CancerResearch AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH December 15, 1998 Volume 58 •Number 24 PP. 5633-5890 ISSN0008-5472 •CNREA 8 AMERICAN ASSOCIATION FOR CANCER RESEARCH 90TH ANNUAL MEETING April 10-14,1999 Pennsylvania Convention Center, Philadelphia, PA SPECIAL EVENTS (Topics with Confirmed Speakers/Organizers in Parentheses) EDUCATIONAL SESSIONS AND METHODS WORK "MEET-THE-EXPERT" SUNRISE SESSIONS SHOPS (SATURDAY AFTERNOON, APRIL 10, 1999) DrugResistance(Susan P. C. Cole) To Be Announced Cancer Screening(Barnett S. Kramer) Molecular Signaling of CML (Jean Y. J. Wang) OFFICIAL OPENING EVENT (SUNDAY MORNING, Apoptosis and Chemotherapy (John A. Hickman) APRIL 11, 1999) Caspases (Nancy A. Thornberry) Presidential Address (Webster K. Cavenee) Molecular Cytogenetics (Joe W. Gray) Plenary Session: New Frontiers in Cancer Research p53 GeneTherapy-mediatedRadio/Chemosensitization(Esther H. Chang) Genetics (Robert A. Weinberg) The Genetics of Multiple Endocrine Neoplasia Type 2 (MEN 2) (Bruce A. J. Immunology and Vaccines (Lloyd J. Old) Ponder) Therapeutics and Translational Research (Judah Folkman) Differentiation Therapy (Samuel Waxman) Hormonal Intervention and Prevention (C. Kent Osborne) AIDS-related Malignancies (Ellen G. Feigal) AACR-Pezcoller International Cancer Research Award Lecture Tumor Vaccine Therapy (Michael T. Lotze) Special Lecture (James D. Watson) Integration of Biological Agents into Radiotherapy (William H. McBride) Molecular Detection of Minimal Residual Disease (Theodore F. Zipf) SYMPOSIA Microsatellite Instability (David Sidransky) Animal Models for Human Cancer: Recent Developments, New Chemoprevention Trials: Science vs. Art vs. Fantasy (David S. Alberts) Challenges (Tyler Jacks) Genetic Imprinting (Andrew P. Feinberg) Advances in Chemoprevention (Raymond N. DuBois) Cancer Metastasis: Cellular and Clinical Studies (David Tarin) Infectious Agents and Cancer (Nancy E. Mueller) Embryonal Stem-cell-based Technology (Randall Johnson) Ubiquitin and Protein Degradation (Alexander J. Varshavsky) Replicative Senescence (Judith Campisi) Genomics, Genetics, and New Approaches to Cancer (Richard D. Drug Design and Development (Randall K. Johnson) Klausner) In l'ivo Imaging of Gene Expression in Solid Tumors (Ralph Weissleder) Transcriptional Regulation and Cancer (Lorraine J. Gudas) The RB Family and CDKs in the Cell Cycle in Cancer (Antonio Giordano) Drug Discovery: From Basic Science to the Clinic (Daniel D. Von Hoff) Prospects for Biological Agents (Peter J. Houghton) Cancer Vaccines (Ronald Levy) Disorders in Cell Circuitry in Cancer (I. Bernard Weinstein) DNA Repair (Richard D. Kolodner) bcl2: Its Family and Modification (Timothy J. McDonnell) Telomeres, Centromeres, and Chromosomal Instability (Carol W. Topic to be Announced (Franklyn Prendergast) Greider) Chemoprevention in Respiratory Cancer (Lee W. Wattenberg) Basic and Clinical Approaches to Ovarian Cancer (Robert C. Bast, Jr.) TGF-ßand Colon Cancer (Sanford Markowitz) Gene Environment Interactions in Cancer Etiology (Margaret R. Spitz Inherited Susceptibility to Breast and Ovarian Cancers (Funmi I. Olopade) and Kenneth Olden) VEGF (Harold F. Dvorak) Apoptosis (Craig B. Thompson) Origins of Melanoma (Margaret A. Tucker) Molecular Targeted Therapy (John Mendelsohn) Biology of Premalignant Lesions (Walter N. Hittelman) Basic and Clinical Approaches to Lung Cancer (David Paul Carbone) Diet and Cancer: Process and Paradox (John D. Potter) Genetic Determinants of Prostate Cancer (William B. Isaacs) DNA Repair: Breaking Cycle-specific Constraints in Combination Therapy Genetic Instability, DNA Damage, and Checkpoint Regulation (Geoffrey (William K. Plunkett) Wahl) Invasion. Metastasis, and Angiogenesis (Isaiah J. Fidler) Antisense Therapies (Stanley T. Crooke) Drug Resistance and Cell Cycle Abnormalities (Joseph R. Bertino) Topic to be Announced (Nagahiro Saijo) Hormonally Related Tumors - Basic and Clinical Aspects (Bert W. Small Molecule Inhibitors of Protein Kinases That Block Tumor O'Malley and Marc E. Lippman) Angiogenesis for the Treatment of Cancer and Metastasis (Jerry Late Breaking Science (Waun Ki Hong and Webster K. Cavenee) McMahon) Topoisomerases in Carcinogenesis and Cancer Treatment (Leroy Fong Integration of Biological Agents into Chemotherapy (Herbert M. Pinedo) Liu) New Therapeutic Agents (Michaele C. Christian) Replication and the Cell Cycle (Jacqueline A. Lees) Function and Target Genes of myc in Neoplasia and Apoptosis (Chi Van Future Directions in Research on Tobacco and Cancer (Virginia L. Dang) Isolation of Genes Regulated by p53 or ß-cateninand Their Roles in Human Ernster) Advances in Stem Cell Gene Therapy (Cynthia E. Dunbar) Carcinogenesis(Vusuke Nakamura) BehavioralOncology(Barbara K. Rimer) FORUMS \liliN.!(Guillermina Lozano) Tamoxifen: Risks and Benefits Molecular Processes in DNA Repair After Irradiation (Gloria C. Li) Ethical and Legal Issues in Genetic Testing Natural Agents and Chemoprevention (Hirota Fujiki) The Genetics of Wilms Tumor (Michael R. DeBaun) Prevention and Treatment of Breast Cancer (Martin D. Abeloff) PROGRAM COMMITTEE Waun Ki Hong, Chairperson Carol W. Greider, Co-Chairperson Joseph F Fraumeni, Jr, Co-Chairperson Leroy F Liu, Co-Chairperson l-'urther Information AACR Office •Public Ledger Building, Suite 826 EDUCATION COMMITTEE • EXHIBITS COMMITTEE 150 S Independence Mall West • Philadelphia, PA 19106-3483 JetTrey M Trent, Chairperson David S Alberts. Chairperson LOCAL ARRANGEMENTS COMMITTEE Telephone: 215-440-9300« FAX 215-440-9313 Robert F Ozols, Chairperson E-mail: meetings:i/>aacr.org •Website: http://www.aacr.org msäa ResearchOpportunities At Amgen, you'll discover a research environment that emphasizes collaboration, intellectual honest)', scientific integrity, and a supportive ResearchAssociate (Job Code: 0000000138) culture. This unique approach has helped us grow into a global biotechnology leader in just 18 years. We are seeking research associates You will work with a select group of scientists who are discovering novel with a background in cancer-related research to work in our Cancer genes and examining signal transduction pathways that are altered during Biology program at Amgen. tumor genesis. We are seeking highly motivated individuals who are not only able to work efficiently in a team-oriented environment, but also ResearchScientist capable of designing experiments and thinking independently. You must (Job Code: 0000000137) possess technical experience in one or more ot the following areas: molecular biology, protein biochemistry, genomics, mammalian cell culture You will work in an exciting, fast-paced, state-of-the-art environment to and protein purification. A research background in apoptosís, angiogenesis, discover novel genes and pathways that regulate specific aspects of tumor cell cycle, ¡nvivo tumor models and tumor biology is preferred. A genesis. Positions are available for scientists with research experience in minimum of a Bachelor's degree in Science is required, a Master's degree or areas related to apoptosís, angiogenesis, cell adhesion, tumor biology and research experience in an academic or industrial setting is highly desirable. development of in vitro and in vivo assays for high-throughput screens. The cancer biology group collaborates with multiple groups within Amgen At Amgen, your accomplishments are rewarded. We orfer a highly including: protein chemistry, small molecule chemistry, high-throughput competitive compensation and benefits package that includes a retirement and savings plan, an on-site fitness center and three weeks' vacation. For screening, microarray and microprocessing, functional genomics and proteomics. The wide range ot resources available at Amgen enables immediate consideration, please mail your resume on plain white paper scientists to rapidly discover, characterize and validate potential therapeutic (indicating appropriate job code, using standard type and fonts, no bullets, targets. You must posses a Ph.D. in a molecular, biochemistry or cell italics, underlining or holding), to: Amgen, Staffing, P.O. Box 2569, Thousand Oaks, CA 91319-2569, or email your ASCII text resume to: biology program, with a minimum 3 years of postdoctoral experience in cancer-related research. A strong background in cancer research, a proven [email protected]. Please consult our Web Site at: www.amgen.com for publication track record, a drive to succeed and an ability to work in a information on other career opportunities available at Amgen. Principals team-oriented environment are key to your success. only, please. We recognize that diverse perspectives are a key in the process of discovery. EOE/AA Employer M/F/D/V. ¿MGEN Directorof Research ArkansasCancerResearchCenter Universityof Arkansasfor MedicalSciences The Arkansas Cancer Research Center (ACRC) at the University of Arkansas for Medical Sciences (UAMS) seeks nominations and applications for a Director of Research. Applicants must have an MD, PhD, or equivalent degree, and major administrative experience. He/she should have an active, funded program in basic and/or clinical cancer research. The candidate's scope, knowledge, and interest in cancer research should be sufficiently broad so that he/she can effectively interact with and facilitate the integration of the various research programs at the center. The Director of Research will oversee the overall development, coordination, and implementation of basic and clinical research at the ACRC. Specifically, the Director