2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P

2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P

2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P. Atkins / L. Jones, Chemical Principles, 4th ed., Freeman (2008) Chapter 19 CHAPTER 19 ORGANIC CHEMISTRY II: POLYMERS AND BIOLOGICAL COMPOUNDS COMMON FUNCTIONAL GROUPS 19.1 Haloalkanes R–X ◈ Nucleophilic substitution reaction (친핵치환반응,親核置換反應) Æ C–X bond is polar Æ Nucleophile replaces X – Ex: OH ion (– charge), H2O (lone pair) Æ Hydrolysis in EtOH(aq) solution −− CH33Br +⎯OH ⎯→+CH OH Br 19.2 Alcohols R–OH ◆ –OH group, –ol Ex: CH3OH: methanol (methyl alcohol) C2H5OH: ethanol (ethyl alcohol) CH3CH2CH2OH: 1-propanol CH3CH(OH)CH3: 2-propanol CH3CH(OH)CH2CH3: Fig. 19.1 The charge distribution in 2-butanol or 2-hydroxybutane an ethanol molecule. Æ Less volatile than alkanes due to hydrogen bonds: Ex: ethanol(l) vs. butane(g) 1 2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P. Atkins / L. Jones, Chemical Principles, 4th ed., Freeman (2008) Chapter 19 ◆ Classification of alcohols according to the number of organic groups attached to the C atom connected to the –OH group: Primary alcohol: RCH2–OH ex: ethanol Secondary alcohol: R2CH–OH ex: 2-butanol Tertiary alcohol: R3C–OH ex: 2-methyl-2-propanol, (CH3)3COH or tertiary-butyl alcohol or tert-butanol ◆ Synthesis of alcohols Æ Nuclear substitution of haloalkanes ▶ Methanol o CO(gg) + 2 H ( ) ⎯catal⎯⎯⎯⎯⎯⎯⎯⎯yst, 250 C,50-100 atm⎯→CH OH(g) 23 synthesis gas Catalyst: mixture of Cu, ZnO, Cr2O3 ▶ Ethanol • Fermentation of carbohydrates. • Hydration of ethane o HP34O, 300C CH22=CH (gg) + H2O( ) ⎯⎯⎯⎯⎯⎯→CH3CH2OH ▶ Ethylene glycol 1,2-ethanediol Diol, two –OH groups Antifreeze component Synthetic fiber 1,2-ethanediol, HOCH2CH2OH 19.3 Ethers R – O – R’ CH32CH −−O CH2CH3, diethyl ether Lower boiling points than alcohols due to lack of hydrogen bonds Fig. 19.2 The lower boiling points of ethers than those of alcohols. 2 2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P. Atkins / L. Jones, Chemical Principles, 4th ed., Freeman (2008) Chapter 19 ▶ Crown ethers : cyclic ethers, Pedersen (1960) 18-crown-6 (1,4,7,10,13,16-hexaoxacyclooctadecane) m–crown–n m: number of atoms in the cycle 18-crown-6 n: number of O atoms Strong binding with metal cations Æ ‘Trojan horse’ for K+ ions Æ soluble in nonpolar sovents 18-crown-6-K Ex. KMnO4(crown ether) ★ Nobel Laureates in Chemistry (1987) "for their development and use of molecules with structure-specific interactions of high selectivity" 出生地: 釜山 父: Norwegian marine engineer Steam-ship to far-east (釜山) Worked at Custom service Worked at Unsan mine Donald J. Cram Jean-Marie Lehn (美,1919-2001) (佛,1939 - ) (平北 雲山金鑛, 미국인 채굴권) Charles J. Pedersen (美,1904-1989) 母: Japanese ◆ Phenols ▶ Phenol, C6H5OH or Carbolic acid Weak acid, but stronger than EtOH Partial oxidation of benzene, Distillation of coal Toxic: lethal dosage,1g WWII Reaction with chlorine in tap water Æ foul smell of C6H5Cl Contamination of Nakdong river in 1991 3 2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P. Atkins / L. Jones, Chemical Principles, 4th ed., Freeman (2008) Chapter 19 ▶ Substituted phenols Essential oils: concentrated, hydrophobic liquids containing volatile aroma compounds from plants. Thymol: Oil of thyme Eugenol: Oil of clove Distillation of herbal plants Used for cosmetics, perfumes – ▶ Resonance structures of phenoxide ion, C6H5O ←⎯→ ←⎯→ ←⎯→ Æ Conjugate base of phenol stabilizes the anion 4 2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P. Atkins / L. Jones, Chemical Principles, 4th ed., Freeman (2008) Chapter 19 – Æ Weaker conjugate base than ethoxide, CH3CH2O Æ Phenol is insoluble in water but soluble in basic solution. ☻ Phenyl methanol, C6H5CH2OH: Benzyl alcohol Æ alcohol, not a phenol 19.4 Aldehydes and Ketones ◆ Aldehyde: –al ▶ Formaldehyde, HCHO methanal 600o C, Ag 2 CH32OH(gg) +⎯O ( ) ⎯⎯⎯⎯→+2 HCHO(g) 2 H2O(g) Destructive effect on bacteria Wood smoke contains HCHO Æ preservation of smoked foods (훈제,燻製) “Formalin” : aqueous solution of HCHO Æ preservation of biological specimens Sick house syndrome (새집증후군,새집症候群) ► Tollens test: ‘Silver mirror’ formation by aldehyde + CH32CH CHO(g) + Ag (in Tollens reagent) ⎯⎯→+CH32CH COOH Ag(s) Tollens reagent: ammoniacal silver nitrate [Ag(NH3)2]NO3 (aq) aldehyde ketone Fig.19.3 The results of Tollens test ▶ Acetaldehyde, CH3CHO ethanal ▶ Aldehydes in essential oils cherry, almond cinnamon (계피,桂皮) vanilla 5 2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P. Atkins / L. Jones, Chemical Principles, 4th ed., Freeman (2008) Chapter 19 ◆ Ketone: –one ▶ Acetone, propanone Good solvent, miscible with water Oxidation of secondary alcohol: CH3CH(OH)CH3(aq) + NaOCl (aq) ⎯⎯→ CH3(CO)CH3 (aq) + NaCl (aq) + H2O (l) ▶ Other ketones: CH3CH2CH2COCH3, 2-pentanone CH3CH2COCH2CH3, 3-pentanone ☻ No reaction with Tollens reagent 19.6 Carboxylic Acids, R–COOH, -oic acid ▶ Carboxyl group, ◆ Formic acid, HCOOH metanoic acid ◆ Acetic acid, CH3COOH ethanoic acid ▶ Oxidation of primary alcohols and aldehydes with a strong oxidizing agent, acidic KMnO4(aq) ▶ Direct oxidation of alkyl groups to carboxyl group RC−−O−R' 19.7 Ester, || , -oate O Æ Product of the reaction between a carboxylic acid and an alcohol Æ Fragrant odors, flavors of fruits ▶ Ethyl acetate, ethyl ethanoate 6 2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P. Atkins / L. Jones, Chemical Principles, 4th ed., Freeman (2008) Chapter 19 ←⎯→ ▶ Benzyl acetate, CH3COOCH2C6H5 Å Oil of jasmine ▶ Tristearin, C57H110O6 Å animal fat Product of the reaction between glycerol and stearic acid, CH3(CH2)16COOH ◆ Condensation reaction Fig. 19.4 Two molecules are linked in a condensation reaction. ★ Trans fats (트랜스지방脂肪) ► Hydrogenation of oils (ester of cis-unsaturated fatty acids) Æ saturated fats with higher m. p. : solid, good for baking and extended shelf-life Æ remaining double bonds converted from cis to trans isomers Å bad for health! ► Transesterification (에스터교환): Switching of the long carboxylic acid chains from one alcohol location to another in a fatty acid by an enzyme. Å acid catalyst Æ double bonds remained with high m.p. but no trans fats 7 2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P. Atkins / L. Jones, Chemical Principles, 4th ed., Freeman (2008) Chapter 19 19.8 Amines, Amino Acids, and Amides | ◆ Amines: R–NH2 (primary), R–NH–R’ (secondary), N (tertiary) / \ ammonia methylamine dimethylamine trimethylamine (primary) (secondary) (tertiary) ► Quaternary ammonium ions: tetrahedral structure + Tetramethylammonium ion, (CH3)4N + Trimethylammonium ion, (CH3)3NH ► Functional group: amino group, –NH2 ► Weakly basic except quaternary ammonium ions ► Foul smell of decaying flesh (along with sulfur compounds) putrescine, NH2(CH2) 4H2 cadaverine, NH2 (CH2) 5NH2 ☻ putrefy : 부패시키다 ☻ cadaver: (해부용)시체(屍體) ◆ Amino Acids NH2 – R – COOH Æ Carboxylic acids containing an amino group (basic) and a carboxyl group (acidic) ▶ Glycine NH2CH2COOH α -amino acid + – “Zwitterion” in aqueous solution (pH=7): H3NCH2CO2 ▶ Alanine CH3CH(NH2)COOH α -amino acid + + – – NH3CH(CH2)COOH Æ NH2CH(CH2)COOH ( NH3CH(CH2) CO2 ) Æ NH2CH(CH2) CO2 acidic solution neutral solution basic solution 8 2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P. Atkins / L. Jones, Chemical Principles, 4th ed., Freeman (2008) Chapter 19 Fig. 19.5 The fractional composition of alanine species as a function of pH. γ β α ▶ GABA (gamma-aminobutyric acid): NH22C H C H2C H2COOH Æ γ -amino acid Æ One of Neurotransmitters (신경전달물질): GABA, Dopamine, Acetylcholine, … ◆ Amide Æ Condensation product of an amine with a carboxylic acid R – (CO) – NHR’ from a primary amine ⎯⎯→ ▶ Mechanism of amide formation (1) An amine (base) accepts a proton from a carboxylic acid, forming quaternary ammonium salt. − + CH33COOH +⎯CH NH2⎯→+CH3CO2CH3NH3 (2) Upon heating to 200oC, Attacking of amine (nucleophile) to the carboxyl carbon Æ Reverse proton transfer ⎯⎯→ ⎯⎯→ ⎯⎯→ 9 2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P. Atkins / L. Jones, Chemical Principles, 4th ed., Freeman (2008) Chapter 19 Caprolactam Nylon-6 Å polyamide Ex. 19.1 Naming compounds with functional groups 3-methyl-2-butanol 4-chloro-2-pentanone diethylpropylamine CH3CH(CH3)CH(OH)CH3 CH3CHClCH2COCH3 (CH3CH2) 2NCH2CH2CH3 THE IMPACT ON MATERIALS ◈ Macromolecules ◆ Polymers: chains or networks of small repeating units forming giant molecules Æ Made by addition reaction and condensation reaction 19.9 Addition Polymerization ◆ Alkenes: Ex: Ethene (monomer, repeating unit) Æ Polyethylene, – (CH2CH2)n – ◆ Substituted ethene monomer, CHX=CH2 X=Cl : CHCl=CH2, vinyl Æ Polyvinyl chloride (PVC), – (CHClCH2)n – X=CH3 : CH3CH=CH2, propene Æ Polypropylene, – (CH(CH3)CH2)n – 10 2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P. Atkins / L. Jones, Chemical Principles, 4th ed., Freeman (2008) Chapter 19 ◆ Radical polymerization ● Initiation: ● Propagations: ● Termination: no more monomers, linkage of two radical chains ★ Problem ! : Random orientation and side-chain growth of polypropylene Æ Poor packing ▶ Ziegler-Natta catalyst : TiCl4 + (CH3CH2)3Al Fig. 19.6 Substituents in a polymer with (a) random and (b) stereoregular (with Z-N catalyst) orientations. 11 2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P. Atkins / L. Jones, Chemical Principles, 4th ed., Freeman (2008) Chapter 19 ★ Nobel Laureate in Chemistry (1963) "for their discoveries in the field of the chemistry and technology of high polymers" Karl Ziegler Giulio Natta (獨,1898-1973) (伊,1903-1979) ● Ziegler: organoaluminum compound catalyst Æ control polymerizations and to obtain molecular chains of the required length ● Natta: Æ a certain Ziegler catalyst leads to a steroregular isotactic polymer Å High-density polymer Å The floating PE, produced from high pressure polymerization. Å The bottom one, produced with a Z-N catalyst. Fig. 19.7 The two samples of polyethylene in a test tube. ▶ Rubber: a polymer of isoprene Isoprene Fig. 19.8 Collecting latex from a rubber tree. ► Natural rubber: obtained from latex from the bark of rubber tree ► Artificial rubber: obtained with Z-N catalyst Æ cis-polyisoprene Naturally occurring material, “gutta-percha” (a plant’s name in Malay, “getah perca”) Æ trans-polyisoprene (golf ball, filling dental canals) 12 2009년도 제2학기 화 학 2 담당교수: 신국조 Textbook: P.

View Full Text

Details

  • File Type
    pdf
  • Upload Time
    -
  • Content Languages
    English
  • Upload User
    Anonymous/Not logged-in
  • File Pages
    24 Page
  • File Size
    -

Download

Channel Download Status
Express Download Enable

Copyright

We respect the copyrights and intellectual property rights of all users. All uploaded documents are either original works of the uploader or authorized works of the rightful owners.

  • Not to be reproduced or distributed without explicit permission.
  • Not used for commercial purposes outside of approved use cases.
  • Not used to infringe on the rights of the original creators.
  • If you believe any content infringes your copyright, please contact us immediately.

Support

For help with questions, suggestions, or problems, please contact us