MAIMOTOMONTANT US009918947B2 DIDIU TO HIM ON MINI (12 ) United States Patent ( 10 ) Patent No. : US 9 ,918 , 947 B2 Carberry ( 45) Date of Patent : Mar. 20 , 2018 ( 54 ) COMPOSITION OF OLIVETOL AND Roger G . Pertwee. Cannabinoid pharmacology : the first 66 years . METHOD OF USE TO REDUCE OR INHIBIT British Journal of Pharmacology ( 2006 ) 147, S163 - S171. * THE EFFECTS OF C . E . Turner, M . A , Elsohly , E . G . Boeren , Constituents of Cannabis sativa L . XVII . A Review of the Natural Constituents , J . Nat. Prod . TETRAHYDROCANNABINOL IN THE 43 : 2 ( 1980 ) , pp . 169 - 234 . ( Year : 1980 ) . * HUMAN BODY I . Z . Stojanovic , et al . “ Volatile constituents of selected Parmeliaceae lichens” , J . Serb . Chem . Soc . 76 ( 7 ) 987 - 994 ( 2011 ) . ( Year: 2011 ) . * (71 ) Applicant : Undoo , LLC , Mesa , AZ ( US ) “ Olivetol, " Material Safety Data Sheet No. SC - 236251 [online ] , Oct . 5 , 2009 , ChemWatch Pty . Ltd . , Australia . (72 ) Inventor : James J. Carberry , Mesa , AZ (US ) “ Resorcinol , 5 -pentyl -, ” Chemical Toxicity Database , 2006 - 2017 , DrugFuture, available at http : // www .drugfuture . com / toxic / q124 ( 73 ) Assignee : Undoo , LLC ,Mesa , AZ (US ) 9442 .html . Ethan B . Russo , “ Taming THC : Potential Cannabis Synergy and ( * ) Notice : Subject to any disclaimer, the term of this Phytocannabinoid - terpenoid Entourage Effects ,” British Journal of Pharmacology , Aug . 2011, pp . 1344 - 1364, vol. 163 , issue 7 , patent is extended or adjusted under 35 Blackwell Publishing Ltd . (John Wiley & Sons ) , London , UK . U . S . C . 154 ( b ) by 0 days . Futoshi Taura , Shinji Tanaka , Chiho Taguchi, Tomohide Fukamizu , Hiroyuki Tanaka , Yukihiro Shoyama, Satoshi Morimoto, “ Charac (21 ) Appl . No . : 15 / 360 , 389 terization of olivetol synthase , a polyketide synthase putatively involved in cannabinoid biosynthetic pathway ,” FEBS Letters , (22 ) Filed : Nov. 23 , 2016 2009 , pp . 2061- 2066 , Federation of European Biochemical Societ ies , Elsevier B . V . (65 ) Prior Publication Data Futoshi Taura , Shinji Tanaka , Chiho Taguchi, Tomohide Fukamizu , US 2017 /0143643 A1 May 25, 2017 Hiroyuki Tanaka , Yukihiro Shoyama, Satoshi Morimoto , “ Charac terization of olivetol synthase , a polyketide synthase putatively involved in cannabinoid biosynthetic pathway ,” FEBS Letters , Related U . S . Application Data 2009 , pp . 2061 - 2066 , European PMC . Helno Lepp , “ Chemistry , " Information about Australian Lichens, (60 ) Provisional application No . 62/ 258 , 979, filed on Nov. www . anbg . gov .au / lichen /chemistry - 1 .html , Sep . 18 , 2012 , Austra 23 , 2015 . lian National Botanic Gardens & Australian Nat ' l Herbarium , Canbarra , AUS (51 ) Int. CI. Jurg Gertsch , Roger G . Pertwee , and Vincenzo Di Marzo , A61K 9 / 48 ( 2006 .01 ) “ Phytocannabinoids Beyond the Cannabis Plant - DoThey Exist ?” A61K 9 /00 ( 2006 .01 ) British Journal of Pharmacology, 2010 , pp . 523 -529 , vol . 160 , A61K 9 / 127 ( 2006 . 01 ) Blackwell Publishing Ltd . ( John Wiley & Sons ), London , UK . A61K 31/ 05 ( 2006 . 01 ) Lumir Ondrej Hanus , " Pharmacological and TherapeuticSecrets of Plant and Brain ( Endo )Cannabinoids , ” Wiley Interscience (www . (52 ) U . S . CI. interscience .wiley .com ), Sep . 5 , 2008 (also found in Medicinal CPC .. .. .. .. A61K 31/ 05 ( 2013 .01 ) ; A61K 9 / 0053 Research Reviews , 2009 , pp . 213 - 271 , vol. 29 , No. 2 , Wiley ( 2013 .01 ) ; A61K 9 / 127 ( 2013 .01 ) ; A61K Periodicals , Inc .) . 9 / 4825 ( 2013 . 01 ) ; A61K 9 /4858 ( 2013 . 01 ) ; M . G . Cascio , T . Bisogno , E . Palazzo , A . Thomas, M . Van Der Stelt , A . Brizzi, V . De Novellis , I. Marabese , R . Ross , T . Van De Doelen , A61K 9 /4875 ( 2013 . 01 ) V . Brizzi , R . Pertwee , S . Maione, and V . DiMarzo , “ In Vitro and In (58 ) Field of Classification Search Vivo Pharmacology of Synthetic Olivetol- or Resorcinol- Derived None Cannabinoid Receptor Ligands, British Journal of pharmacology , See application file for complete search history. Sep . 4 , 2006 [ online ] ( also found in British Journal of Pharmacology [ print] , Oct. 2006 , pp . 431 -440 , vol. 149 , No . 4 , Nature Publishing References Cited Group ) . ( 56 ) Murielle Rinaldi- Carmona , Francis Barth , Michel Heaulme, David Shire , Bernard Calandra , Christian Congy, Serge Martinez , Jeanne U . S . PATENT DOCUMENTS Maruani, Gervais Neliat , Daniel Caput, Pascual Ferrara , Philippe 3 ,734 , 930 A * 5 / 1973 Razdan .. .. C07D 311/ 80 Soubrie, Jean Claude Breliere , Gerard Le Fur, “ SR141716A , a 549 /390 Potent and Selective Antagonist of the Brain Cannabinoid Recep 8 ,231 , 896 B2 7 / 2012 Tanner tor, ” FEBS Letters , 1994 , pp . 240 - 244 , vol. 350 , Federation of 8 ,808 ,734 B2 * 8 /2014 Winnicki . .. .. .. A61K 9 / 127 European Biochemical Societies . 424 /450 O ' Shaughnessy ' s News Service , “ At the 2012 ICRS Conference : 2007 /0116812 Al 5 / 2007 Msika Mechoulam ' s To -Do List for Researchers : CBD , the CB2 Receptor, 2010 / 0021573 AL 1 / 2010 Gonzales and ‘ F - Triple - A ' s , ' ” BeyondTHC . com , pp . 7 - 8 , Winter /Spring 2012/ 0263785 Al * 10 / 2012 Rossi A61K 9 / 4858 2013 , O 'Shaughnessy ' s . 424 / 451 (Continued ) FOREIGN PATENT DOCUMENTS Primary Examiner — Isaac Shomer Assistant Examiner — Michael P Cohen DE 102012105063 A1 12 /2013 (74 ) Attorney, Agent , or Firm — Matthew C . Lapple ; EP 1101491 A2 5 / 2001 Franklin D . Ubell ; Lapple Ubell IP Law , LLP WO 9505156 A1 2 / 1995 WO 2006017892 A1 2 / 2006 (57 ) ABSTRACT WO 2008139263 A2 11/ 2008 Embodiments of the present invention relate to the use of a therapeutically - effective amount of Olivetol to reduce , OTHER PUBLICATIONS eliminate , inhibit or alleviate the psychoactive effects of THC in users of Cannabis . Further embodiments of the Evelyn A . Formukong , A . Tudor Evans , Fred J . Evans . Inhibition of present invention relate to a softgel, tablet or capsule of the cataleptic effect of tetrahydrocannabinol by other constituents of Olivetol in combination with an edible oil. Cannabis sativa L . J . Pharm . Pharmacol. 1988 .40 : 132 - 134. * 19 Claims, No Drawings US 9 ,918 , 947 B2 Page 2 ( 56 ) References Cited Pharmacy and Pharmacology, 1988, vol. 40 , No . 2 , pp . 132 - 134 . See abstract . PCT International Search Report , dated Feb . 16 , 2017 , for Interna OTHER PUBLICATIONS tional Application No. PCT/ US2016 / 063645 ( International Filing Date Nov . 23 , 2016 ) . Satoshi Yamaori , Yasuka Okamoto , Ikuo Yamamoto , and Kazuhito PCT Written Opinion of the International Searching Authority , Watanabe, “ Cannabidiol, a Major Phytocannabinoid , as a Potent dated Feb . 16 , 2017 , for International Application No . PCT/ Atypical Inhibitor for CYP2D6 ,” Drug Metabolism and Disposi US2016 / 063645 ( International Filing Date Nov . 23 , 2016 ) . tion , Aug . 5 , 2011, p . 2049 , vol. 39 , No. 11, Am . Soc ' y for Product Information Sheet for Organic Hemp Seed Oil Capsules Pharmacology & Experimental Therapeutics : USA . from IAMSHAMA .com ( downloaded Oct. 11 , 2017 from https : // Zdenek Fisar, “ Phytocannabinoids and Endocannabinoids, ” Current web . archive. org /web /20120509082132 /https : / /www . iamshaman . Drug Abuse Reviews, 2009 , pp . 51 - 75 , vol. 2 , No . 1 , Bentham com /hemp seed - oil- capsules .htm ; via the Wayback Machine , dated Science Publishers Ltd . May 9 , 2012 Beg, S . et al . Systemic review of herbals as potential anti- inflam Igor Z . Stojanovic , Niko S . Radulovic , Tatjana LJ . Mitrovic , Slavisa matory agents : Recent advances, current clinical status and future M . Stamenkovic and Gordana S . Stojanovic . Volatile constituents of perspectives. Pharmacognosy Reviews . 2011 , vol . 5 , No. 10 , pp . selected Parmeliaceae lichens. J. Serb . Chem . Soc . 76 ( 7 ) 987 -994 120 - 137 . See the whole document. ( 2011) . Formukong , E . A . , et al. , Analgesic and Antiinflammatory Activity Marisa M . Wall. Functional lipid characteristics , oxidative stability , of Constituents of Cannabis sativa L . Inflammation , 1988, vol . 12 , and antioxidant activity of macadamia nut (Macadamia integrifolia ) No . 4 , pp . 361- 371 . See the whole document . cultivars . Food chemistry 121 ( 2010 ) 1103 - 1108 . Formukong, E . A . , Inhibition of the cataleptic effect of tetrahydro cannabinol by other constituents of Cannabis sativa L . Journal of * cited by examiner US 9 , 918 , 947 B2 COMPOSITION OF OLIVETOL AND cell signaling . In neurons , endocannabinoids bind to the METHOD OF USE TO REDUCE OR INHIBIT CB1 receptors at the pre -synaptic junction and , among other THE EFFECTS OF effects , impact the release of gamma - amino butyric acid TETRAHYDROCANNABINOL IN THE ( “GABA ” ) . However , when THC is present in the human HUMAN BODY 5 bloodstream , it binds to these cannabinoid receptors and causes many different psychotropic effects . Consumption of Cannabis by a human generally results in a wide variety of CROSS REFERENCE TO RELATED psychotropic effects , which is often referred to as a “ high .” APPLICATIONS The cannabis high varies depending on many factors, 110 including the strain of Cannabis , the amount consumed , the The subject application claims priority to U . S . Provisional method of consumption , the biochemistry of the individual Patent Application Ser. No . 62/ 258 , 979, filed on Nov . 23 , consuming it and the individual' s level of experience in 2015 , which application is incorporated herein in its entirety consuming cannabis . That said , a cannabis high can include by this reference thereto . euphoria , anxiety , a general