LOW - LEVEL LASER THeraPY CLINICAL EVIDENCE CONTENT 1. Low-Level Laser Therapy in Rehabilitation 4 Additive effects of low-level laser therapy with exercise on subacromial syndrom: A randomised, double-blind, controlled trial 4 Efficacy of low-level laser therapy in the management of neck pain: A systematic review and meta-analysis of randomised placebo or active-treatment controlled trials 5 Evaluation of low-level therapy effectiveness on the pain and masticatory performance of patients with myofascial pain 6 A randomised, placebo controlled trial of low-level laser therapy for activated achilles tendinitis with microdialysis measurement of peritendinous prostaglandin E2 concentrations 7 Effect of low–level laser therapy on the expression of inflammatory mediators and on neutrophils and macrophages in acute joint inflammation 8 Effectiveness of physiotherapy and GaAIAs laser in the management of temporomandibular joint disorders 9 Evaluation of low-level laser therapy in TMD patients – A case report 10 A systematic review of low level laser therapy with location-specific doses for pain from chronic joint disorders 11 Role of low-level laser therapy in neurorehabilitation 12 2. Low-Level Laser Therapy in Dermatology 13 Low-level laser therapy in skin – Stimulating, Healing, Restoring 13 Low-level laser therapy – A conservative approach to the burn scar 14 Prophylactic low-level light therapy for the treatment of hypertrophic scars and keloids – A case series 15 Effects of low–level laser therapy on the progress of wound healing in humans: The contribution of in vitro and in vivo experimental studies 16 Effect of laser phototherapy on reccuring herpes labialis prevention – An in vivo study 17 Blue and red light combination led phototherapy for acne vulgaris in patients with skin phototype IV 18 Helium-neon laser irradiaton stimulates migration and proliferation in melanocytes and induces repigmentation in segmental – type vitiligo 20 The use of laser acupuncture for the treatment of neurogenic pruritus in a child – A case history 21 3. Low-Level Laser Therapy in Otorhinolaryngology 22 Effects of Low-level laser therapy on ovalbumin-induced mouse model of allergic rhinitis 22 Low-level laser therapy of sinusitis 23 Potential anti-inflammatory effect of Low-level laser therapy on the experimental reflux laryngitis: A preliminary study 24 Low–level laser therapy in patients with complaints of tinnitus – A clinical study 25 Low-level laser for treatment of tinnitus: A self-controlled clinical trial 26 4. Low-Level Laser Therapy in Dentistry 27 A clinical investigation of Low-level laser irradiation on hypersensitive dentine 27 The effect of Low-level laser therapy during orthodontic movement – A preliminary study 28 Comparison of the Low-level laser therapy effects on cultured human gingival fibroblasts proliferation using different irradiance and same fluence 29 5. Low-Level Laser Therapy - Other clinical indications 30 Efficiency of therapeutic ultrasound, Low-level laser and compression therapy for healing of venous leg ulcers 30 Low-level laser therapy of leg ulcer in sickle cell anemia 31 Laser acupuncture therapy for primary monosymptomatic nocturnal enuresis 32 Low reactive level laser therapy for mesenchymal stromal cells therapies – Review article 33 Effect of Low-level laser therapy on patient reported measures of oral mucositis and quality of life in head and neck cancer patients receiving chemoradiotherapy – A randomized controlled trial 34 4 5 1. LOW-level laSer THeraPY in reHABiliTATION TITLE: EFFICACY OF LOW-LEVEL LASER THERAPY IN THE MANAGEMENT OF NECK PAIN: A SYSTEMATIC REVIEW AND TITLE: ADDITIVE EFFECTS Of LOW-LEVEL LASER THERAPY META-ANALYSIS OF RANDOMISED PLACEBO OR ACTIVE- WITH EXERCISE ON SUBACROMIAL SYNDROME: A RANDOMISED, TREATMENT CONTROLLED TRIALS DOUBLE-BLIND, CONTROLLED TRIAL Authors: Roberta T. Chow, Mark I. Johnson, Rodrigo A. B Lopes-Martins, Jan M. Bjordal Authors: Seyyed Mohammad Jalil Abrisham, Mohammad Kermani-Alghoraishi, Rahil Ghahramani, Affiliations: University of Sydney, NW, Australia; Leeds Metropolitan University, Leeds, UK; Latife Jabbari, Hossein Jomeh, Maryam Zare University of Săo Paulo, Săo Paulo, Brazil; Bergen University College, Bergen, Norway; Affiliations: Shahid Sadoughi University of Medical Sciences, Yazd, Iran University of Bergen, Bergen, Norway Source: Clin Rheumatol. 2011 May; 30: 1341–1346 Source: Lancet 2009; 374: 1897-908 ABSTRACT: ABSTRACT: Introduction: Background: The subacromial syndrome is the most common source of shoulder pain. The mainstays Neck pain is a common and costly condition for which pharmacological management has of conservative treatment are non-steroidal anti-inflammatory drugs and exercise therapy. limited evidence of efficacy and side-effects. Low-level laser therapy (LLLT) is a relatively Recently, low-level laser therapy (LLLT) has been popularized in the treatment of various uncommon, non-invasive treatment for neck pain, in which non-thermal laser irradiation is musculoskeletal disorders. applied to sites of pain. We did a systematic review and metaanalysis of randomised controlled trials to assess the efficacy of LLLT in neck pain. Purpose: The aim of this study is to evaluate the additive effects of LLLT with exercise in comparison with Methods: exercise therapy alone in treatment of the subacromial syndrome. We searched computerised databases comparing efficacy of LLLT using any wavelength with placebo or with active control in acute or chronic neck pain. Effect size for the primary Materials and Methods: outcome, pain intensity, was defined as a pooled estimate of mean difference in change in mm We conducted a randomized clinical study of 80 patients who presented to clinic with on 100 mm visual analogue scale. subacromial syndrome (rotator cuff and biceps tendinitis). Patients were randomly allocated into two groups. In group I (n=40), patients were given laser treatment (pulsed infrared laser) Findings: and exercise therapy for ten sessions during a period of 2 weeks. In group II (n=40), placebo We identified 16 randomised controlled trials including a total of 820 patients. In acute laser and the same exercise therapy were given for the same period. Patients were evaluated neck pain, results of two trials showed a relative risk (RR) of 1,69 (95% CI 1,22–2,33) for pain for the pain with visual analogue scale (VAS) and shoulder range of motion (ROM) in an active improvement of LLLT versus placebo. Five trials of chronic neck pain reporting categorical data and passive movement of flexion, abduction and external rotation before and after treatment. In showed an RR for pain improvement of 4,05 (2,74–5,98) of LLLT. Patients in 11 trials reporting both groups, significant post-treatment improvements were achieved in all parameters (P=0.00). changes in visual analogue scale had pain intensity reduced by 19,86 mm (10,04–29,68). Seven In comparison between the two groups, a significant improvement was noted in all movements trials provided follow-up data for 1–22 weeks after completion of treatment, with short-term in group I (P=0.00). Also, there was a substantial difference between the groups in VAS scores pain relief persisting in the medium term with a reduction of 22,07 mm (17,42–26,72). Side- (P=0.00) which showed significant pain reduction in group I. effects from LLLT were mild and not different from those of placebo. Results and conclusion: Conclusion: Our study indicates that LLLT combined with exercise therapy is more effective than exercise We show that LLLT reduces pain immediately after treatment in acute neck pain and up to 22 therapy alone in relieving pain and in improving the shoulder joint ROM in patients with weeks after completion of treatment in patients with chronic neck pain. subacromial syndrome (rotator cuff and biceps tendinitis), but further studies with larger samples, longer term findings and possible comparisons with other conservative interventions are needed to establish the effectiveness of this protocol. 6 7 TITLE: EVALUATION OF LOW-LEVEL THERAPY EFFECTIVENESS TITLE: A RANDOMISED, PLACEBO CONTROLLED TRIAL OF ON THE PAIN AND MASTICATORY PERFORMANCE OF PATIENTS LOW-LEVEL LASER THERAPY FOR ACTIVATED ACHILLES TENDINITIS WITH MYOFASCIAL PAIN WITH MICRODIALYSIS MEASUREMENT OF PERITENDINOUS PROSTAGLANDIN E2 CONCENTRATIONS Authors: Mila Leite de Moraes Maia, Maria Amália Gonzaga Ribeiro, Luiz Guilherme Martins Maia, Juliana Stuginski-Barbosa, Yuri Martins Costa, André Luís Porporatti, Paulo César Rodrigues Authors: J. M. Bjordal, R. A. B. Lopes-Martins, V. V. Iversen Conti, Leonardo Rigoldi Bonjardim Affiliations: University of Bergen, Bergen, Norway Affiliations: Federal University of Sergipe, Sergipe, Brazil; Tiradentes Univesity, Tiradentes, Brazil; Source: Br. J. Sports Med. 2006; 40: 76-80 University of São Paulo, Bauru, Brazil Source: Lasers Med Sci. 2014; 29: 29-35 ABSTRACT: ABSTRACT: Introduction: Low-level laser therapy (LLLT) has gained increasing popularity in the management of tendinopathy Background: and arthritis. Results from in vitro and in vivo studies have suggested that inflammatory modulation is Study investigated the effect of low-level laser therapy (LLLT) on the masticatory performance one of several possible biological mechanisms of LLLT action. (MP), pressure pain threshold (PPT), and pain intensity in patients with myofascial pain. Objective: Methods: To investigate in situ if LLLT has an anti-inflammatory effect on activated tendinitis of the human Twenty-one subjects, with myofascial