
US007998.740B2 (12) United States Patent (10) Patent No.: US 7,998,740 B2 Sackstein (45) Date of Patent: Aug. 16, 2011 (54) CYTOKINE INDUCTION OF SELECTIN Butcher, E. C., "Leukocyte-endothelial cell recognition: three (or LGANDS ON CELLS more) steps to specificity and diversity”. Cell, 67: 1033-6 (1991). Cowlandet al., “Isolation of neutrophil precursors from bone marrow (76) Inventor: Robert Sackstein, Sudbury, MA (US) for biochemical and transcriptional analysis”. J. Immunol. Meth. 232:191-200 (1999). (*) Notice: Subject to any disclaimer, the term of this Dereure et al., “Neutrophil-dependent cutaneous side-effects of patent is extended or adjusted under 35 leucocyte colony-stimulating factors: manifestations of a neutrophil U.S.C. 154(b) by 325 days. recovery syndrome'. Brit. J. Dermatol., 150: 1228-30 (2004). Dimitroff et al., “CD44 is a major E-selectin ligand on human (21) Appl. No.: 11/779,650 hematopoietic progenitor cells'. J. Cell. Biol. 153:1277-86 (2001). 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A6 IK38/00 (2006.01) Faulkner et al., “G-CSF serum pharmacokinetics during peripheral CI2N 5/07 (2010.01) blood progenitor cell mobilization: neutrophil count-adjusted dosage CI2N 5/074 (2010.01) might potentially improve mobilization and be more cost-effective'. CI2N 5/078 (2010.01) Bone Marr. Tran. 21:1091-5 (1998). A6 IK3I/35 (2006.01) Fuhlbrigge et al., “Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells', Nature, (52) U.S. Cl. .......... 435/375; 435/377; 514/1.1, 514/7.9; 389:978-81 (1997). 514/451 Fuhlbrigge et al., “Direct real-time observation of E- and P-selectin (58) Field of Classification Search ........... ... None mediated rolling on cutaneous lymphocyte-associated antigen immo See application file for complete search history. bilized on Western blots”, J. Immunol., 168:5645-51 (2002). 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