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(Circulation . 1998 ; 97 : 900 - 906 ) . * 28 , 2013 NM _ 001098635 — Homo sapiens seizure related 6 homolog (51 ) Int . Ci. (SEZ6 ) , transcript variant 2 , mRNA . NM _ 021286 — Mus musculus seizure related gene 6 (Sezo ) , tran CO7K 16 / 00 ( 2006 .01 ) script variant 1 , mRNA . A61K 4748 ( 2006 . 01) NM _ 178860 — Homo sapiens seizure related 6 homolog (SEZO ) , CO7K 16 / 28 ( 2006 .01 ) transcript variant 1 , mRNA . GOIN 33 / 574 ( 2006 .01 ) NP _ 001092105 — seizure protein 6 homolog isoform 2 precursor CO7K 16 / 18 ( 2006 .01 ) [Homo sapiens ] . A61K 47 /68 ( 2017 . 01 ) NP _ 001099224 — seizure protein 6 homolog precursor [Rattus A61K 39 / 00 ( 2006 . 01 ) norvegicus ] . ( 52 ) U . S . CI. (Continued ) CPC . .. A61K 47 /48384 ( 2013 .01 ) ; A61K 47/ 6803 ( 2017 .08 ) ; A61K 47 /6843 ( 2017 .08 ); A61K 47 /6849 ( 2017 . 08 ) ; CO7K 16 / 18 ( 2013 .01 ) ; Primary Examiner — Brad Duffy CO7K 16 / 28 ( 2013 .01 ) ; GOIN 33 / 57407 (74 ) Attorney , Agent, or Firm — Womble Bond Dickinson (2013 .01 ) ; GOIN 33 /57423 ( 2013 .01 ) ; A61K (US ) LLP 2039 / 505 ( 2013 .01 ) ; CO7K 2317 /20 ( 2013 .01 ) ; CO7K 2317 / 24 ( 2013 .01 ) ; CO7K 2317 / 33 (57 ) ABSTRACT ( 2013 .01 ) ; CO7K 2317 / 34 ( 2013 .01 ) ; CO7K 2317 / 565 (2013 . 01 ) ; COZK 2317 /73 ( 2013 .01 ) ; Novel modulators , including antibodies and derivatives CO7K 2317 /77 (2013 .01 ) thereof , and methods of using such modulators to treat (58 ) Field of Classification Search proliferative disorders are provided . None See application file for complete search history . 41 Claims, 72 Drawing Sheets US 9 ,993 ,566 B2 Page 2 ( 56 ) References Cited Bork et al ., “ The CUB domain . 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