SUPPLEMENTARY TABLE I: Genes dysregulated with overexpression of HIF-2α in LP-1 cells. GeneID Gene Symbol Gene Name Fold Change Regulation in LP-1-HIF2A NM_001430 EPAS1 endothelial PAS domain protein 1/hypoxia-inducible factor 2α 40.71 up NM_001295 CCR1 chemokine (C-C motif) receptor 1 6.48 up NM_001010923 THEMIS thymocyte selection associated 5.14 up NM_000609 CXCL12 chemokine (C-X-C motif) ligand 12 4.65 up NM_017738 CNTLN centlein, centrosomal protein 4.03 up NM_001012301 ARSI arylsulfatase family, member I 3.99 up 10628 TXNIP thioredoxin interacting protein 3.81 up NM_003633 ENC1 ectodermal-neural cortex 1 (with BTB domain) 3.38 up NM_000351 STS steroid sulfatase (microsomal), isozyme S 3.23 up NM_007315 STAT1 signal transducer and activator of transcription 1 3.19 up NM_001175 ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 3.14 up NM_021982 SEC24A SEC24 family member A 3.04 up NM_001876 CPT1A carnitine palmitoyltransferase 1A 3.01 up 57226 LYRM2 LYR motif containing 2 2.99 up NM_019058 DDIT4 DNA-damage-inducible transcript 4 2.96 up NM_004419 DUSP5 dual specificity phosphatase 5 2.88 up NM_021623 PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 2.74 up NM_022350 ERAP2 endoplasmic reticulum aminopeptidase 2 2.73 up NM_005779 LHFPL2 lipoma HMGIC fusion partner-like 2 2.68 up NM_197947 CLEC7A C-type lectin domain family 7, member A 2.67 up ENST00000334286 EDNRB endothelin receptor type B 2.62 up AK289800 SLC35D1 solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1 2.60 up NM_001866 COX7B cytochrome c oxidase subunit VIIb 2.60 up NM_001584 MPPED2 metallophosphoesterase domain containing 2 2.58 up XM_937293 ANKRD11 ankyrin repeat domain 11 2.49 up 348487 FAM131C family with sequence similarity 131, member C 2.49 up NM_002154 HSPA4 heat shock 70kDa protein 4 2.48 up NM_005606 LGMN legumain 2.44 up NM_025216 WNT10A wingless-type MMTV integration site family, member 10A 2.42 up NM_152289 ZNF561/ZNF562 zinc finger protein 561/zinc finger protein 562 2.41 up NM_002610 PDK1 pyruvate dehydrogenase kinase, isozyme 1 2.40 up NM_001008701 LPHN1 latrophilin 1 2.38 up NM_207459 TEX19 testis expressed 19 2.37 up NM_001144 AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 2.32 up NM_002287 LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.31 up NM_002119 HLA-DOA major histocompatibility complex, class II, DO alpha 2.30 up NM_001903 CTNNA1 catenin (cadherin-associated protein), alpha 1 2.27 up NM_012288 TRAM2 translocation associated membrane protein 2 2.26 up NM_004566 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 2.25 up NM_000917 P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.25 up NM_001099432 BCAS3 breast carcinoma amplified sequence 3 2.24 up NR_003006 SCARNA6 small Cajal body-specific RNA 6 2.24 up NM_006618 KDM5B lysine (K)-specific demethylase 5B 2.24 up GeneID Gene Symbol Gene Name Fold Change Regulation in LP-1-HIF2A NM_018433 KDM3A lysine (K)-specific demethylase 3A 2.23 up NM_052916 RNF157 ring finger protein 157 2.23 up NM_177401 MIDN midnolin 2.22 up NM_006290 TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.21 up NM_002906 RDX radixin 2.21 up NM_006227 PLTP phospholipid transfer protein 2.19 up NM_004910 PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 2.19 up NM_017751 SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.18 up NM_014488 RAB30 RAB30, member RAS oncogene family 2.18 up BC035599 C2CD3 C2 calcium-dependent domain containing 3 2.18 up 54587 MXRA8 matrix-remodelling associated 8 2.17 up 0 ZNF865 zinc finger protein 865 2.17 up NM_001040455 SIDT2 SID1 transmembrane family, member 2 2.13 up NM_213560 PKN1 protein kinase N1 2.12 up NM_001013840 TCTN3 tectonic family member 3 2.12 up BC019669 EEF1A1 eukaryotic translation elongation factor 1 alpha 1 2.11 up NM_003387 WIPF1 WAS/WASL interacting protein family, member 1 2.09 up BC005028 PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 2.08 up NM_004199 P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.06 up NM_145059 FUK fucokinase 2.05 up XM_938688 LOC101927789 putative ubiquitin-like protein FUBI-like protein ENSP00000310146-like 2.05 up NM_003900 SQSTM1 sequestosome 1 2.04 up NM_001007073 RPL32 ribosomal protein L32 2.04 up NM_022478 CDH24 cadherin 24, type 2 2.04 up NM_018427 RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) 2.04 up NM_018712 ELMOD1 ELMO/CED-12 domain containing 1 2.04 up NM_006480 RGS14 regulator of G-protein signaling 14 2.03 up 493 ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 2.02 up NM_012292 HMHA1 histocompatibility (minor) HA-1 2.02 up NM_018343 RIOK2 RIO kinase 2 2.02 up NM_001037633 SIL1 SIL1 nucleotide exchange factor 2.02 up NM_016170 TLX2 T-cell leukemia homeobox 2 2.02 up NM_024503 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2.02 up NM_000112 SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.01 up BC036925 HARBI1 harbinger transposase derived 1 2.00 up NM_016113 TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.00 up NM_001182 ALDH7A1 aldehyde dehydrogenase 7 family, member A1 7.88 down 57823 SLAMF7 SLAM family member 7 5.25 down NM_002966 S100A10 S100 calcium binding protein A10 4.87 down NM_005952 MT1X metallothionein 1X 3.58 down NM_001002858 ANXA2 annexin A2 3.52 down NM_052966 FAM129A family with sequence similarity 129, member A 3.26 down NM_031479 INHBE inhibin, beta E 3.17 down NM_178012 TUBB2B tubulin, beta 2B class IIb 3.16 down GeneID Gene Symbol Gene Name Fold Change Regulation in LP-1-HIF2A NM_005045 RELN reelin 3.07 down NM_206953 PRAME preferentially expressed antigen in melanoma 3.07 down NM_005620 S100A11 S100 calcium binding protein A11 3.06 down NM_017918 CCDC109B coiled-coil domain containing 109B 3.06 down NM_001336 CTSZ cathepsin Z 2.97 down NM_058179 PSAT1 phosphoserine aminotransferase 1 2.93 down NM_007069 PLA2G16 phospholipase A2, group XVI 2.90 down NM_006745 MSMO1 methylsterol monooxygenase 1 2.88 down --- ZNF626 zinc finger protein 626 2.86 down NM_015535 SPATS2L spermatogenesis associated, serine-rich 2-like 2.84 down NM_014278 HSPA4L heat shock 70kDa protein 4-like 2.82 down NM_018248 NEIL3 nei endonuclease VIII-like 3 2.77 down NM_024642 GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 2.73 down NM_021021 SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 2.62 down BC007034 MT2A metallothionein 2A 2.50 down NM_015954 DERA deoxyribose-phosphate aldolase (putative) 2.49 down NM_198336 INSIG1 insulin induced gene 1 2.48 down NM_017878 HRASLS2 HRAS-like suppressor 2 2.45 down NM_016234 ACSL5 acyl-CoA synthetase long-chain family member 5 2.44 down NM_133436 ASNS asparagine synthetase (glutamine-hydrolyzing) 2.41 down NM_000507 FBP1 fructose-1,6-bisphosphatase 1 2.41 down NM_001100878 MROH6 maestro heat-like repeat family member 6 2.38 down NM_170710 WDR17 WD repeat domain 17 2.37 down 0 C4orf46 chromosome 4 open reading frame 46 2.36 down NM_015393 PARM1 prostate androgen-regulated mucin-like protein 1 2.31 down NM_144716 CCDC12 coiled-coil domain containing 12 2.29 down NM_004362 CLGN calmegin 2.29 down NM_002129 HMGB2 high mobility group box 2 2.28 down NM_052969 RPL39L ribosomal protein L39-like 2.28 down BC051726 GLUL glutamate-ammonia ligase 2.27 down NM_182943 PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 2.26 down NM_024629 CENPU centromere protein U 2.25 down NM_004095 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.25 down NM_033429 CALML4 calmodulin-like 4 2.25 down NM_020961 METTL14 methyltransferase like 14 /// methyltransferase like 14 2.22 down NM_032117 MND1 meiotic nuclear divisions 1 homolog 2.22 down NM_032333 FAM213A family with sequence similarity 213, member A 2.22 down NM_024299 PPDPF pancreatic progenitor cell differentiation and proliferation factor 2.20 down 200810 ALG1L ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase-like 2.20 down NM_000712 BLVRA biliverdin reductase A 2.20 down NM_016303 WBP5 WW domain binding protein 5 2.18 down NR_001566 TERC telomerase RNA component 2.16 down --- FBXO25 F-box protein 25 2.16 down NM_000690 ALDH2 aldehyde dehydrogenase 2 family 2.14 down GeneID Gene Symbol Gene Name Fold Change Regulation in LP-1-HIF2A NM_000027 AGA aspartylglucosaminidase 2.14 down NM_138414 CCDC101 coiled-coil domain containing 101 2.14 down NM_021052 HIST1H2AB histone cluster 1, H2ab 2.13 down BC032672 HVCN1 hydrogen voltage-gated channel 1 2.13 down NM_145254 TMEM170A transmembrane protein 170A 2.12 down NM_004794 RAB33A RAB33A, member RAS oncogene family 2.12 down L20860 SEPT5-GP1BB SEPT5-GP1BB readthrough 2.11 down NM_018224 COA1 cytochrome c oxidase assembly factor 1 homolog 2.11 down NM_001085399 RELL1 RELT-like 1 2.11 down NM_147147 BVES blood vessel epicardial substance 2.11 down NM_031903 MRPL32 mitochondrial ribosomal protein L32 2.10 down NM_020192 YAE1D1 Yae1 domain containing 1 2.10 down NM_018569 AP1AR adaptor-related protein complex 1 associated regulatory protein 2.10 down NM_003360 UGT8 UDP glycosyltransferase 8 2.09 down NM_001100626 ERLIN1 ER lipid raft associated 1 2.08 down NM_145740 GSTA1 glutathione S-transferase alpha 1 2.08 down NM_001008393 C4orf46 chromosome 4 open reading frame 46 2.07 down NM_014051 TMEM14A transmembrane protein 14A 2.06 down NM_018010 IFT57 intraflagellar transport 57 homolog 2.06 down NM_021219 JAM2 junctional adhesion molecule 2 2.06