Research Article AdvancementJournal of Cancer in Genetic Science Engineering and Research GeneticallyThe effect of Engineered Auriculotherapy Biomaterials in the Control of Chemotherapy-Induced Nau- SinithRashminsea and Vomiting Withanage in* ,Women Kladko Daniil with Breast Cancer Mitra Reyhani Ph.D.1* Seyedeh Aghaghia Reza Tofighi BS2* ITMO University, SCAMT Laboratory, Saint Petersburg, 191002, Russian Federation 1Department of Midwifery, School of Allied Medical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. 2Department of Nursing and Midwifery, Besat oil and Gas hospital, Gachsaran, Iran ABSTRACT The involvement of genetic engineering techniques in the development of novel biomaterials has a huge impact on a vastAbstract range of applications. The capability of new genetically engineered material has achieved various innovative scopesChemotherapy-induced in the biomedical nausea industry. and Such vomiting materials (CINV) are isusually one of designed the most viacommon chemical and and feared physical side effects methods of chemotherapy of genetic engineering.especially in breastAccording cancer. to Despitethe genetic recent basis advances of sequence, in pharmacologic molecular antiemeticweight, folded therapy, structure, additional and treatmentstereochemistry, for break- through CINV is needed. Auriculotherapy, is a safe alternative medicine procedure with minimal side effects; several ran- protein polymers thus suggest a generous view for the architecture of protein-based genetically engineered domized controlled clinical trials have suggested its efficacy in controlling this side effect. A recent randomized controlled biomaterials.clinical trial in Iran , demonstrated that Auriculotherapy, significantly reduced the proportion of patients experiencing Theacute scopes stress ofand developing vomiting genetically during IVF. engineered That trial, biomaterials however, did are not leading show to that improve Auriculotherapy, biological features significantly of materials alleviated whichacute chemotherapy-inducedcan enhance the applicability nausea and or delayed properties CINV. of materials. The clinical In relevancethe last five of years,these resultsGenetic were engineering limited by research the fact isthat they predated the use of aprepitant and that only few Auriculotherapy points were stimulated during Auriculotherapy, becoming closer to the mass consumer. Leading global geneticists predict that in the coming years, a boom will occur treatment. More clinical trials to study the effect of acupuncture with additional antiemetic acupuncture points in ad- injunct the togenetic modern engineering pharmacologic market, antiemetic comparable therapy to arethe needed.massive Chemotherapy-inducedspread of personal computers nausea andin thevomiting 1980s. (CINV) Thus is geneticallyone of the mostmodified common biomaterials and feared with treatment-related upgraded biological side effects properties, among patients expanding with cancertowards especially mass-scale in breast industrial cancer . production,Over the past and decade, the considerable better understanding consumption of the in regularphysiology universal of CINV activities. and subsequent development of modern pharma- cologic antiemetic agents have substantially improved the control of CINV. However, a study suggests that CINV remains The techniques used to develop new materials and to modify the properties of existing materials, are subjected to a significant problem among these patients.2 In addition, pharmacologic antiemetic agents are expensive and associated differentwith potential industries side effects,and fields and thereforeof scientific exploring researches. nonpharmacologic CRISPR is anoptions authoritative for controlling research CINV tool is thatimportant. facilitates Auric- scientistsulotherapy, to dealis an with Chinese the expression, europian medicalof a gene. technique It has shown proven tremendous to be effective potential and safe in ingenome treating research multiple due conditions, to its abilityincluding to delete nausea unwanted and vomiting traits, caused and possiblyby pregnancy,3 even replace sea sickness,4 them with surgery,5 desirable and traits.chemotherapy.6 It is agile, worthwhile, and moreKeywords: authentic Auriculotherapy, than any preceding electrostimulation, gene-editing chemotherapy, techniques. nausea,Genetically vomiting engineered biomaterials have been an enormous field of research over the last fifteen years and CRISPR has already initiated performing a significant aspect in boosting biomaterial research. Introduction have side effects such as mood disturbances and drowsiness [8]. Keywords: Genetic engineering; CRISPR; Biotechnology Additionally, glucocorticosteroids may reduce anti-tumor effects Breast cancer is the most common cause of cancer morbidity in of some chemotherapeutic agents [9]. women worldwide [1]. In 2016, it was estimated that approximately INTRODUCTION260,370 new cases were diagnosed in the United States [2]. First- biotechnologyCINV proceeds to expedite with modern revelations and line treatment for early breast cancer is curative surgery, but the uniqueBackground applications predicted to aid the economy throughout Peoplecancer have relapse applied rate isbiotechnology relatively high operations, when using such surgery as selectivelyalone [3, 4]. the 21st century [10-12]. breedingResearches animals indicated and fermentation, that the addition for thousandsof adjuvant of chemotherapy years [1,2]. Before the advent of 5-hydroxytryptamine-3 (5-HT3)– receptor Late 19th and early 20th century explorations revealed how Geneantagonists targeting and is aneurokinin-1–receptor particular technique thatantagonists, uses homologous CINV was to surgery provided clinical benefit for breast cancer patients [5]. recombination to shift an endogenous gene and can be used to microorganismsA widely used postoperativeaccomplish adjuvantcommercially chemotherapy advantageous protocol poorly controlled. Among patients undergoing chemotherapy, procedures and how they provoke disease contribute to the eliminate70% to 80%a gene, experienced omit exons, severe insert CINV.7 a gene, Risk or factors include for pointCINV includes combination therapy [6, 7]. While has therapeutic mutations [13]. Genetic engineering has applications in industrialefficacy, productionuse of this therapyof vaccines also andhas antibioticsconcomitant [3,4]. adverse Upgraded effects, include female gender, young age, and treatment with highly approaches for animal breeding have also emanated from these medicine,emetogenic research, chemotherapy.8 industry, and Chemotherapy agriculture and agents can beare used divided on including neutropenia, thrombocytopenia, nausea, vomiting, different types of plants, animals, and microorganisms [9,14]. venturesdiarrhea, [5]. asthenia Scientists and within neurotoxicity the San Francisco [6]. While Bay application Area took aof into 4 emetogenic risk levels: high (> 90%), moderate (30%– largethese leap drugs forward can effectively with the reduce invention symptoms, and developmentthese agents alsoof Genetic90%), lowengineering (10%–30%), has and staged minimal a collection (< 10%).1,9 of CINVdrugs canand be recombinant DNA techniques in the 1970s [6-9]. The area of hormoneseither acute, for delayed,medical oruse. anticipatory. One of itsAcute initial CINV applications occurs within in Correspondence to: Withanage SR, ITMO University, SCAMT Laboratory, Saint Petersburg, 191002, Russian Federation, E-mail: [email protected] to: Seyedeh Aghaghia Reza Tofighi BS, Isfahan University of Medical Sciences, Isfahan, Iran. Tel;989177420413 E-mail: aghaghia_ Citation:[email protected], Withanage SR, Daniil Received K (2020) date: JulyGenetically 10, 2020; Engineered Accepted date:Biomaterials. July 16, Adv2020; Genet Published Eng 9:161. date: doi:July 31,10.35248/2169-0111.2020.9.161 2020 Citation: Tofighi SAR, Reyhani M, et al. (2020) The effect of Auriculotherapy in the Control of Chemotherapy-Induced Nausea and Vomiting in ReceivedWomen date: with MayBreast 07, Cancer. 2020; Accepted J Can Sci date:Res 5:102. May 15, doi:10.35248/2576-1447.20.5.102 2020; Published date: May 25, 2020 Copyright:Copyright: © © 2020 2020 Withanage Tofighi SAR, SR, et et al. al. This This is is an an open-access open-access article article distributed distributed under under the the terms terms of of the the Creative Creative Commons Commons Attribution Attribution License, License, whichwhich permits permits unrestricted unrestricted use, use, distribution, distribution, and and reproduction reproduction in inany any medium, medium, provided provided the the original original author author and and source source are are credited. credited. J Can Sci Res, Vol.5 Iss.2 ISSN: 2576-1447 • Page 1 of 6 • Adv Genet Eng, Vol.9 Iss.161 1 Reyhani M Advancement in Genetic Engineering Review Article 24 hours of chemotherapy, usually beginning within 2 to 4 hours significantly better than the 2-drug combination of ondansetron and peaking in the first 4 to 6 hours.8 Delayed CINV occurs and dexamethasone during a 5-day study in patients undergoing Geneticallyfrom day 2 to 6 Engineeredof chemotherapy.8 BiomaterialsAnticipatory CINV occurs highly emetogenic chemotherapy.17,18 These results led the FDA before chemotherapy treatments in patients who have previously to approve adding aprepitant to antiemetic regimens for patients * SinithRashminexperienced significant Withanage CINV.8 ,Most Kladko