Supplemental Table 1: Differentially expressed genes between Kit+ and Kit- samples, FC > 2, p-value < 0.05, difference of mean > 100 Kit- Kit+ Probeset Symbol Genename FC pvalue diff (mean) (mean) 104280139 NA NA 130 1651 -12,70 0,0000 1520,78 5670239 Ear2 eosinophil-associated, ribonuclease A family, member 2 150 1848 -12,28 0,0000 1697,94 2340358 Ifitm3 interferon induced transmembrane protein 3 126 1315 -10,41 0,0000 1189,02 130465 NA NA 134 1155 -8,60 0,0000 1020,25 2360471 Ear1 eosinophil-associated, ribonuclease A family, member 1 155 1293 -8,34 0,0000 1137,61 7040095 Kit kit oncogene 409 3364 -8,22 0,0145 2955,05 1230347 LOC545854 NA 1216 9893 -8,14 0,0000 8677,76 2810059 Fcgr3a Fc fragment of IgG, low affinity IIIa, receptor 106 816 -7,73 0,0077 710,20 2510725 NA NA 394 2969 -7,53 0,0037 2574,43 5420372 NA NA 128 942 -7,33 0,0000 813,19 101990390 Ifitm2 interferon induced transmembrane protein 2 171 1181 -6,93 0,0000 1010,43 6510075 Ifitm1 interferon induced transmembrane protein 1 152 1054 -6,92 0,0004 901,68 2370286 Slc40a1 solute carrier family 40 (iron-regulated transporter), member 1 133 916 -6,91 0,0000 783,46 5860673 NA NA 143 985 -6,89 0,0239 842,27 6370309 LOC545854 NA 1850 12680 -6,85 0,0000 10829,66 101230129 Ear10 eosinophil-associated, ribonuclease A family, member 10 142 949 -6,68 0,0000 807,11 70112 S100a8 S100 calcium binding protein A8 (calgranulin A) 162 938 -5,79 0,0063 776,16 103780671 Mpeg1 macrophage expressed gene 1 105 598 -5,69 0,0000 493,10 1690184 NA NA 579 3042 -5,26 0,0002 2463,90 2450148 AI324046 expressed sequence AI324046 117 595 -5,10 0,0384 478,21 6380500 Il7r interleukin 7 receptor 237 1189 -5,03 0,0000 952,48 7050528 S100a9 S100 calcium binding protein A9 (calgranulin B) 123 609 -4,96 0,0193 485,92 2900450 Vcam1 vascular cell adhesion molecule 1 191 934 -4,90 0,0000 743,16 2120446 Slpi secretory leukocyte peptidase inhibitor 103 483 -4,69 0,0000 380,12 5270093 Cd81 CD 81 antigen 188 855 -4,55 0,0000 666,78 6860112 Lag3 lymphocyte-activation gene 3 126 534 -4,24 0,0000 408,30 5290673 H2-Aa histocompatibility 2, class II antigen A, alpha 547 2316 -4,24 0,0158 1769,04 2340093 Ifi27 interferon, alpha-inducible protein 27 309 1305 -4,23 0,0000 996,32 2650133 Ncf2 neutrophil cytosolic factor 2 306 1263 -4,13 0,0000 957,64 3120435 Nusap1 nucleolar and spindle associated protein 1 114 467 -4,11 0,0011 353,41 5890204 Prc1 protein regulator of cytokinesis 1 144 583 -4,05 0,0019 438,72 EGF-like module containing, mucin-like, hormone receptor- 1500592 Emr1 125 502 -4,02 0,0000 377,40 like sequence 1 104280301 Ifitm3 interferon induced transmembrane protein 3 114 459 -4,01 0,0026 344,36 2100403 Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C 246 980 -3,98 0,0000 733,83 100580541 9130211I03Rik RIKEN cDNA 9130211I03 gene 135 530 -3,93 0,0000 394,79 6940114 Ugt1a6b UDP glucuronosyltransferase 1 family, polypeptide A6B 366 1427 -3,90 0,0000 1060,83 103140402 Ifitm1 interferon induced transmembrane protein 1 81 316 -3,89 0,0000 234,91 105550685 NA NA 2299 8925 -3,88 0,0045 6625,82 4010739 NA NA 95 368 -3,87 0,0000 272,83 5130746 Tmem108 transmembrane protein 108 136 525 -3,86 0,0000 388,81 101660133 Hbb-b1 hemoglobin, beta adult major chain 430 1615 -3,76 0,0109 1185,29 6040164 NA NA 86 321 -3,71 0,0259 234,17 5700138 Bcl2a1d B-cell leukemia/lymphoma 2 related protein A1d 818 3029 -3,70 0,0000 2211,08 610270 Emb embigin 718 2645 -3,68 0,0000 1926,22 6590066 Pld4 phospholipase D family, member 4 102 374 -3,68 0,0001 272,39 2100619 NA NA 211 771 -3,66 0,0000 560,30 6550075 NA NA 1687 6086 -3,61 0,0249 4398,89 2900019 Plac8 placenta-specific 8 317 1141 -3,60 0,0001 824,66 60025 NA NA 121 425 -3,50 0,0004 303,40 1340239 Ear2 eosinophil-associated, ribonuclease A family, member 2 125 427 -3,42 0,0412 301,97 1770095 Axl AXL receptor tyrosine kinase 122 414 -3,38 0,0000 291,70 1740687 Hmox1 heme oxygenase (decycling) 1 145 474 -3,27 0,0281 328,98 105290301 Cd68 CD68 antigen 207 667 -3,23 0,0002 460,13 730301 Pscd3 pleckstrin homology, Sec7 and coiled-coil domains 3 233 751 -3,22 0,0000 517,78 2190563 Tubb6 tubulin, beta 6 229 736 -3,22 0,0000 507,35 1990524 Nupr1 nuclear protein 1 82 265 -3,21 0,0063 182,12 7000408 Bcl2a1a B-cell leukemia/lymphoma 2 related protein A1a 490 1569 -3,20 0,0039 1078,45 5360452 Tgm2 transglutaminase 2, C polypeptide 99 314 -3,17 0,0000 215,08 2360176 Mpo myeloperoxidase 104 330 -3,16 0,0179 225,77 2760440 Mpo myeloperoxidase 107 335 -3,14 0,0399 228,57 5860047 Casp4 caspase 4, apoptosis-related cysteine peptidase 220 683 -3,11 0,0000 463,25 3290014 Ttc3 tetratricopeptide repeat domain 3 237 738 -3,11 0,0000 500,46 2370092 Bcl2a1b B-cell leukemia/lymphoma 2 related protein A1b 1565 4864 -3,11 0,0010 3298,80 3170440 Alox5ap arachidonate 5-lipoxygenase activating protein 123 382 -3,11 0,0024 259,03 2230093 Ly86 lymphocyte antigen 86 113 351 -3,10 0,0000 237,81 1170390 Ifitm2 interferon induced transmembrane protein 2 96 294 -3,07 0,0000 198,15 1740056 Ctss cathepsin S 360 1101 -3,06 0,0474 740,92 940129 Gcnt1 glucosaminyl (N-acetyl) transferase 1, core 2 313 955 -3,05 0,0001 641,81 106940451 Pkp4 plakophilin 4 486 1475 -3,03 0,0000 988,46 1500687 Ctsz cathepsin Z 166 497 -3,00 0,0000 331,32 5270563 Rnase6 ribonuclease, RNase A family, 6 102 307 -3,00 0,0000 204,89 610398 Cxcl2 chemokine (C-X-C motif) ligand 2 132 396 -3,00 0,0453 263,73 2340110 Csf1r colony stimulating factor 1 receptor 109 326 -2,99 0,0000 217,09 4610019 Slc12a2 solute carrier family 12, member 2 122 360 -2,96 0,0000 238,77 4760168 Asb2 ankyrin repeat and SOCS box-containing protein 2 354 1044 -2,95 0,0000 690,10 5570112 Kif23 kinesin family member 23 185 547 -2,95 0,0001 361,78 1690458 Dtx3 deltex 3 homolog (Drosophila) 732 2132 -2,91 0,0000 1400,30 5220692 NA NA 262 757 -2,89 0,0016 495,47 103390167 NA NA 420 1209 -2,88 0,0041 788,93 1660593 Csf2 colony stimulating factor 2 (granulocyte-macrophage) 194 550 -2,83 0,0000 355,16 guanine nucleotide binding protein (G protein), gamma 540176 Gngt2 108 306 -2,83 0,0000 197,46 transducing activity polypeptide 2 50400 Suhw3 suppressor of hairy wing homolog 3 (Drosophila) 131 370 -2,83 0,0001 239,56 2360528 Rps17 ribosomal protein S17 3735 10546 -2,82 0,0006 6811,50 3840180 Cd274 CD274 antigen 553 1554 -2,81 0,0000 1001,89 6590537 Ctla4 cytotoxic T-lymphocyte-associated protein 4 99 276 -2,78 0,0099 176,77 6660451 Cd63 Cd63 antigen 94 260 -2,77 0,0000 166,34 6220722 Ebi2 Epstein-Barr virus induced gene 2 196 545 -2,77 0,0007 348,64 1050148 Rasgrp1 RAS guanyl releasing protein 1 1572 4321 -2,75 0,0003 2749,48 2650129 Mgst2 microsomal glutathione S-transferase 2 558 1527 -2,74 0,0001 969,35 1770551 E430002D04Rik RIKEN cDNA E430002D04 gene 88 241 -2,73 0,0000 152,48 104210204 Ear3 eosinophil-associated, ribonuclease A family, member 3 139 375 -2,70 0,0000 235,89 6110605 Ly6a lymphocyte antigen 6 complex, locus A 137 367 -2,68 0,0290 230,46 2320048 Cd96 CD96 antigen 311 831 -2,67 0,0001 520,11 4560632 Ckb creatine kinase, brain 250 666 -2,66 0,0002 415,45 103190092 Osmr oncostatin M receptor 98 257 -2,63 0,0000 159,37 2810739 Cd3d CD3 antigen, delta polypeptide 1114 2918 -2,62 0,0063 1803,35 1660176 Cyp4f18 cytochrome P450, family 4, subfamily f, polypeptide 18 118 306 -2,59 0,0000 187,90 1340324 Tnfrsf26 tumor necrosis factor receptor superfamily, member 26 195 504 -2,59 0,0000 308,83 2630075 Ugt1a6a UDP glucuronosyltransferase 1 family, polypeptide A6A 357 924 -2,59 0,0104 566,56 106100035 Sft2d2 SFT2 domain containing 2 772 2000 -2,59 0,0278 1228,01 1410056 Zc3h12d zinc finger CCCH type containing 12D 159 410 -2,57 0,0000 250,49 5670576 Hsp90b1 heat shock protein 90kDa beta (Grp94), member 1 988 2530 -2,56 0,0000 1542,27 360435 Hba-a1 hemoglobin alpha, adult chain 1 446 1134 -2,55 0,0119 688,58 5360450 Lmo2 LIM domain only 2 108 273 -2,54 0,0000 165,75 105570373 Hbb-b1 hemoglobin, beta adult major chain 493 1242 -2,52 0,0386 749,19 TPX2, microtubule-associated protein homolog (Xenopus 6420324 Tpx2 142 356 -2,51 0,0040 213,96 laevis) 5690551 2010300C02Rik RIKEN cDNA 2010300C02 gene 154 382 -2,48 0,0000 228,29 100450332 NA NA 194 480 -2,48 0,0000 285,96 6350176 Fcna ficolin A 84 209 -2,48 0,0086 124,62 4570739 Rab8b RAB8B, member RAS oncogene family 1485 3671 -2,47 0,0048 2186,36 100110411 Itgav integrin alpha V 152 375 -2,46 0,0025 222,48 4010088 Cdk2 cyclin-dependent kinase 2 312 766 -2,45 0,0000 453,79 2760019 Ifi205 interferon activated gene 205 1085 2653 -2,45 0,0000 1568,98 670358 Ear10 eosinophil-associated, ribonuclease A family, member 10 88 214 -2,43 0,0000 125,75 3390086 NA NA 608 1477 -2,43 0,0000 869,03 1660242 Uhrf1 ubiquitin-like, containing PHD and RING finger domains, 1 370 896 -2,42 0,0000 526,25 5270079 Rnf43 ring finger protein 43 377 909 -2,41 0,0090 532,15 110408 Birc5 baculoviral IAP repeat-containing 5 114 274 -2,40 0,0108 160,03 101500079 Cybb cytochrome b-245, beta polypeptide 98 235 -2,40 0,0125 136,89 5690528 Mns1 meiosis-specific nuclear structural protein 1 99 238 -2,39 0,0000 138,24 5690110 Pdcd4 programmed cell death 4 2613 6248 -2,39 0,0000 3635,70 3290541 NA NA 202 482 -2,39 0,0056 280,79 580446 Rbl2 retinoblastoma-like 2 661 1576 -2,38 0,0065 915,08 102510341 Hbb-b1 hemoglobin, beta adult major chain 423 1001 -2,37 0,0404 578,02 101990441 Fryl furry homolog-like (Drosophila) 153 363 -2,37 0,0421 210,00 7040450 Marcks myristoylated alanine rich protein kinase C substrate 120 281 -2,34 0,0000 161,33 6900112 Tgfbi transforming growth factor, beta induced 106 249 -2,34 0,0000 142,38 5670131 Cdca5 cell division cycle associated 5 119 277 -2,33 0,0000 158,12 5130315 Fcgrt Fc receptor, IgG, alpha chain transporter 137 320 -2,33 0,0000 182,60 1340132 NA NA 707 1645 -2,33 0,0000 938,07 2060102 NA NA 78 181 -2,33 0,0000 103,61 SPC24, NDC80 kinetochore complex component, homolog 4280451 Spc24 111 258 -2,33 0,0000 147,24 (S.