Human EBP1 / PA2G4 Protein (His Tag) Catalog Number: 12994-H07E General Information SDS-PAGE: Gene Name Synonym: EBP1; HG4-1; p38-2G4; 38kDa; AA672939; Ebp1; Plfap Protein Construction: A DNA sequence encoding the human PA2G4 (Q9UQ80) (Ser 2-Asp 394) was expressed, with a polyhistide tag at the N-terminus. Source: Human Expression Host: E. coli QC Testing Purity: > 92 % as determined by SDS-PAGE Endotoxin: Protein Description Please contact us for more information. EBP1, also known as PA2G4, is an RNA-binding protein which belongs to Stability: the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre- Samples are stable for up to twelve months from date of receipt at -70 ℃ ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA Predicted N terminal: Met 1 processing. This protein is a transcriptional co-repressor of androgen Molecular Mass: receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. PA2G4 can interact with the The recombinant human PA2G4 consisting of 404 amino acids and has a cytoplasmic domain of the ErbB3 receptor and may contribute to calculated molecular mass of 45.2 kDa. It migrates as an approximately 32 transducing growth regulatory signals. EBP1 has been implicated in growth KDa band in SDS-PAGE under reducing conditions. inhibition and the induction of differentiation of human cancer cells. It seems to be involved in growth regulation. EBP1 also mediates cap- Formulation: independent translation of specific viral IRESs (internal ribosomal entry site). Lyophilized from sterile 20mM Tris, 0.5M NaCl, pH 8.0 References Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in 1.Yoo J Y, et al. (2000) Interaction of the PA2G4 (EBP1) protein with ErbB- the hardcopy of COA. Please contact us for any concerns or special 3 and regulation of this binding by heregulin. Br J Cancer. 82(3):683-90. requirements. 2.Andersen JS, et al. (2002) Directed proteomic analysis of the human nucleolus. Curr Biol. 12(1):1-11. Usage Guide 3.Lehner B, et al. (2004) A protein interaction framework for human mRNA degradation. Genome Res. 14 (7):1315-23. Storage: Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles. Reconstitution: Detailed reconstitution instructions are sent along with the products. Manufactured By Sino Biological Inc., FOR RESEARCH USE ONLY. NOT FOR USE IN HUMANS. Fax :+86-10-51029969 Tel:+86-400-890-9989 http://www.sinobiological.com.