US009687573B2 (12) United States Patent (10) Patent No.: US 9,687,573 B2 Reb et al. (45) Date of Patent: Jun. 27, 2017 (54) COMPOSITIONS AND ASSOCIATED 5,762.903. A 6/1998 Parket al. METHODS FOR RADIOSOTOPE-BINDING 3. A 3. E. et al. e MCROPARTICLES 5,885,547 A 3/1999 Gray 5,888,546 A 3, 1999 Ji et al. (71) Applicant: Biosphere Medical, Inc., South Jordan, 5,894,022 A 4/1999 Ji et al. UT (US) 5,942,209 A 8, 1999 Leavitt et al. 6,015,541 A 1/2000 Greff et al. (72) Inventors: Philippe Reb, Themericourt (FR): 6,039,970 A 3/2000 Callegaro et al. Celine Chaix, Clichy la Garenne (FR) 6,060,040 A * 5/2000 Tournier ................ A61K424/9.364 49,06 6,083,495 A 7/2000 Holmes-Farley et al. (73) Assignee: Biosphere Medical, Inc., South Jordan, 6,099.457 A 8, 2000 Good UT (US) 6,103,295 A 8, 2000 Chan et al. 6,106,454. A 8/2000 Berg et al. (*) Notice: Subject to any disclaimer, the term of this 6,168,777 B1 1/2001 Greff et al. patent is extended or adjusted under 35 4.2.95. r. I R $39. 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