Natural Compounds as Antimicrobial Agents • Carlos M. and Franco Beatriz Vázquez Belda Natural Compounds as Antimicrobial Agents Edited by Carlos M. Franco and Beatriz Vázquez Belda Printed Edition of the Special Issue Published in Antibiotics www.mdpi.com/journal/antibiotics Natural Compounds as Antimicrobial Agents Natural Compounds as Antimicrobial Agents Special Issue Editors Carlos M. Franco Beatriz V´azquezBelda MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade • Manchester • Tokyo • Cluj • Tianjin Special Issue Editors Carlos M. Franco Beatriz V´azquez Belda University of Santiago de Compostela University of Santiago de Compostela Spain Spain Editorial Office MDPI St. Alban-Anlage 66 4052 Basel, Switzerland This is a reprint of articles from the Special Issue published online in the open access journal Antibiotics (ISSN 2079-6382) (available at: https://www.mdpi.com/journal/antibiotics/special issues/natural compounds agents). For citation purposes, cite each article independently as indicated on the article page online and as indicated below: LastName, A.A.; LastName, B.B.; LastName, C.C. Article Title. Journal Name Year, Article Number, Page Range. ISBN 978-3-03936-048-2 (Hbk) ISBN 978-3-03936-049-9 (PDF) Cover image courtesy of Gang Pan. c 2020 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND. Contents About the Special Issue Editors ..................................... vii Carlos Manuel Franco and Beatriz I. V´azquez Natural Compounds as Antimicrobial Agents Reprinted from: Antibiotics 2020, 9, 217, doi:10.3390/antibiotics9050217 ............... 1 Suresh Mickymaray Efficacy and Mechanism of Traditional Medicinal Plants and Bioactive Compounds against Clinically Important Pathogens Reprinted from: Antibiotics 2019, 8, 257, doi:10.3390/antibiotics8040257 ............... 5 Emiliano J. Quinto, Irma Caro, Luz H. Villalobos-Delgado, Javier Mateo, Beatriz De-Mateo-Silleras and Mar´ıa P. Redondo-Del-R´ıo Food Safety through Natural Antimicrobials Reprinted from: Antibiotics 2019, 8, 208, doi:10.3390/antibiotics8040208 ............... 63 Heather A. Pendergrass and Aaron E. May Natural Product Type III Secretion System Inhibitors Reprinted from: Antibiotics 2019, 8, 162, doi:10.3390/antibiotics8040162 ............... 93 Ibtissem Djinni, Andrea Defant, Mouloud Kecha and Ines Mancini Actinobacteria Derived from Algerian Ecosystems as a Prominent Source of Antimicrobial Molecules Reprinted from: Antibiotics 2019, 8, 172, doi:10.3390/antibiotics8040172 ...............107 Sudarshan Singh Thapa and Anne Grove Do Global Regulators Hold the Key to Production of Bacterial Secondary Metabolites? Reprinted from: Antibiotics 2019, 8, 160, doi:10.3390/antibiotics8040160 ...............131 Rosa Luisa Ambrosio, Lorena Gratino, Sara Mirino, Ennio Cocca, Antonino Pollio, Aniello Anastasio, Gianna Palmieri, Marco Balestrieri, Angelo Genovese and Marta Gogliettino The Bactericidal Activity of Protein Extracts from Loranthus europaeus Berries: A Natural Resource of Bioactive Compounds Reprinted from: Antibiotics 2020, 9, 47, doi:10.3390/antibiotics9020047 ................151 .Nasir Mahmood, Ruqia Nazir, Muslim Khan, Abdul Khaliq, Mohammad Adnan, Mohib Ullah and Hongyi Yang Antibacterial Activities, Phytochemical Screening and Metal Analysis of Medicinal Plants: Traditional Recipes Used against Diarrhea Reprinted from: Antibiotics 2019, 8, 194, doi:10.3390/antibiotics8040194 ...............165 Reuven Rasooly, Adel Molnar, Hwang-Yong Choi, Paula Do, Kenneth Racicot and Emmanouil Apostolidis In-Vitro Inhibition of Staphylococcal Pathogenesis by Witch-Hazel and Green Tea Extracts Reprinted from: Antibiotics 2019, 8, 244, doi:10.3390/antibiotics8040244 ...............181 Lizbeth Anah´ı Portillo-Torres, Aurea Bernardino-Nicanor, Carlos Alberto G´omez-Aldapa, Simplicio Gonz´alez-Montiel, Esmeralda Rangel-Vargas, Jos´e Roberto Villag´omez-Ibarra, Leopoldo Gonz´alez-Cruz,Humberto Cort´es-L´opezand Javier Castro-Rosas Hibiscus Acid and Chromatographic Fractions from Hibiscus Sabdariffa Calyces: Antimicrobial Activity against Multidrug-Resistant Pathogenic Bacteria Reprinted from: Antibiotics 2019, 8, 218, doi:10.3390/antibiotics8040218 ...............193 v Mohammadreza Khoobani, Seyyed-Hamed Hasheminezhad, Faramin Javandel, Mehran Nosrati, Alireza Seidavi, Isam T. Kadim, Vito Laudadio and Vincenzo Tufarelli Effects of Dietary Chicory (Chicorium intybus L.) and Probiotic Blend as Natural Feed Additives on Performance Traits, Blood Biochemistry, and Gut Microbiota of Broiler Chickens Reprinted from: Antibiotics 2020, 9, 5, doi:10.3390/antibiotics9010005 ................211 Agust´ınRebollada-Merino, Carmen B´arcena,Mar´ıaUgarte-Ruiz, N´estorPorras, Francisco J. Mayoral-Alegre, Irene Tom´e-S´anchez,Lucas Dom´ınguezand Antonio Rodr´ıguez-Bertos Effects on Intestinal Mucosal Morphology, Productive Parameters and Microbiota Composition after Supplementation with Fermented Defatted Alperujo (FDA) in Laying Hens Reprinted from: Antibiotics 2019, 8, 215, doi:10.3390/antibiotics8040215 ...............221 Alexandre Lamas, Patricia Regal, Beatriz V´azquez, Alberto Cepeda and Carlos Manuel Franco Short Chain Fatty Acids Commonly Produced by Gut Microbiota Influence Salmonella enterica Motility, Biofilm Formation, and Gene Expression Reprinted from: Antibiotics 2019, 8, 265, doi:10.3390/antibiotics8040265 ...............233 Liliana Fernandes, Ana Oliveira, Mariana Henriques and Maria Elisa Rodrigues Honey as a Strategy to Fight Candida tropicalis in Mixed-Biofilms with Pseudomonas aeruginosa Reprinted from: Antibiotics 2020, 9, 43, doi:10.3390/antibiotics9020043 ................247 Valeria Di Onofrio, Renato Gesuele, Angela Maione, Giorgio Liguori, Renato Liguori, Marco Guida, Roberto Nigro and Emilia Galdiero Prevention of Pseudomonas aeruginosa Biofilm Formation on Soft Contact Lenses by Allium sativum Fermented Extract (BGE) and Cannabinol Oil Extract (CBD) Reprinted from: Antibiotics 2019, 8, 258, doi:10.3390/antibiotics8040258 ...............259 Diego E. Carballo, Javier Mateo, Sonia Andr´es,Francisco Javier Gir´aldez,Emiliano J. Quinto, Ali Khanjari, Sabina Operta and Irma Caro Microbial Growth and Biogenic Amine Production in a Balkan-Style Fresh Sausage during Refrigerated Storage under a CO2-Containing Anaerobic Atmosphere: Effect of the Addition of Zataria multiflora Essential Oil and Hops Extract Reprinted from: Antibiotics 2019, 8, 227, doi:10.3390/antibiotics8040227 ...............271 Laura Buz´on-Dur´an,Jes ´usMart´ın-Gil,Eduardo P´erez-Lebe˜na,David Ruano-Rosa, Jos´eL. Revuelta, Jos´eCasanova-Gasc´on,M. Carmen Ramos-S´anchezand Pablo Mart´ın-Ramos Antifungal Agents Based on Chitosan Oligomers, ε-polylysine and Streptomyces spp. Secondary Metabolites against Three Botryosphaeriaceae Species Reprinted from: Antibiotics 2019, 8, 99, doi:10.3390/antibiotics8030099 ................287 Kenta Kotani, Mio Matsumura, Yuji Morita, Junko Tomida, Ryo Kutsuna, Kunihiko Nishino, Shuji Yasuike and Yoshiaki Kawamura 13-(2-Methylbenzyl) Berberine Is a More Potent Inhibitor of MexXY-Dependent Aminoglycoside Resistance than Berberine Reprinted from: Antibiotics 2019, 8, 212, doi:10.3390/antibiotics8040212 ...............301 vi About the Special Issue Editors Carlos M. Franco graduated in veterinary medicine and finished his Ph.D. at the University of Santiago de Compostela, Spain, in 1994, with a thesis regarding L. monocytogenes incidence in food as well as resistance to several antimicrobials. He completed his posdoctoral studies at the Veterinary Faculty of the Complutense University of Madrid, completing his formation in several food microbiology aspects as well as at the Laboratory of Chimie Analityque II of the University of Paris 11, where he studied several analytical methods. Subsequently, he was interested in antimicrobial resistance, the effect of the use of antibiotics in animal production, and antimicrobial resistance in food from ecological or conventional origins. He has researched the detection of antimicrobials and other drugs in food of animal origin as well as the effect of essential oils on the inhibition of bacteria. He has published more than 120 peer-reviewed papers. Currently, he is researching bacterial biofilms and their elimination or control as well as other food science topics. Beatriz V´azquez Belda holds degrees in biology and in food technology and obtained her Ph.D. in 1997 at the Santiago de Compostela University (USC), Spain. She completed her posdoctoral studies at the Ecole Nationale d’Industrie Laitiere` et des Industries Agro-alimentaires (Surgeres,` France) and at the Faculte´ des Sciences Pharmaceutiques et Biologiques (Paris, France). She specializes in food micology, studying fungal contamination on Spanish cheeses as well as the development of fast detection techniques using microbiological and instrumental methods, taking advantage of the luminescence properties of aflatoxins as well as other micotoxins. After two years as lecturer at the Cardenal Herrera-CEU University at Valencia, she returned to the Veterinary Faculty (USC) with a Ramon y Cajal national grant. She continued her interest in researching the use of natural compounds