In August 1995, Cold Spring Harbor Laboratory Press will begin publication of a new, monthly, international, peer-reviewed journal, GENOME RESEARCH. The journal will focus on genome studies in all species, including genetic and physical mapping, DNA sequencing, gene discovery, informatics, statistical and mathematical methods and genome structure and function as well as technological innovations and applications. New data in these areas will be published as research papers, review articles, short re- ports, and summaries of physical mapping and large-scale sequencing projects. GENOME RESEARCH will incorporate PCR METHODS & APPLICATIONS, which for the past 4 years has published practical papers describing amplification techni- ques and their use. For copies of Instructions to Authors: FAX: 516-367-8532 (OR) Cold Spring Harbor Laboratory Online http://www.cshl.org/ Editors Chris Fields Svante Paabo Aravinda Chakmvarti National Center for Genome Resources University of Munich Case Western Reserve University Simon Foote Leena Peltonen Richard Gibbs Walter and Eliza Hall Institute of Medical National Public Health Institute, Helsinki Baylor College of Medicine Research David Portcous Eric Green Phil Green MRC Human Genetics Unit National Center for Human Genome University of Washington Western General Hospita~ Edinburgh Research, NIH Kenshi Hayashi Roger Reeves Richard Myers Kyushu University Johns Hopkins University School of Medicine Stanford University School of Medicine Philip Hieter Bruce Roe Editorial Board (partial listing) The Johns Hopkins University School of Medicine University of Oklahoma Rakesh Anand Clare Huxley Rodney Rothstein Zeneca Pharmaceuticals St. Mary's Hospital Medical School Columbia University College of P&S Stylianos Antonarakis Howard Jacob Gerald Rubin University of Geneva Massacusetts General Hospital University of California, Berkeley Charles Auffray Alec Jeffreys Lloyd Smith CNRS University of Leicester University of Wisconsin-Madison Philip Avner Mark Johnston Randall Smith lnstitut Pasteur Washington University School of Medicine Baylor College of Medicine Andrea Ballabio Mary-Claire King Marcelo Bento Soares Telethon Institute of Genetics and Medicine University of California School of Public Health Columbia University and the New York State Bruce Birren Ben Koop Psychiatric Institute CaliforniaInstitute of Technology University of Victoria William Studier Michael Boehnke Pui-Yan Kwok Brookhaven National Laboratory University of Michigan School of Public Health Washington University School of Medicine Grant Sutherland Mark Boguski UIf Landegren Women's and Children's Hospita~ Adelaide National Center for Biotechnology/NIH Uppsala Biomedical Center Barbara Trask Anne Bowcock Mark Lathrop University of Washington University of Texas Southwestern Medical Center The Wellcome Trust Centre for Human Genetics GJ.B. van Ommen David Burke Michael Lovett Leiden University University of Michigan Medical School University of Texas Southwestern Medical Center John Wasmuth Jeffrey Chamberlain Jen-i Mao University of California, lrvine University of Michigan Medical School Genome Therapeutics Corporation Robert B. Weiss Ellson Chen Douglas Marchuk University of Utah Perkin-Elmer Corporation Duke University Medical Center Jean Weissenbach David R. Cox Thomas Mart Genethon, CNRS Stanford University School of Medicine Cold Spring Harbor Laboratory Richard Wilson Richard Durbin W. Richard McCombie Washington University School of Medicine $anger Centre Cold Spring Harbor Laboratory James Womack Joseph Ecker Susan Naylor Texas A&M University Universityof Pennsylvania University of Texas Health Science Center Managing Editor Biodaie Laboratories U.~rsity of Washington CoM Spring Harbor Laboratory /" Subscribe Today! SUBSCRIPTION INFORMATION Cold Spring Harbor Volume 5, 1995, contains 5 monthly Laboratory Press issues (beginning August 1995) 10 Skyline Drive Investigators are invited to O Individual Price (U.S.) - $70 submit papers to: Plainview, N.Y. 11803-2500 Individual Price (R.O.W. airlift Judy Cuddihy, Managing Editor Phone: 1-800-843-4388 or delivery) - $115 Genome Research 516-349-1930 Institutional Price (U.S.) - $245 Cold Spring Harbor Laboratory One Bungtown Road FAX: 516-349-1946 Institutional Price (R.O.W. airlift Cold Spring Harbor, NY 11724 delivery) - $290 E-marl: [email protected] at World Wide Web Site http://www.cshl.org/ Reader Service No. 386 GENES DEVELOPMENT VOLUME 9 NUMBER 10 PAGES 1149-1288 May 15, 1995 EDITORIAL BOARD J. Adams (Melbourne, Australia) I. Kadonaga (La Jolla, USA) Editors J. Beckwith (Boston, USA) R. Lehmann (Cambridge, USA) T. Grodzicker (Cold Spring Harbor) A. Berns (Amsterdam, The Netherlands) M. Levine (San Diego, USA) N. Hastie (Edinburgh) E. 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Send to: Dr. Copyright 1995 by Cold Spring Harbor Laboratory Press GENES & DEVELOPMENT May 15, 1995 Contents Review Inhibitors of mammalian G~ cyclin-dependent kinases 1149 Charles J. Sherr and James M. Roberts Research papers Identification of a developmental timer regulating the stability of embryonic cyclin A and a 1164 new somatic A-type cyclin at gastrulation John A. Howe, Mike Howell, Tim Hunt, and John W. Newport Regulation of genomic imprinting by gametic and embryonic processes 1177 J. Richard Chaillet, Debra S. Bader, and Philip