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Consumer provide readers with the tools necessary to deal with real-world analysis issues, thereby Waste increasing their efficiency, productivity and value to their employer. www.chromatographyonline.com 331 COVER STORY July | 2017 334 A Review of MS-Based Approachess to Analyze Erectile Dysfunction Drugs in Volume 30 Number 7 Botanical Dietary Supplements: Are Those Products All Natural? Lukas Vaclavik and Katerina Mastovska This review paper highlights current approaches and recent developmentss in PDE-5 inhibitor MS-based analyses,s, including those that aim at screening and structural elucidation of novel designer analogues. Features 346 The Role of Surface Coverage and Orthogonality Metrics in Two-Dimensional Chromatography Michelle Camenzuli This review discusses the role of orthogonality metrics and surface coverage metrics and their relationship to selectivity and peak capacity in two-dimensional chromatography. 372 Food Analysis Focus: Measuring Mycotoxins Rudolf Krska from the University of Natural Resources and Life Sciences in Vienna, Austria, discusses the latest analytical techniques and challenges facing analysts involved in the evolving field of mycotoxin analysis. Columns 352 LC TROUBLESHOOTING Column Care for the Long Haul—Considerations for Column