US 20150307617A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2015/0307617 A1 DU et al. (43) Pub. Date: Oct. 29, 2015 (54) ANTI-OX40ANTIBODIES AND METHODS OF cation No. 62/080,171, filed on Nov. 14, 2014, provi USE sional application No. 62/113,345, filed on Feb. 6, 2015. (71) Applicant: Genentech, Inc., South San Francisco, CA (US) Publication Classification (72) Inventors: Changchun DU, South San Francisco, (51) Int. Cl. CA (US); Jeong Kim, San Francisco, C07K 6/28 (2006.01) CA (US); Jing Zhu, Moraga, CA (US); A 6LX39/395 (2006.01) Jack Bevers, III, San Mateo, CA (US); C07K 6/30 (2006.01) Kevin Walsh, Walnut Creek, CA (US); A647/48 (2006.01) Patricia De Almeida, Pleasant Hill, CA A6II 45/06 (2006.01) (US); James Andya, Millbrae, CA (US); (52) U.S. Cl. Ye Shen, Daly City, CA (US) CPC ....... C07K 16/2878 (2013.01); A61K 47/48561 2013.O1): 46 IK 47/48.384 (2013.O1): 46II (73) Assignee: Genentech, Inc., South San Francisco, isi, 38-6. C07K 6/30 38. A61 K CA (US) 39/39558 (2013.01); A61 K39/3955 (2013.01); C07K 16/3069 (2013.01); C07K 2317/92 (21) Appl. No.: 14/673,792 (2013.01); C07K 2317/75 (2013.01); C07K 1-1. 2317/71 (2013.01); C07K 2317/56 (2013.01); (22)22) FileFiled: Marar, 30,5U, 2015 C07K 2317/51 (2013.01);s C07K 2317/515s Related U.S. Application Data (2013.01); A61K 2039/505 (2013.01) (60) Provisional application No. 61/973,193, filed on Mar. (57) ABSTRACT 31, 2014, provisional application No. 61/989,448, filed on May 6, 2014, provisional application No. The invention provides anti-OX40 antibodies and methods of 62/073,873, filed on Oct. 31, 2014, provisional appli using the same. Patent Application Publication Oct. 29, 2015 Sheet 1 of 39 US 2015/0307617 A1 Hyb 1A7 ?unoo ?unoO ?unoo FIG. 1 Patent Application Publication Oct. 29, 2015 Sheet 2 of 39 US 2015/0307617 A1 100 101 102 103 104 FIG. 1 (Cont.) 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