Global Health Institute (ISGlobal), and the Barcelona Biomedical Research Park Consortium (PRBB), signatories of the Institute’s founding agreement, left the institute. IMIM joined the Catalonia Research Portal (PRC), a portal of the Directorate General for Research of the Catalan government’s Universities and Research Secretariat, which collects, exhibits and disseminates the results of the research produced by Catalan universities and research centers, thus facilitating open access to scientific production. This year saw a greater number of international and EU competitive projects, which has led to a general increase in the institution’s income, among other factors. At the national level, there was a 48% success rate in projects of the Carlos III Institute of Health, a higher percentage than the mean for Spain, which stands at 35%. Also of note was the increase in clinical trials and services contracted for an overall amount of more than 9 million euros. 4 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARY Introduction In terms of ISCIII personal grants, the results for 2019 were exceptional: 3 intensifications, 4 post-residency Río Hortega grants, 3 Sara Borrell post-doctoral grants, 5 Pre-doctoral Training Grants in health research (PFIS), 2 Miguel Servet researcher contracts and 2 Juan Rodés Grants. Activity on transfer of results has continued to increase, with 5 European patents submitted, of which 3 are jointly owned with other centers. A total of 919 scientific publications were produced in 2019, of which 748 are original articles and reviews with an impact factor. The “IMIM Open Access Policy” was also approved this year with the aim of promoting the dissemination of scientific production under open access and in accordance with current national and international law. Open access aims to achieve permanent, free and unrestricted access to scientific and academic content with the aim of encouraging visibility, dissemination and socialization of knowledge. The 2018-2021 2nd Equal Opportunities Plan for men and women was approved by the Management Commission and the Board of Governors of the IMIM Foundation in June 2019 and was drafted and agreed by an equality commission made up of equal numbers of male and female representatives of the employees and of the institution. Furthermore, IMIM has signed the letter of commitment to equality in medical research in Catalonia, in the framework of the first Gender in Health Sciences Summit, organized by the Catalan Health Care Quality and Evaluation Agency (AQuAS) and the Department of Health of the Catalan Autonomous Government, in collaboration with the Foundation “la Caixa” with the aim of ending gender inequality in the research system in Catalonia. In 2019, IMIM was mentioned in the media in a total of 2310 news items. The number of impacts was 20% higher than the previous year. Of note was the success of the press release “80% of the adult population in Spain will present obesity or be overweight by the year 2030”, with 411 mentions in the press. From July to November 2019, the Ciutadella-Vila Olímpica metro held the exhibition “Leonardo da Vinci at the PRBB”, organized jointly by all the PRBB centers. The aim of the exhibition was to provide a graphic vision of human biology while commemorating the 500th anniversary of the death of Leonardo da Vinci (1452-1519). The leitmotiv of the exhibit, “from macro to micro”, followed the profile of the research carried out in the PRBB centers, where the different aspects of biomedicine are studied in all areas and at all levels. > SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 5 An overview of 2019 € 55 21 M€ 719 Research Income Professionals groups 212 748 Research Original articles and reviews projects with IF (59% First quartile) 46 Doctoral Theses Read 28 2,310 Awards Items Recorded in the Media 6 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARY An overview of 2019 Programmes 5 Biomedical Cancer Epidemiology and Informatics 12 Groups Public Health 4 Groups 9 Groups 1 Associated 1 Associated Inflammatory and Neurosciences Cardiovascular Disorders 8 Groups 15 Groups 5 Associated Personnel 719 Researchers PhD Students Technicians Support 372 59 209 79 51% women 75% women 73% women 81% women 49% men 25% men 27% men 19% men > SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 7 An overview of 2019 Current competitive projects by funding institution National 84.9% (180) Other 7.08% International WADA 2.83% European 15.1% (32) Union 5.19% Other 18.87% ISCII 40.57% Generalitat de Catalunya 1.42% Departament de Salut 7.55% Agencia Estatal de Investigación 7.08% Fundación Mutua Madrileña 0.47% La Caixa 1.42% COIB 1.42% Ministerio de Sanidad 0.94% AEEC 2.36% La Marató 2.83% Projects by programme 212 17 43 38 57 53 Biomedical Cancer Epidemiology Inflammatory Neurosciences Informatics and Public and Health Cardiovascular Disorders Other: 4 8 IMIM 2019 Hospital del Mar Medical Research Institute > SUMMARY An overview of 2019 Publications by programme 919 29 179 258 318 135 Biomedical Cancer Epidemiology Inflammatory Neurosciences Informatics and Public and Health Cardiovascular Disorders Publications with international collaboration + than 50 between 21 between 10 - than 10 and 50 and 20 > SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 9 Scientific Highlights > Effectiveness of a new bladder cancer treatment demonstrated > PENSA Project: Analysing whether it is possible to slow down cognitive decline > 80% of adult men in Spain will be obese or overweight by the year 2030 > Living in a noisy area increases the risk of suffering a more serious stroke > Our own bodies hold the key to designing safer drugs > Mechanism determined for treating the most aggressive tumours > SUMMARY IMIM 2019 Hospital del Mar Medical Research Institute 11 Scientific Highlights Effectiveness of a new bladder cancer treatment demonstrated It involves an inhibitor of a dual protein, mTORC1/2, which is key in tumour growth Researchers from the Molecular Cancer group at the Hospital del Mar Medical Research Institute (IMIM) and doctors from Hospital del Mar, have demonstrated