27thAnnual Meeting International Society For Anaesthetic Pharmacology 2018 Syllabus Friday, October 12th, 2018 San Francisco Marriott Marquis 780 Mission St. San Francisco, CA 94103 6737 W. Washington St., Suite 4210 • Milwaukee, WI 53214 (p) 414-755-6296 • (f) 414-276-7704 • www.isaponline.org • [email protected] 27th Annual Meeting • San Francisco, CA Planning Committee Stuart Forman, MD, PhD Mission Statement Massachusetts General Hospital The International Society for Anaesthetic Pharmacology (ISAP) is a nonprofit organization Boston, MA USA with an international membership, which is dedicated to teaching and research about clinical pharmacology in anesthesia, with particular reference to anesthetic drugs. Donald Mathews, MD University of Vermont Accreditation Information College of Medicine Burlington, VT USA Target Audience Practice Gaps: This program is designed for an • Opioid use disorder has been Faculty T. Anthony Anderson, international audience of general identified as a national epidemic. MD, PhD anesthesiologists, pharmacological Anesthesiologists’ perioperative Stanford University School anesthesiologists, technology management may influence long- of Medicine anesthesiologists and specialty term opioid use by patients. Stanford, CA USA physicians. • Reducing the health and societal Michael Avram, PhD Objectives: consequences of opioid use Northwestern University Feinberg School of After attending this program you requires identification of effective Medicine should be able to: alternative approaches to pain Chicago, IL USA management. 1. Understand the role of Jane C. Ballantyne, MD, anesthesiologists in the opioid • Anesthetic and opioid toxicity FRCA epidemic, and how to prevent must be minimized through University of Washington long-term opioid use after improved intra-operative Seattle, WA USA surgery monitoring. Brian T. Bateman, MD, MSc 2. Hear about experimental • Improved peri-operative outcomes Brigham and Women’s Hospital monitoring strategies and their may be achieved through Harvard Medical School potential to improve perioperative discovery of novel general Boston, MA USA care anesthetic drugs. Stuart Forman, MD, PhD 3. Comprehend how artificial • Better pharmacokinetic and Massachusetts General intelligence can improve complex pharmacodynamic modeling Hospital pharmacologic modeling is needed to improve the Boston, MA USA administration of intravenous Tony Gin, FANZA, drugs during general anesthesia. FRCA, MD Chinese University of Hong Kong Hong Kong, China Acknowledgement of Commercial Support Howard B. Gutstein, MD >> Masimo University of Pittsburgh Pittsburgh, PA USA >> Merck Oluwaseun Johnson- Akeju, MD, MMSc Physicians Massachusetts General Hospital Accreditation Statement Harvard Medical School This activity has been planned and implemented in Boston, MA USA accordance with the accreditation requirements and Donald Mathews, MD policies of the Accreditation Council for Continuing University of Vermont Medical Education (ACCME) through the joint College of Medicine providership of Amedco and the International Society for Anaesthetic Burlington, VT USA Pharmacology. Amedco is accredited by the ACCME to provide continuing Gertrude Nieuwenhuijs- medical education for physicians. Moeke, MD Credit Designation Statement University of Groningen AMA University Medical Centre Amedco designates this live activity for a maximum of 6.75 Groningen TM PRA Category 1 Credits . Physicians should claim only the credit Groningen, The commensurate with the extent of their participation in the activity. Netherlands Steven Shafer, MD Stanford University San Francisco, CA USA 2 27th Annual Meeting • San Francisco, CA Disclosure of Conflict of Interest The following table of disclosure information is provided to learners and contains the relevant financial relationships that each individual in a position to control the content disclosed to Amedco. All of these relationships were treated as a conflict of interest, and have been resolved. (C7 SCS 6.1---6.2, 6.5) All individuals in a position to control the content of CE are listed in the program book/agenda. If their name is not listed below, they disclosed that they had no relevant financial relationships. First Name Last Name Company Role Gertrude Nieuwenhuijs-Moeke Baxter/ESA grant 2017 Research Grant Site Principal Investigator Pfizer Research Grant Overall Principal Investigator Lilly Research Grant Site Principal Investigator Baxalta Research Grant Site Principal Investigator Brian Bateman GSK Research Grant Site Principal Investigator Pacira Research Grant Site Principal Investigator Aetion Consultant Mohamed Naguib NeuroTherapia Sarah Eagleman Hospira funded the original study which I retrospectively analyzed here. Other Intelligent Fingerprinting Consultant Cannabix Consultant Marilyn Huestis Frederick Reiders Family Foundation Consultant Evanostics, Inc. Scientific/Medical Advisory Board Member Thermo Fisher Consultant Charles Minto CODAN ARGUS Consultant Acupera Scientific/Medical Advisory Board Member Health Fortis Scientific/Medical Advisory Board Member Peter Szolovits Vanguard Medical Technologies Consultant Health Fidelity Scientific/Medical Advisory Board Member Ross Kennedy GE Healthcare Consultant Ken Johnson Medvis Stock Shareholder Quantium Medical Employee Erik Jensen Quantium Medical Stock Shareholder Joseph Foss NeuroTherapia, Inc. Umberto Melia Quantium Medical Employee Isabel Serra Riera Quantium Medical Employee Umberto Melia Quantium Medical Employee Quantium Medical Employee Erik Jensen Quantium Medical Stock Shareholder Pablo Martinez-Vazquez Quantium Medical, SL. Consultant Masimo Speakers Bureau Donald Mathews Masimo Consultant Continuing Medical Education (CME) Certificate IMPORTANT! To get your certificate, just go to The online certificate site will ISAP.cmecertificateonline.com. be available from October 13th to 1. Go to http://isap.cmecertificateonline.com November 13th. After that date, the site will be removed and certificates 2. Click on the “27th Annual Meeting” link. will no longer be available. If Please print all pages of your certificate for your record. you need a CME certificate, you Questions? Email [email protected] must complete the evaluation and certificate process prior to that date; otherwise you will forfeit your credit for the course. 3 27th Annual Meeting Agenda 07:00 – 08:00 Breakfast & Registration 11:00 – 11:30 Machine Learning for PK/PD Modeling 08:00 – 08:10 Welcome Steven Shafer, MD ISAP President, David Drover, MD 11:30 – 12:45 Lunch, Business Meeting & Poster 08:10 – 08:15 Introduction to the Program Session Stuart Forman, MD, PhD and Donald Mathews, MD 12:45 – 13:45 Moderated Poster Discussion 08:15 – 9:00 Session 1 – Anesthesiologists and 13:45 – 14:45 Session 4 – New Approaches in the Opioid Epidemic Anesthetic Pharmacodynamics and Pharmacokinetics 08:15 – 08:35 Opioid Epidemic Emerged and Strategies to Reverse Recent Trends 13:45 – 14:15 Zebrafish orf High-Throughput Jane C. Ballantyne, MD, FRCA Screening and Pharmacodynamic Profiling of Novel Sedative-Hypnotic 08:35 – 08:55 Opioid-Sparing Anesthetic Compounds Strategies for Enhanced Recovery Stuart Forman, MD, PhD After Surgery T. Anthony Anderson, MD, PhD 14:15 – 14:45 Analgesia Monitors Donald Mathews, MD 09:00 – 09:30 Break 14:45 – 15:15 Break 09:30 – 10:30 Session 2 – Can Perioperative Anesthesia Care Reduce Post- 15:15 – 16:15 Session 5 – New Drug Targets in Operative Opioid Use? Perioperative Medicine 09:30 – 10:00 Molecular Approaches to Reducing 15:15 – 15:45 Potential of Volatile Anesthetics in Opioid Tolerance Organ Transplantation Howard B. Gutstein, MD Gertrude Nieuwenhuijs-Moeke, MD 10:00 – 10:30 The Correlation of Perioperative 15:45 – 16:15 Brain Derived Neurotrophic Factor Anesthesia Approaches with Long- Polymorphisms are Associated with Term Post-Op Opioid Use Chronic Postsurgical Pain, Brian T. Bateman, MD, MSc Suggesting Potential Drug Targets Tony Gin, FANZCA, FRCA, MD 10:30 – 11:30 Session 3 – Improving Anesthesia With Better Monitors 16:15 – 16:55 Keynote Speaker & Lifetime Achievement Award Winner: 10:30 – 11:00 New Uses for EEG Monitoring Michael Avram, PhD Olewaseun Johnson-Akeju, MD, MMSc 16:55 – 17:00 Closing Remarks 17:00 – 18:00 President’s Reception Participant Notification All people with control of the CME content for this Save the Date activity (e.g., faculty/speakers, planners, abstract 28th Annual Meeting reviewers, moderators, authors, co-authors and administrative staff participating) disclosed their Friday, October 18, 2019 financial relationships to Amedco as shown in the list below, which also indicates the resolution, if Orlando, FL applicable. We acknowledge the potential presence of limitations on information, including, but not limited to: data that represents ongoing research; interim analysis; preliminary data; unsupported opinion; or approaches to care that, while supported by some research studies, do not represent the only opinion or approach to care supported by research. 4 Abstract Table of Contents Abstract Abstract Title Author Institution Page # # Activation of mGluR1 Mediates C1q-Dependent Microglial Phagocytosis of 1 Jiang Wu, MD Cleveland Clinic 6-13 Glutamatergic Synapses in Alzheimer's Rodent Models Amyloid Fibrils Induce Dysfunction of Hippocampal Glutamatergic Silent 2 Mark Hocevar, BS Brown University 14-19 Synapses The Nociception Index (qNOX) Correlated with Hypothermia During Pablo Martinez- German Primate 3 20-22 Cardiopulmonary Bypass Vazquez, PhD Center University