Bulletin The Canadian Society of Biochemistry and Molecular & Cellular Biology/ La Société canadienne de biochimie et de biologie moléculaire et cellulaire 2001 www.csbmcb.ca ISSN 1197-6578/2001 COVER PHOTO: A schematic diagram of the Sec dependent protein translocation system [from The 2001 Merck Frosst Prize Award Address Mark Paetzel and Natalie C. J. Strynadka] Contents CSBMCB Board for 2001-2002 ....................................................................................... 4 CSBMCB President’s Report ............................................................................................ 5 Incoming Members of CSBMCB Executive Board 2001-2002 ......................................... 6 IUBMB Toronto Congress Update ................................................................................. 13 Minutes of the 44th CSBMCB Annual General Meeting ................................................ 14 11th Winternational Symposium .................................................................................. 21 44th Annual Meeting of the CSBMCB .......................................................................... 22 Society Awards 2000-2001 ........................................................................................... 27 Workshop On: Myelin Structure And Its Role In Autoimmunity ..................................... 31 Report on the AUUBC................................................................................................... 34 In Memoriam Peter Dolphin ........................................................................................................... 35 Kenneth Percy Strickland .......................................................................................... 37 The 2000 Jeanne Manery Fisher Memorial Lecture Insulin-regulated Glut4 Traffic In Muscle Cells: .......................................................... 39 The 2001 Jeanne Manery Fisher Memorial Lecture Nucleoside transporter proteins ................................................................................ 52 The 2001 Merck Frosst Prize Award Address Signal peptide cleavage in the E. coli membrane ....................................................... 60 Review Article The Implantation Serine Proteinases: Potential Therapeutic Footholds in Female Fertility ................................................................................................... 66 Reminiscences From Montreal (1954-1956) ................................................................. 72 News from Biochemistry Centres University of British Columbia ................................................................................... 74 University Of Calgary ................................................................................................ 76 Dalhousie University ................................................................................................. 79 University of Guelph ................................................................................................. 79 University of Lethbridge ............................................................................................ 81 University of Manitoba .............................................................................................. 81 McMaster University ................................................................................................. 82 McGill University ....................................................................................................... 83 University of Alberta .................................................................................................. 84 University of Toronto ................................................................................................ 84 University of Saskatchewan ....................................................................................... 87 CSBMCB Board for 2001-2002 President Councillor Dr. Leon W. Browder Tel: (403) 220-6787 Dr. Claude Lazure Tel: (514) 987-5593 Department of Biochemistry FAX: (402)270-0737 Neuropeptides Structure & FAX: (514) 987-5542 & Molecular Biology E-Mail: [email protected] Metabolism Laboratory, E-Mail: [email protected] University of Calgary, Clinical Research Institute of 3330 University Drive, NW. Montreal, Calgary, Alberta, T2N 4N1 110 Pine Avenue West, Montreal, Quebec, H3W 1R7. Past-President Dr. Frances Sharom Tel: (519) 824-4120 Ext: 2247(office) Councillor Dept. of Chemistry and Ext: 6712 (Lab) Dr. David Litchfield Tel: (519) 661-4186 Biochemistry, FAX: (519) 766-1499 Department of Biochemistry, FAX: (519) 661-3175 University of Guelph, E-Mail: [email protected] University of Western Ontario, E-Mail: [email protected] Guelph, Ontario, N1G 2W1 London, Ontario, N6A 5C1. Vice-President Councillor Dr. David W. Andrews Tel: (905) 525-9140 Ext. 22075 Dr. Joseph R. Casey Tel: (780) 492-7203 Department of Biochemistry FAX: (905) 522-9033 Department of Physiology, FAX: (780)492-8915 McMaster University E-Mail:[email protected] University of Alberta, E-Mail: [email protected] 1200 Main St. W. Edmonton, Alberta, T6G 2H7 Hamilton, Ontario, L8N 3Z5 Councillor Treasurer Dr. Bruce L. Waygood Tel: (306) 966-8745 Dr. Fred B. Palmer, Tel: (902) 494-6436 (Office) Department of Biochemistry, FAX: (306) 966-4390 Department of Biochemistry, (902) 494-2570 (Lab) 107 Wiggins Road, E-Mail:[email protected] Dalhousie University, FAX: (902) 494-1355 University of Saskatchewan. Sir Charles Tupper Medical E-Mail: [email protected] Saskatoon, Saskatchewan, S7N 0W0 Bldg., Halifax, Nova Scotia, B3H 4H7 Chair, Nominating Committee Secretary Dr. Frances Sharom Dr. Eugene R. Tustanoff, Tel: (519) 471-1961 Department of Biochemistry, FAX: (519) 661-3175 BULLETIN Editor University of Western Ontario, E-Mail: [email protected] Dr. David O. Tinker Tel: (902) 532-2916 London, Ontario, N6A 5C1. 4311 Granville Road, E-Mail: [email protected] Granville Beach, Nova Scotia. B0S 1K0 Councillor Dr. Reinhart A. F. Reithmeier, Tel: (416) 978-7739 CFBS Head Office Membrane Biology Group, FAX: (416) 978-8765 Mrs. Wafaa Antonius, Tel: (613) 225-8889 Department of Medicine, E-Mail: [email protected] Office Manager, CFBS FAX: (613) 225-9621 University of Toronto, 104 - 1750 Courtwood E-Mail:[email protected] Toronto, Ontario, M5S 1A8. Crescent, Ottawa, Ontario, K2C 2B5 Councillor Dr. Robert M. Tanguay, Tel: (418) 656-3339 Laboratory of Cell & FAX: (418) 656 7176 Developmental Genetics, E-Mail: [email protected] Pavilon C.E. Marchand University of Laval, Ste. Foy, QC, G1K 7P4. 4 / CSBMCB/SCBBMC Bulletin 2001 CSBMCB President’s Report The bold step that your Society took to organ- strong team looking after the ize its own Annual Meeting has been a resounding details. Joel Weiner chairs the success so far. The Alliston meeting succeeded by Executive Committee, and any measure. The science was exceptional, the Mike Walsh chairs the Scien- venue was wonderful, the attendance was great, we tific Program Committee. They didn’t lose money (and may have made a bit) and will be calling upon members we attracted new members to the Society. We owe of the Society to contribute time a tremendous debt of gratitude to our three imme- and effort to help make the diate past-presidents for their outstanding work in meeting a success. Please be ensuring the success of the meeting. Peter Lewis generous in contributing to organized the program and obtained many of the make this the best International leaders in genomics, proteomics and bioinformatics Congress yet. We all owe a debt to speak. Peter Davies did an incredible job obtain- of gratitude to Peter Dolphin, ing contributions from a variety of sources to off- who played a key role in secur- set the costs of holding the meeting. Frances ing the Congress for Canada. Sharom worked with Council member Reinhart He will be missed by all of us. Reithmeier on the local arrangements. She also As I write this report, the arranged the highly successful Web registration events of September 11 in New York and Washing- Dr. Leon W. Browder process and upgraded the Web page, which served ton are all too fresh in our minds. The future has Department of an effective advertising function. become more unpredictable. As governments shift Biochemistry & Our next task is to host a successful their priorities and the economy absorbs these Molecular Biology Winternational Symposium March 21-24 in Banff, events, we may find that our jobs as advocates for University of Calgary which will serve as this year’s Annual Meeting. our disciplines become more difficult. But, as a Council has decided that the organization of two community , we will meet the challenge. Trivial meetings per year would be too large a burden for matters fade into insignificance, and family and an organization of this size. The Winternational in friends become our comfort zone. Banff will be followed in 2003 by the International I would be happy to hear from you at any Congress in Toronto in July. In 2004, the time. Your ideas and assistance for improving our Winternational will be held in Quebec. The 2005 effectiveness as a Society are always welcome. My meeting will be held in Central Canada, probably email address is [email protected]. returning to Alliston. Sincerely, The IUBMB Congress will be our overriding Leon Browder concern for the next year and a half. There is a CSBMCB/SCBBMC Bulletin 2001 / 5 Incoming Members of CSBMCB Executive Board 2001-2002 President of CSBMCB: When Leon was completing his