汉阳大学 2015年度中国留学生招生 教授及研究室简介 2015 Applicants Laboratory List Hanyang University ERICA Campus NO. Name Department Name of Laboratory Page 1 Ahn, Seong-hoon BIO Molecular & Life Science Molecular Cell Biology Laboratory 1 2 Bert Binas BIO Molecular & Life Science Stem Cell Laboratory 4 3 Bang, Jin-ho Applied Chemistry Nanomaterial synthesis Laboratory 6 4 Chun, Hyung-phil Applied Chemistry Molecular Solids Laboratory 11 Electronics & System Ubiquitous Network 5 Hong, Seung-ho 13 Engineering Systems Laboratory Electronics and Wireless Communications 6 Jin, Hu 18 Communication Engineering Systems Laboratory Electronics & System Energy Transform System 7 Kwon, Byung-il 20 Engineering Laboratory construction materials & building 8 Lee, Han-seung Architectural Engineering 24 Laboratory Electronics & Communication 9 Shin, Hyun-chul Digital System Laboratory 26 Engineering Sustainable Building Evaluation 10 Tae, Sung-ho Architectural Engineering 30 Special Technology Lab 11 Yoon, Joon-yong Mechanical Engineering Fluid Engineering LAB 34 12 Yoon, Jong-hun Mechanical Engineering CHAMP Lab 36 PROFESSOR INFORMATION OF HANYANG UNIVERSITY ≫ BASIC INFO. NAME Ahn, Seong-Hoon 中文姓名 TELEPHONE 031-400-5518 FAX NO. 031-400-5457 NO. E-MAIL [email protected] HOMEPAGE www.mcblab.net ≫ EDUCATIONAL BACKGROUND B.S: Sungkyunkwan University, 1996 M.S.: Sungkyunkwan University, 1998 Ph.D.: Sungkyunkwan University, 2001 ≫ EXPERIENCE 2001 – 2005, Post-Doc. (Harvard Medical School, BCMP, PI: Stephen Buratowski). 2005 – 2010, Assistant Professor (Hanyang University at ERICA campus) 2010 – present, Associate Professor (Hanyang University at ERICA campus) ≫ RESEARCH INTERESTS Our research addresses the mechanism of gene transcription by epigenetic histone modifications in eukaryotes. Our lab currently works on histone methylation, ubiquitylation, and acetylation with their relationships with the phosphorylations within RNA polymerase II C-terminal domain and the regulation of cellular lifespan. ≫ ON-GOING RESEARCH PROJECTS 1. Regulation of cellular lifespan by phosphorylation of RNA polymerase II and histone modification (2014 년도 ERICA 캠퍼스 포닥 채용지원사업) 2. Regulation of gene transcription by epigenetic histone modifications (2014 년도 선도연구센터지원사업) 3. Molecular Mechanism For Transcription Activation And Telomeric Silencing By COMPASS and Histone Lysine Demethylases (2014 년도 중견연구자지원사업 핵심연구) ≫ RESEARCH PAPERS(INCLUDING SCI JOURNAL PUBLICATIONS) [IF = 7.43] Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic rDNA condensation. Ryu HY, Ahn SH. BMC Biology. 2014 (in press). [IF = 2.484] Loss of the Set2 histone methyltransferase increases cellular lifespan in yeast cells. Ryu HY, Rhie BH, Ahn SH. Biochem Biophys Res Commun. 2014 Mar 28 446(1):113–118 [IF = 2.484] The RNA polymerase II Rpb4/7 subcomplex regulates cellular lifespan through an mRNA decay process. Duan R, Rhie BH, Ryu HY, Ahn SH. Biochem Biophys Res Commun. 2013 Nov 8 441(1):266-270. 1 [IF = 2.484] Cellular aging is associated with increased ubiquitylation of histone H2B in yeast telomeric heterochromatin. Rhie BH, Song YH, Ryu HY, Ahn SH. Biochem Biophys Res Commun. 2013 Oct 4;439(4):570-575. [IF = 2.648] Role of yeast JmjC-domain containing histone demethylases in actively transcribed regions. Kwon DW, Ahn SH. Biochem Biophys Res Commun. 2011 Jul 8;410(3):614-9. [IF = 2.648] IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II. Park JH, Ahn SH. Biochem Biophys Res Commun. 2010 Feb 19;392(4):588-592. [IF = 5.520] A Bre1-associated Protein, Large 1 (Lge1), Promotes H2B Ubiquitylation during the Early Stages of Transcription Elongation. Song YH, Ahn SH. J Biol Chem. 2010 Jan 22;285(4):2361-7. [IF = 8.295] Ctk1 promotes dissociation of basal transcription factors from elongating RNA polymerase II. Ahn SH*, Keogh MC, Buratowski S. *Corresponding author EMBO J. 2009 Feb 4;28(3):205-12. Epub 2009 Jan 8. [IF = 5.520] Reversine Increases the Plasticity of Lineage-committed Cells toward Neuroectodermal Lineage. Lee EK, Bae GU, You JS, Lee JC, Jeon YJ, Park JW, Park JH, Ahn SH, Kim YK, Choi WS, Kang JS, Han G, Han JW. J Biol Chem. 2009 Jan 30;284(5):2891-901. [IF = 7.216] Histone deacetylase inhibitor apicidin downregulates DNA methyltransferase 1 expression and induces repressive histone modifications via recruitment of corepressor complex to promoter region in human cervix cancer cells. You JS, Kang JK, Lee EK, Lee JC, Lee SH, Jeon YJ, Koh DH, Ahn SH, Seo DW, Lee HY, Cho EJ, Han JW. Oncogene. 2008 Feb 28;27(10):1376-86. [IF = 2.648] PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells. Eun DW*, Ahn SH*, You JS, Park JW, Lee EK, Lee HN, Kang GM, Lee JC, Choi WS, Seo DW, Han JW. *Equally contributed 1st authors Biochem Biophys Res Commun. 2007 Mar 16;354(3):769-75. Epub 2007 Jan 17. [IF = 31.253] Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Keogh MC, Kurdistani SK, Morris SA, Ahn SH, Podolny V, Collins SR, Schuldiner M, Chin K, Punna T, Thompson NJ, Boone C, Emili A, Weissman JS, Hughes TR, Strahl BD, Grunstein M, Greenblatt JF, Buratowski S, Krogan NJ. Cell. 2005 Nov 18;123(4):593-605. [IF = 8.295] Transitions in RNA polymerase II elongation complexes at the 3' ends of genes. Kim M, Ahn SH, Krogan NJ, Greenblatt JF, Buratowski S. EMBO J. 2004 Jan 28;23(2):354-64. 2 [IF = 12.903] Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processing. Ahn SH, Kim M, Buratowski S. Mol Cell. 2004 Jan 16;13(1):67-76. [IF = 5.942] RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach. Krogan NJ, Kim M, Ahn SH, Zhong G, Kobor MS, Cagney G, Emili A, Shilatifard A, Buratowski S, Greenblatt JF. Mol Cell Biol. 2002 Oct;22(20):6979-92. [IF = 5.520] Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells. Kwon SH, Ahn SH, Kim YK, Bae GU, Yoon JW, Hong S, Lee HY, Lee YW, Lee HW, Han JW. J Biol Chem. 2002 Jan 18;277(3):2073-80. Epub 2001 Nov 6. [IF = 5.520] Activation of p21(WAF1/Cip1) transcription through Sp1 sites by histone deacetylase inhibitor apicidin: involvement of protein kinase C. Han JW*, Ahn SH*, Kim YK, Bae GU, Yoon JW, Hong S, Lee HY, Lee YW, Lee HW.*Equally contributed 1st authors J Biol Chem. 2001 Nov 9;276(45):42084-90. Epub 2001 Sep 10. [IF = 7.514] Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Han JW*, Ahn SH*, Park SH, Wang SY, Bae GU, Seo DW, Kwon HK, Hong S, Lee HY, Lee YW, Lee HW. *Equally contributed 1st authors Cancer Res. 2000 Nov 1;60(21):6068-74. ≫ OTHER INTERNATIONAL ACTIVITIES We have been working on the topic, ‘epigenetic regulation of gene expression’ for more than 20 years. If you are interested in ‘Epigenetics’, ‘Transcription’, or ‘Aging’, you may perform a lot of experiments here using a variety of biochemical or molecular biological techniques and I hope you can achieve your research goal by publishing many SCI journals with good impact factor. There is one graduate student (MS-PhD combined course), Ruxin Duan, from China in my lab. If you have any questions, please email to me or directly to her ([email protected]). 3 PROFESSOR INFORMATION OF HANYANG UNIVERSITY ≫ BASIC INFO. NAME Binas, Bert 中文姓名 TELEPHONE NO. +82-31-400-5517 FAX NO. +82-31-419-1760 E-MAIL [email protected] HOMEPAGE www.hanyang.ac.kr ≫ EDUCATIONAL BACKGROUND - Ph.D., Cellular Biochemistry, Central Institute of Molecular Biology, Berlin, Germany, 1987 - Diploma, Biophysics, 2nd Medical Institute Moscow, Russia, 1981 ≫ EXPERIENCE Positions: - Professor, College of Science and Technology, Hanyang University, 2008-present - Associate Professor, Texas A&M University, USA, 2000-2008 - Scientist, Max Delbruck Center for Molecular Medicine, Berlin, Germany, 1995-2000 - Higher scientific officer, Roslin Institute Edinburgh, Scotland, 1992-1994 - Staff scientist, Central Institute for Molecular Biology, Berlin, Germany, 1981-1991 Visiting Scholarships: - Univ. of Leuven, Belgium, Jan/Feb 2010 (host: Prof. C. Verfaillie) - Univ. of North Carolina at Chapel Hill, USA, June/July 2002 (host: Prof. O. Smithies) - Yale University, USA, May/June 2000 (host: Prof. G. Shulman) ≫ RESEARCH INTERESTS - Biology and medical application of the stem cells that occur in pre-implantation embryos and early post-implantation embryos ≫ ON-GOING RESEARCH PROJECTS - Role of the transcription factor Oct4 in the self-renewal and differentiation of hypoblast stem cells - Plasticity (trans-specification, trans-differentiation) of hypoblast stem cells - Novel stem cell isolations ≫ RESEARCH PAPERS(INCLUDING SCI JOURNAL PUBLICATIONS) 4 10 papers selected from my publication list: - Binas B, Verfaillie CM. Bone marrow meets blastocyst: Lessons from an unlikely encounter. Stem Cells 31(4):620-6, 2013. - Han D, Binas B. Monoallelic gene targeting in hypoblast stem cells reveals X chromosome inactivation. Biochem Biophys Res Commun. 427(3):563-7, 2012. - Debeb BG, Galat V, Epple-Farmer J, Iannaccone S, Woodward WA, Bader M, Iannaccone P, Binas B. Isolation of Oct4-Expressing Extraembryonic Endoderm Precursor Cell Lines. PLoS One 4(9):e7216, 2009. - Epple-Farmer J, Debeb B, Smithies O, Binas B. Gender-dependent survival of allogeneic trophoblast stem cells in liver. Cell Transplantation 18(7):769-76, 2009. - Binas B. Embryo-derived stem cells-a system is emerging. BMB Reports 42(2):72-80, 2009. - Binas B, Erol E. FABPs as determinants of myocellular and hepatic fuel metabolism. Molecular and Cellular Biochemistry 299(1-2):75-84, 2007. - Erol E, Kumar LS, Cline GW, Shulman GI, Kelly DP, Binas B. Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha.