Proactive Control: Neural Oscillatory Correlates of Conflict Anticipation and Response Slowing

Proactive Control: Neural Oscillatory Correlates of Conflict Anticipation and Response Slowing

This Accepted Manuscript has not been copyedited and formatted. The final version may differ from this version. A link to any extended data will be provided when the final version is posted online. Research Article: New Research | Cognition and Behavior Proactive Control: Neural Oscillatory Correlates of Conflict Anticipation and Response Slowing Neural oscillation in proactive control Andrew Changa, Jaime S. Ideb, Hsin-Hung Lia, Chien-Chung Chena,c and Chiang-Shan Ray Lib,d,e,f aDepartment of Psychology, National Taiwan University, Taipei, Taiwan bDepartment of Psychiatry, Yale University, New Haven, CT USA cCenter for Neurobiology and Cognitive Science, National Taiwan University, Taipei, Taiwan dDepartment of Neuroscience, Yale University, New Haven, CT USA eInterdepartmental Neuroscience Program, Yale University, New Haven, CT USA fBeijing Huilongguan Hospital, Beijing, China DOI: 10.1523/ENEURO.0061-17.2017 Received: 24 February 2017 Revised: 8 May 2017 Accepted: 8 May 2017 Published: 16 May 2017 Author Contributions: All authors designed research; AC, HHL, CCC and CSRL performed research; AC, JSI and CSRL contributed unpublished analytic tools and analyzed data; All authors wrote the paper. Funding: Ministry of Science and Technology, Taiwan (MOST) 501100004663 103-2410-H-002-076-MY3 Funding: National Science Foundation (NSF) 100000001 BCS1309260 Funding: HHS | National Institutes of Health (NIH) 100000002 DA023248 Funding: HHS | National Institutes of Health (NIH) 100000002 DA026990 Funding: HHS | National Institutes of Health (NIH) 100000002 AA021449 The authors declare no competing financial interests. This study was supported by Taiwan MOST (Taiwan) 103-2410-H-002-076-MY3 (CCC), NIH grants DA023248, DA026990 (C-SRL) and AA021449 (C-SRL), and NSF grant BCS1309260 (C-SRL). The funding agencies were otherwise not involved in data collection and analysis or in the decision in publishing the results. Correspondence should be addressed to either Chien-Chung Chen, Department of Psychology, No. 1, Sec. 4, Roosevelt Rd., Taipei, Taiwan 10617. E-mail: [email protected] or Chiang-Shan Ray Li, Department of Psychiatry, CMHC S112 34 Park Street New Haven, CT 06519. E-mail: [email protected] Cite as: eNeuro 2017; 10.1523/ENEURO.0061-17.2017 Alerts: Sign up at eneuro.org/alerts to receive customized email alerts when the fully formatted version of this article is published. Accepted manuscripts are peer-reviewed but have not been through the copyediting, formatting, or proofreading process. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International (http:// creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Copyright © 2017 the authors ϭ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ϭ Ϯ ϭ $EVWUDFW Ϯ 3URDFWLYHFRQWURODOORZVXVWRDQWLFLSDWHHQYLURQPHQWDOFKDQJHVDQGDGMXVWEHKDYLRXUDOVWUDWHJ\ ϯ ,QWKHODERUDWRU\LQYHVWLJDWRUVKDYHXVHGDQXPEHURIGLIIHUHQWEHKDYLRXUDOSDUDGLJPVLQFOXGLQJ ϰ WKHVWRSVLJQDOWDVN 667 WRH[DPLQHWKHQHXUDOSURFHVVHVRISURDFWLYHFRQWURO3UHYLRXVI05, ϱ VWXGLHVRIWKH667KDYHGHPRQVWUDWHGUHJLRQDOUHVSRQVHVWRFRQIOLFWDQWLFLSDWLRQ±WKHOLNHOLKRRG ϲ RIDVWRSVLJQDORU3 6WRS DVHVWLPDWHGE\D%D\HVLDQPRGHO±DQGUHDFWLRQWLPH 57 VORZLQJ ϳ DQGKRZWKHVHUHVSRQVHVDUHLQWHUUHODWHG+HUHLQDQHOHFWURSK\VLRORJLFDOVWXG\ZHLQYHVWLJDWHG ϴ WKHWLPHIUHTXHQF\GRPDLQVXEVWUDWHVRISURDFWLYHFRQWURO7KHUHVXOWVVKRZHGWKDWFRQIOLFW ϵ DQWLFLSDWLRQDVLQGH[HGE\3 VWRS ZDVSRVLWLYHO\FRUUHODWHGZLWKWKHSRZHULQORZWKHWDEDQG ϭϬ ±+] LQWKHIL[DWLRQ WULDORQVHW ORFNHGLQWHUYDODQG*R57ZDVQHJDWLYHO\FRUUHODWHGZLWK ϭϭ WKHSRZHULQGHOWDWKHWDEDQG ±+] LQWKHJRORFNHGLQWHUYDO6WLPXOXVSUHGLFWLRQHUURUZDV ϭϮ SRVLWLYHO\FRUUHODWHGZLWKWKHSRZHULQWKHORZEHWDEDQG ±+] LQWKHVWRSORFNHGLQWHUYDO ϭϯ )XUWKHUWKHSRZHURIWKH3 VWRS DQG*R57FOXVWHUVZDVQHJDWLYHO\FRUUHODWHGSURYLGLQJD ϭϰ PHFKDQLVPUHODWLQJFRQIOLFWDQWLFLSDWLRQWR57VORZLQJLQWKH6676RXUFHUHFRQVWUXFWLRQZLWK ϭϱ EHDPIRUPHUORFDOL]HGWKHVHWLPHIUHTXHQF\DFWLYLWLHVFORVHWREUDLQUHJLRQVDVUHYHDOHGE\I05, ϭϲ LQHDUOLHUZRUN7KHVHDUHWKHILUVWUHVXOWVWRVKRZRVFLOODWRU\HOHFWURSK\VLRORJLFDOVXEVWUDWHVLQ ϭϳ VXSSRUWRIWULDOE\WULDOEHKDYLRXUDODGMXVWPHQWIRUSURDFWLYHFRQWURO ϭϴ .H\ZRUGV1HXUDORVFLOODWLRQ((*3URDFWLYHFRQWURO6WRSVLJQDOWDVN%D\HVLDQPRGHO ϭϵ Ϯ ϯ ϮϬ 6LJQLILFDQFHVWDWHPHQW Ϯϭ 3URDFWLYHFRQWUROLVFHQWUDOWRDGDSWLYHEHKDYLRU0DQ\I05,VWXGLHVKDYHGLVVHFWHGWKHQHXUDO ϮϮ EDVLVRIFRQIOLFWSURFHVVLQJDQGEHKDYLRUDODGMXVWPHQWEXWHYLGHQFHIURPHOHFWURSK\VLRORJ\LV Ϯϯ IUDJPHQWDU\+HUHE\FRPELQLQJ((*DQGDVWRSVLJQDOWDVNZHGHPRQVWUDWHGGLVWLQFW Ϯϰ IUHTXHQF\GRPDLQVXEVWUDWHVRIFRQIOLFWDQWLFLSDWLRQ57VORZLQJDQGVWLPXOXVSUHGLFWLRQHUURU Ϯϱ ,QSDUWLFXODUQHXUDODFWLYLWLHVRIFRQIOLFWDQWLFLSDWLRQSUHFHGHG57VORZLQJDQGWKHSRZHURI Ϯϲ WKHVHDFWLYLWLHVDUHFRUUHODWHGLQVXSSRUWRISURDFWLYHFRQWURORIEHKDYLRU)XUWKHUEHDPIRUPHU Ϯϳ DQDO\VLVORFDOL]HGWKHVRXUFHVRIWKHVHDFWLYLWLHVDVUHYHDOHGE\I05,7KHVHQHZILQGLQJV Ϯϴ FRPSOHPHQWWKHOLWHUDWXUHE\VSHFLI\LQJWKHHOHFWURSK\VLRORJLFDOFRUUHODWHVRIWULDOE\WULDO Ϯϵ UHVSRQVHFRQWUROZLWKLQDVLQJOHSDUDGLJP ϯ ϰ ϯϬ ,QWURGXFWLRQ ϯϭ 7KHDELOLW\WRPDNHSODQVDQGSURDFWLYHO\DGMXVWRXUEHKDYLRULVFULWLFDOWRVXUYLYDO ϯϮ 3URDFWLYHFRQWUROKDVEHHQVWXGLHGZLWKPDQ\GLIIHUHQWEHKDYLRUDOSDUDGLJPVZKHUHSDUWLFLSDQWV ϯϯ DUHFXHGWRXSFRPLQJHYHQWV %UDVVDQG+DJJDUG&KLND]RHHWDO+RUJDHWDO ϯϰ -DKIDULHWDO.KQHWDO/HXQLVVHQHWDO9LQNHWDO ,QWKHVWRS ϯϱ VLJQDOWDVN 667 IRULQVWDQFHIUHTXHQWPRWRUUHVSRQVHVDUHWREHLQWHUUXSWHGRFFDVLRQDOO\E\D ϯϲ VWRSVLJQDODQGLQFUHDVHGVWRSVLJQDOSUREDELOLW\EROVWHUVSURDFWLYHFRQWURODVVKRZQLQVORZHU ϯϳ UHVSRQVHWLPHDQGGHOD\HGPRWRUFRUWLFDODFWLYLW\ -DKIDULHWDO 3DUWLFLSDQWVW\SLFDOO\ ϯϴ GHPRQVWUDWHVORZHUUHDFWLRQWLPH 57 IROORZLQJDVWRSVLJQDORUSRVWVLJQDOVORZLQJ 366 LQ ϯϵ WKH667$VLQYHVWLJDWHGH[WHQVLYHO\LQEHKDYLRUDOVWXGLHV366GRHVQRWUHIOHFWWKHVXUSULVH ϰϬ HIIHFWVRIVWRSVLJQDOEXWUDWKHUDJOREDOFRQWH[WXDOPRGXODWLRQRIVLJQDOH[SHFWDQF\RQPRWRU ϰϭ UHVSRQVH %LVVHWWDQG/RJDQ0RUHLQ=DPLUHWDO ,QGLIIXVLRQPRGHOVRI667GDWD ϰϮ UHVSRQVHWKUHVKROGLQFUHDVHGZKHQVWRSVLJQDOVZHUHH[SHFWHGWRRFFXUDQGSDUWLFLSDQWVPDGH ϰϯ UHVSRQVHVWUDWHJ\DGMXVWPHQWVRQDWULDOE\WULDOEDVLVVXJJHVWLQJSURDFWLYHDGMXVWPHQWWR ϰϰ FKDQJLQJHQYLURQPHQWV 9HUEUXJJHQDQG/RJDQE 2QWKHRWKHUKDQGWKHQHXUDO ϰϱ PHFKDQLVPVXQGHUO\LQJWULDOE\WULDOEHKDYLRUDODGMXVWPHQWKDYHRQO\EHHQH[DPLQHGUHFHQWO\ ϰϲ XQGHUDIRUPDOFRPSXWDWLRQDOIUDPHZRUN ϰϳ ,QDSUHYLRXVI05,VWXG\RIWKH667DXWKRUVDSSOLHGDG\QDPLF%D\HVLDQPRGHOWR ϰϴ HVWLPDWHWULDOE\WULDOSUREDELOLW\RIWKHVWRSVLJQDO±3 6WRS ±DQGVKRZHGWKDWKLJKHU3 6WRS LV ϰϵ DVVRFLDWHGZLWKSURORQJHGJRWULDO57LQGLFDWLQJSURDFWLYHFRQWURORIPRWRUUHVSRQVH +XHWDO ϱϬ D 7KHJLVWRIWKHVWXG\ZDVWRLGHQWLI\DQGGLVWLQJXLVKUHJLRQDOEUDLQDFWLYDWLRQVVSHFLILFWR ϱϭ VLJQDODQWLFLSDWLRQDQGUHVSRQVHVORZLQJDVDUHVXOWRIWKHDQWLFLSDWLRQ,QPRGHOLQJI05,VLJQDOV ϱϮ DWWULDODQGWDUJHWRQVHWVWKH\VKRZHGWKDWWKHDQWHULRUSUHVXSSOHPHQWDU\PRWRUDUHD SUH60$ ϰ ϱ ϱϯ UHVSRQGVWRLQFUHDVHG3 6WRS LQFRUUHODWLRQZLWKDFWLYDWLRQVRIWKHSRVWHULRUSUH60$DQG ϱϰ ELODWHUDODQWHULRULQVXODGXULQJSURORQJHG577KHVHILQGLQJVDVVRFLDWHFRQIOLFWDQWLFLSDWLRQZLWK ϱϱ LWVPRWRUFRQVHTXHQFH ϱϲ 0DQ\VWXGLHVLGHQWLILHGWLPHGRPDLQHYHQWUHODWHGSRWHQWLDOV (53V LQDVVRFLDWLRQZLWK ϱϳ SURDFWLYHFRQWUROLQFOXGLQJSURFHVVHVUHODWHGWRVZLWFKSUHSDUDWLRQRUDQWLFLSDWRU\DWWHQWLRQ ϱϴ $QJHOLQLHWDO'L5XVVRHWDO/DQJIRUGHWDOVHHDOVR.

View Full Text

Details

  • File Type
    pdf
  • Upload Time
    -
  • Content Languages
    English
  • Upload User
    Anonymous/Not logged-in
  • File Pages
    45 Page
  • File Size
    -

Download

Channel Download Status
Express Download Enable

Copyright

We respect the copyrights and intellectual property rights of all users. All uploaded documents are either original works of the uploader or authorized works of the rightful owners.

  • Not to be reproduced or distributed without explicit permission.
  • Not used for commercial purposes outside of approved use cases.
  • Not used to infringe on the rights of the original creators.
  • If you believe any content infringes your copyright, please contact us immediately.

Support

For help with questions, suggestions, or problems, please contact us