Switzerland’s biotech hub - a powerful source of innovation AFSSI Connexions, Convention 2019, July 2nd, Lyon Michael Altorfer CEO, Swiss Biotech Association The Swiss biotech industry is a key asset Switzerland is one of the best Local companies hold and most innovative locations leading positions throughout many for biotechnology in Europe and sectors and thus attract capital and the world researchers from all over the world The basis for this success is a In addition to being an attractive close-knit network between place to live for international research and development, driven specialists, Switzerland also offers a by renowned universities, highly modern infrastructure, a specialized SMEs and strong beneficial funding environment multinational corporations and access to a highly-qualified workforce 2 swissbiotech.org A tight cross-functional network Veterinary R&D CMO Bio-IT Analytical Therapeutics Engineering SBA member company activities Cell culture Food & industrial Medtech Biotech consulting Diagnostics Agriculture Chemicals reagents Labware Bio-equipment Non-biotech consulting 3 swissbiotech.org Swiss Biotech: Structural changes offer new investment and partnering opportunities CRO share research risk Biotech companies stay independent: CMOs take over production sites • build their commercial Clinical trials are outsourced organizations and even financed by partners • partner with distributors team up with partners Service providers start that have access to SBA member sharing risks and benefit patients company activities • combine drug and Business models not relying medical device or on product development service provider Investors go it alone, build Some Biotech companies are virtual project teams rather fully financed, eliminating the than companies need for small incremental financing rounds 4 swissbiotech.org Capital investment in Swiss biotech companies 5 Swiss Biotech Day 2019 From 2007 - 2018 Venture Kick invested CHF 3.16 million in 48 Swiss biotech startups. This amount was amplified 159 fold by grants and VC investments. 6 Swiss Biotech Day 2019 High impact patents reflect innovation power 2.0 Switzerland France Denmark Netherlands 1.8 UK Germany 1.6 Canada Australia 1.4 USA 1.2 Japan 1.0 Market coverageMarket 0.8 0.6 China Bubble size represents the number of active patents per country of inventor origin, 0.4 South Korea reporting year 2016 Russia 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 2.2 2.4 2.6 Technology relevance Source: IPI, Swiss Biotech Report 2017 7 swissbiotech.org Major investments in biopharmaceutical production sites Novartis, 2020 Ciba-Geigy, Roche, 2007 EUR 100 million 1996 CHF 400 million MSD (former Werthenstein) 2015, 2008, 2000 MSD (former Werthenstein) 2015, 2008, 2000 Biogen, 2019 CHF 1.5 billion UCB Pharma, 2007 CHF 400 million CSL Behring, 2020 Ferring, 2001 CHF 1 billion CHF 30 million Lonza, 2020 CHF 290 million Serono, 1999 EUR 300 million Cerbios, 2013 SBA, Swiss Biotech Report 2018 Significant and growing export factor 9 swissbiotech.org Swiss Biotech industry in numbers Global talent competitiveness 18 16 8 9 24 17 12 40 7 11 10 31 35 5 1 3 13 25 4 6 2 75 70 65 Score 60 55 50 X Ranking Source: Instead, GTCI Report 2017 11 swissbiotech.org A world-leading Biotech hub • Attractive and reliable framework conditions • Stable political environment • Strong intellectual property protection • Renowned universities • Highly-qualified workforce • Excellent R&D infrastructure • Beneficial funding environment • Superb quality of life 1 Nation - 1 Biotech Cluster 13 swissbiotech.org Swiss Biotech Association The central resource for the Swiss biotech industry Members of the Swiss Biotech Association (255) 3M • Abologix • AC Bioscience • AC Immune • Activen • ADC Therapeutics • Addex Therapeutics • Adolf Kühner • Agidens • Alphastrat • AlveoliX • Amal Therapeutics • Anaveon • Anergis • Anjarium Biosciences • Asceneuron • Assystem Care • Aurealis Pharma • Axon Lab • B3C Group • Baccinex • Bachem • Baliopharm • Basilea Pharmaceutica • BC Platforms • Becton Dickinson • Bench • Bideco • Bio Innovations • BioConcept • Bioengineering • Biogen • BioLingus • Biomapas • Biopôle • Bio-Rad • Biosynth • Bio- Technopark Schlieren-Zürich • BioVersys • blsc • Bucher Biotec • Büchi • BÜHLMANN • Cabinet Privé de Conseils • Calypso Biotech • Canlion • Carbogen Amcis • CarthaGenetics • C-CIT Sensors • CDR-Life • CEBIS International • Celerion • Cell Medica • Cellestia Biotech • Cerbios-Pharma • certus molecular diagnostics • Chemgineering Technology • Cilatus Biopharma Consulting • CimArk • CIS Pharma • Clinipace • Consultants in Science • Coulter & Partners • CRB • Creoptix • CSL Behring • CTC Clinical Trial Consulting • Culture Collection of Switzerland • Curatis • Debiopharm International • DXC RT • EffRx Pharmaceuticals • Elanix Biotechnologies • Elthera • Eurofins Medical Device Testing • EVA • Evitria • ExcellGene • ExpertInova • Finox Biotech • Future Health Pharma • Gain Therapeutics • GBiotech • GE Healthcare • Geistlich Pharma • Gene Signal • Genedata • GeNeuro • Genkyotex • Glenmark Pharmaceuticals • GMT Fine Chemicals • Healthcare Impact Foundation • Hemex • Heptares Therapeutics • HGF • Homburger • Humabs BioMed • IBR • ICON Clinical Research • Idorsia Pharmaceuticals • IE Life Science Engineering • Incyte Biosciences International • Inflamalps • Infors • InnoMedica • Inofea • Inositec • InSphero • Integra Biosciences • InterAx Biotech • Janssen-Cilag • Jenal & Partners Biosafety Consulting • Jung & Partners • KPMG • Labatec Pharma • Laves- Arzneimittel • LeadXpro • LimmaTech Biologics • Lipidon • Lonza • Loroch • LubioScience • Lunaphore Technologies • LYO-X • Malcisbo • Marsa Corporate Finance • Maxia Strategies • MD Biosciences • Med Discovery • Mediatum • Memo Therapeutics • Merck & Cie • MetrioPharm • Micro-Sphere • Microsynth • Molecular Partners • Morgan Sindall • Mymetics • NBE-Therapeutics • NDA • Neurimmune • Novartis Pharma • NovImmune • Numab • ObsEva • Oculis • OLS • Omya • Onelife • P & G MedChem • Pall • PAREXEL • Phargentis • Philip Morris International • Philochem • Phoenixus Pharmaceuticals • PIQUR • PolyGene • Polyneuron • Polyphor • Preclin Biosystems • PreComb Therapeutics • Promega • ProteoMediX • PSI CRO • Quotient Suisse • Recordati • Redbiotec • RegenLab • regulanet • ReseaChem • Roche Glycart • SAKK • Santhera • Sartorius • Schmidt Versicherungs Treuhand • Seagen International • Securecell • Selexis • Servier • SFL Pharma • SGS M-Scan • Shimadzu • SimplicityBio • Socorex • SOPHiA GENETICS • SpacePharma • Dr. Rudolf K.Sprüngli • Strekin • SunRegen Healthcare • Swiss Institute for Regenerative Medicine • Swissfillon • Switzerland Global Enterprise • SynDermix • Syngenta • Synlab • Synple Chem • T3 Pharma • Talentmark • Target BioScience • tepthera • the RSA Group • Therachon • Thermo Fisher Life Technologies • Thermo Fisher Scientific Prionics • Tigermed • Tillotts Pharma • tiventa • TJM Conseils • Tolerys • TOLREMO therapeutics • Toolpoint for Lab Science • Topadur • Triplan Ingenieur • UCB • Unitectra • ValuationLab • Vaxxilon • Venture Valuation • Versameb • Versantis • Virometix • Voisin Consulting Life Sciences • MSD Werthenstein BioPharma • Wyss Zurich 15 swissbiotech.org Our mission Developing favorable and competitive framework conditions Attracting talent, know-how and financial resources to drive innovation and growth 16 swissbiotech.org Swiss Biotech Association Improving framework conditions Clinical Technology transfer developments Seed / venture Academia – Industry Industry – Hospital Taxation capital collaborations collaborations 17 swissbiotech.org Swiss Biotech Association Business solutions Co-promotions SBA Academy Discounted business Promotion support Discounted access Seminars offerings (e.g. Biotech directory, Speaker Workshops pension fund) jobs, clinical pipeline opportunities 18 swissbiotech.org Our mission Developing favorable and competitive framework conditions Attracting talent, know-how and financial resources to drive Promoting the innovation and growth accomplishments of the Swiss biotech industry Fostering networking through strategic, national and international partnerships 19 swissbiotech.org The Swiss Biotech Directory Finding the right partner – Switzerland's most comprehensive database www.swissbiotech.org/companies/ 20 swissbiotech.org Celebrating and honoring major achievements The Swiss Biotech Association has launched Swiss Biotech Success Stories to celebrate those who have made significant contributions to the industry Dedicated to scientists, pioneers, entrepreneurs, innovators and supporters who led the way, opened the horizon and prepared the ground for lasting achievements Swiss Biotech Success Stories accentuate past industry highlights and act as motivator for future achievements Award winner 2019 Launched the Swiss Biotech Success Stories Award The first awards went to: • Biogen • Okairos • Roche Glycart • Selexis • Vifor Fresenius Renal Medical Care Pharma General Assembly, 23 swissbiotech.org May 7, 2019 National biotech convention: Swiss Biotech Day in Basel > 850 participants (plus 30%) 1st year of success story award 38% participants from abroad (plus 5%) 47 new members of the 42 exhibitors (plus 55%) Swiss Biotech Association (plus 25%) 906 organizations in 2019 Swiss Biotech Swiss Biotech Directory (plus 35%) > 30 co-promotion partner Report (plus 200%) 34 swissbiotech.org .