Anti-C4B monoclonal antibody, clone FQS21254 (DCABH-5518) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Rabbit monoclonal to C4a Antigen Description C4 plays a central role in the activation of the classical pathway of the complement system. It is processed by activated C1 which removes from the alpha chain the C4a anaphylatoxin. The remaining alpha chain fragment C4b is the major activation product and is an essential subunit of the C3 convertase (C4b2a) and the C5 convertase (C3bC4b2a) enzymes of the classical complement pathway.Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. Immunogen Recombinant fragment within Human C4a. The exact sequence is proprietary.Database link: P0C0L4 Isotype IgG Source/Host Rabbit Species Reactivity Human Clone FQS21254 Purity Tissue culture supernatant Conjugate Unconjugated Applications Flow Cyt, IHC-P, WB Positive Control HepG2 cell lysate; Human colon and stomach tissues; HepG2 cells. Format Liquid Size 100 μl Buffer Preservative: 0.01% Sodium azide; Constituents: 50% Glycerol, 0.05% BSA Preservative 0.01% Sodium Azide Storage Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Ship Shipped at 4°C. GENE INFORMATION Gene Name C4B complement component 4B (Chido blood group) [ Homo sapiens ] Official Symbol C4B Synonyms C4B; complement component 4B (Chido blood group); complement component 4B; complement C4-B; C4B1; C4B3; C4F; CH; CO4; CPAMD3; Chido form of C4; complement C4B1a; basic complement C4; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3; C4B2; Entrez Gene ID 721 Protein Refseq NP_001002029 UniProt ID P0C0L4 Chromosome Location 6p21.3 Pathway Complement Activation, Classical Pathway, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Pertussis, organism-specific biosystem; Pertussis, conserved biosystem; SIDS Susceptibility Pathways, organism-specific biosystem; Staphylococcus aureus infection, organism-specific biosystem; Function endopeptidase inhibitor activity; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.