WHO Drug Information Vol. 04, No. 4, 1990

WHO Drug Information Vol. 04, No. 4, 1990

WHO DRUG INFORMATION VOLUME 4 • NUMBER 4 • 1990 PROPOSED INN LIST 64 INTERNATIONAL NONPROPRIETARY NAMES FOR PHARMACEUTICAL SUBSTANCES WORLD HEALTH ORGANIZATION • GENEVA WHO Drug Information WHO Drug Information provides an cerned with the rational use of overview of topics relating to drug drugs. In effect, the journal seeks development and regulation that to relate regulatory activity to are of current relevance and im­ therapeutic practice. It also aims to portance, and will include the lists provide an open forum for debate. of proposed and recommended In­ Invited contributions will portray a ternational Nonproprietary Names variety of viewpoints on matters of for Pharmaceutical Substances general policy with the aim of (INN). Its contents reflect, but do stimulating discussion not only in not present, WHO policies and ac­ these columns but wherever rel­ tivities and they embrace socio­ evant decisions on this subject economic as well as technical mat­ have to be taken. ters. WHO Drug Information is pub­ The objective is to bring issues that lished 4 times a year in English are of primary concern to drug and French. regulators and pharmaceutical manufacturers to the attention of a Annual subscription: Sw.fr. 50.— wide audience of health profes­ Airmail rate: Sw.fr. 60.— sionals and policy-makers con­ Price per copy: Sw.fr. 15.— © World Health Organization 1990 Authors alone are responsible for views expressed Publications of the World Health Organization in signed contributions. enjoy copyright protection in accordance with the provisions of Protocol 2 of the Universal The mention of specific companies or of certain Copyright Convention. For rights of reproduc­ manufacturers' products does not imply that they are tion or translation, in part or in toto, applica­ endorsed or recommended by the World Health tion should be made to: Chief, Office of Organization in preference to others of a similar na­ Publications, World Health Organization, ture which are not mentioned. Errors and omissions 1211 Geneva 27, Switzerland. The World excepted, the names of proprietary products are Health Organization welcomes such applica­ distinguished by initial capital letters. tions. The designations employed and the presen­ tation of the material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the World Health Organization concerning the legal status of any country, territory, city, or area or of its authorities, or concern­ ing the delimitation of its frontiers or boun­ daries. ISSN 1010-9609 World Health Organization, Geneva WHO Drug Information Volume 4, 1990: Index A Cilastatin, (2) 73 Citiolone, reactions, (2) 72 ACE-inhibitors, (1) 23 Clinical pharmacology, (2) 43 Acetylsalicylic acid, ADR, (1) 9 Clodronate, (4) 171 eclampsia, (1) 11 Clozapine, (1) 23, (4) 177 thrombolysis (4) 167 Combinations, analgesics, (2) 64 Acitretin, (4) 175 Contraceptive, age limit, (1) 29 Adenosine deaminase, (2) 64 implantable, (4) 176 ADR, international reporting, (3) 135 metabolic effects, (4) 164 monitoring centre, (2) 45 mortality trends, (1) 13 AIDS update, (1) 23 Corticosteroids, (2) Aluminium content, (2) 70 Pneumocystis pneumonia, (4) 178 Amphotericin B, (4) 164 Cost, antihypertensives, (1) 18 leishmaniasis, (2) 54 Cytomegalovirus immune globulin, (2) 65 Antibiotics, caesarian section, (1) 22 Cytostatic agents, (3) 111 cost, (3) 124 endocarditis, (2) 70 prescribing, (3) 120 D rational use, (1) 4 Degradation, (1) 18 red eyes, (3) 110 Development and tropical disease, (3) 105 Anticonvulsants and teratogenicity, (2) 51 Digoxin, (3) 107 Antimony regimens, (4) 163 Disaster drug supply, (2) 62 Audit, (1) 21 Disintegration of tablets, (2) 65 Distribution, Nigeria, (1) 42 B Doxycycline, (1) 28 Drug master files on active ingredients, (1) 17 Barbiturates, (3) 126 Drug utilization, (1) 19 BCG instillation, (2) 64 leishmaniasis, (2) 55 vaccine, (1) 40 E Beclobrate, (4) 175 Eflornithine, (1) 12, (4) 175 Benzodiazepine, (2) 53 Encainide, (1) 24 Beta adrenoreceptor blocking agent, (2) 71. (2) 52 Epidemiology, (1) 42, (3) 124 Bioequivalence testing, (4) 175 Epoetin alfa, (2) 65 Biperiden, (2) 71 Ethambutol, mycobacteria, (2) 77 parkinsonism, (3) 133 tuberculosis (1) 39 Blood products, (3) 122 Etidronate, (4) 171 Bronchodilators, (2) 71 F c Fecainide, (1) 24 Calcium channel blocking agents, Fenoterol, (2) 65 antihypertensive, (2) 56 asthma, (1) 24 atherosclerosis, (3) 113 Floctafenine, (1) 28 Cancer in elderly, (3) 125 Flourouracil, (3) 127 Carbamazepine, stability, (2) 72 Flucloxacillin, (2) 72, (4) 177 Carbidopa, parkinsonism, (3) 132 Fluconazole, (1) 25 Cefalosporins, (1) 28 Fludarabine, (1) 25 Chemotherapy, leukaemia, (1) 15 Formularies, (1) 19 lung cancer, (1) 20 Fumaric acid, (1) 28 Chloroquine, abuse, (1) 9 Furazolidone, (4) 184 i.m., (1) 10 Furosemide, (4) 171 resistance, (1) 15, (1) 8 Cholera, (4) 180 1 WHO Drug Information Volume 4, Index 1990 G N Generic quality, (3) 129 Natural medicines, Sweden, (1) 29 Germanium poisoning, (1) 25 Nicotinic acid, (3) 129, (4) 161 Glafenine, (1) 28 Nikethamide, withdrawal, (1) 29 Gold salt, leishmaniasis, (2) 55 Nitroprusside toxicity, (4) 176 Granulocyte macrophage colony stimulating factor, (3) 126 Guar gum, (3) 126 O H Oral rehydration salts, (4) 181 H. Influenzae conjugate vaccines, (4) 160 Orphan drugs, (2) 60 Hepatitis C tests, (3) 127 HUV-2 test, (2) 73 P Pamidronate, (4) 171 I Parkinsonism, (3) 131 Patient information, (2) 61 Ibuprofen, (2) 66 Pentamidine, leishmaniasis, (2) 54 Imipenem, (2) 73 Pertussis vaccine, (2) 49 Ingredients, (1) 17 Pharmacy, (3) 103 Interferon alfa, HIV, (3) 112 Phenolic throat sprays, (2) 67 low-dose, oral, AIDS, (3) 110 Pirprofen, (2) 74 Interferon gamma, leishmaniasis, (2) 55 Prescribing in elderly, (3) 123 Intrauterine devices, (2) 52 Prescription costs, (2) 61 Isomerism, (2) 58 Pricing of pharmaceuticals, (4) 170 Isoniazid, mycobacteria, (2) 78 Promethazine, (1) 26 tuberculosis (1) 33 Pyrazinamide, tuberculosis (1) 37 Isotretinoin, (2) 73 Pyrimethamine, (1) 8 Ivermectin, community therapy, (2) 48 pregnancy, (4) 162 Q K Quinine, i.m., (1) 10 parenteral, (2) 54 Ketoconazole, (1) 25 L R Ranitidine, (1) 14 Labelling, Ireland, (1) 25 Refugee requirements, (3) 117 Levamisole, (3) 127 Regulation, FDA, (2) 80 Levodopa, parkinsonism, (3) 132 Rifampicin, mycobacteria, (2) 76 Lipid-lowering agents, (3) 108, (3) 114 tuberculosis (1) 36 Liquid paraffin, (2) 66 Lithium, suicide, (2) 52 Loperamide, (1) 12, (2) 73 S Lovastatin, (4) 161 Silfamethoxazole + trimethoprim, (4) 183 Skin bleaching agents, (2) 47 M Sodium oxybate, (4) 177 Specifications for pharmaceutical preparations, (4) 185 Management of acute diarrhoea in children, (4) 185 Spurious drugs, (3) 135 Melarsoprol, (1) 12 Stevens-Johnson syndrome, profile, (3) 130 Mesalazine, (4) 177 Streptomycin, tuberculosis (1) 38 Methylene blue, (2) 66 Metoclopramide, (1) 26, (1) 29, (2) 74 Misoprosol, (1) 14 T Molsidomine, (1) 26 Tablets in the tropics, (4) 186 Monoclonal antibody: Gram-negative endotoxins, (4) 173 Tamoxifen, (3) 127 Multiple drug resistance, (3) 121 Teratology information, (4) 170 Mycobacteria, (2) 75 Tetracycline, (4) 2 WHO Drug Information Volume 3, Index 1990 The pharmacological basis of therapeutics, (4) 186 Triazolam, (2) 67 W Trimethoprim-sulfamethoxazole, (1) 26, (2) 67 Warfarin, (4) 168 L-tryptophan, (2) 67 WHO Certification Scheme, (1) 1 update, (1) 27 provisional guidelines, (4) 149 Tuberculosis, (1) 30 V Xamoterol, (2) 68 Vaccine, BCG, (1) 40 H. Influenzae conjugate, (4) 160 hepatitis B, (3) 129 Zidovudine, (1) 27, (3) 128 influenza, 91) 28 Zopiclone, (4) 179 pertussis, (2) 49 typhoid, (1) 26 Vitamin A, (3) 130, (4) 165 3 Volume 4, Number 4, 1990 World Health Organization, Geneva WHO Drug Information Contents General Policy Topics Advisory Notices Further proposals on the Clozapine-induced neutropenia 177 WHO Certification Scheme 149 Flucloxacillin hepatitis 177 Sodium oxybate: evidence of abuse 177 Reports on Individual Drugs Mesalazine nephrotoxicity 177 H. influenzae conjugate vaccines: Corticosteroid cover during treatment of setbacks and successes 160 Pneumocystis pneumonia 178 Treatment of hyperlipidaemia in Zopiclone and neuropsychiatric reactions 179 high-risk patients 160 The safety of ivermectin in pregnancy 162 Essential Drugs Failure of antimony regimens in Cholera: the need for preparedness 180 advanced mucosal leishmaniasis 163 Oral rehydration salts 181 Oral contraceptives: the significance Tetracycline 182 of metabolic effects 164 Doxycycline 183 Vitamin A: malnutrition and infection 165 Sulfamethoxazole + trimethoprim 183 More on acetylsalicylic acid and thrombolysis 167 Furazolidone 184 Anticoagulation in nonrheumatic atrial fibrillation 168 Recent Publications Management of acute diarrhoea in children 185 General Information Specifications for pharmaceutical preparations 185 Pricing of pharmaceuticals 170 Tablets in the tropics 186 Teratology information services 170 The pharmacological basis of therapeutics 186 Hypercalcaemia and cancer 171 Prevention of bacterial endocarditis 172 Gram-negative sepsis and monoclonal Proposed International antibodies 172 Nonproprietary Names: List 64 Regulatory Matters Acitretin: confusion over the teratogenic risk 175 Beclobrate: withdrawal following cases of hepatitis 175 Tighter rules for bioequivalence testing 175 Eflornithine for Gambian trypanosomiasis 175 Nitroprusside and cyanide toxicity 176 Implantable contraceptive system approved 176 WHO Drug Information Vol. 4, No. 4, 1990 General Policy Topics Further

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