Every one of us. 2018/19 Impact Report Every one of us has been touched by a devastating illness. It might begin unexpectedly. Out of nowhere. News you never wanted to hear. An event you never wanted to happen. Shaking your world to its foundation. Making you wonder what’s to come. And what does come is something extraordinary. A life restored. A family made whole again. A discovery years in the making that few imagined possible. A person who sees what can be achieved and is devoted to helping us see it through. These are our stories. And every one of them is a testament to your generosity. Baby Arjan weighed only 1.5 pounds when he was born. His father, Navendu, holds him in Sunnybrook’s NICU during the earliest, and scariest, days. 2018/19 I mpact Report Leadership message P4 Your impact A Promise P45 of the Board of Extraordinary Directors P46 P6 Governing A Life Restored, Council P48 a Family Rose Awards Made Whole P49 P16 Sunnybrook Next A Vision of Generation What Can be P50 Community Achieved events P24 P51 Kilgour A Belief in a Legacy members/ Discovery Years Legacy gifts in the Making P52 P36 Donor lists Today, Arjan (L), pictured P53 with brother Angad (R), is a happy one-year-old, who his mother Kriti says completes their family. 2 3 Thank you Every day, across Sunnybrook’s The leading-edge technologies of our campuses, our scientists and clinicians Cancer Ablation Therapy Program are are inventing new ways to stop disease designed for personalized and precise and save lives, to make the impossible treatments, ofering patients better possible regardless of the odds, thanks results and faster recoveries. As the to your support. only Canadian member of the interna- tional consortium developing the Our place at the forefront of medical MR-Linac, our teams have advanced innovation was showcased last fall complex research so our partners can at the Focused Ultrasound: A New extract the full beneft of this leading- Frontier for Brain Therapy symposium. edge tool. In August Sunnybrook Sunnybrook partnered with the treated the frst patient in Canada esteemed Gairdner Foundation to using this technology made possible show the world how we are developing with donor support. this game-changing technology to advance patient care. Philanthropy touches every part of the hospital, and we pledge to hold Thanks to early and sustained philan- ourselves to the highest level of thropic support, Sunnybrook now has accountability in return for your trust the largest focused ultrasound research in making gifts to support innovation, program in the world. From the stage, equipment, capital projects and more. our scientists shared world frst after We encourage you to review our world frst in their use of targeted beams fnancial overview on page 44 or our full of sound to challenge the most urgent audited fnancial statements online at brain diseases of our time. sunnybrook.ca/foundation/statements. Today there is new promise for patients When you read the stories in this report, and their families, with ongoing focused and additional stories online, you will ultrasound trials for Alzheimer’s, ALS, understand the enduring impact of your brain cancer, depression and OCD; and gifts on the lives of our patients and their new trials underway for Parkinson’s, loved ones. Together, we are challenging MS tremor, essential tremor and, in the impossible on all fronts, resolute partnership with SickKids, for a devas- in our purpose to invent the future of tating form of paediatric brain cancer. health care. Fred Waks Dr. Jon S. Dellandrea, C.M. CHAIR, SUNNYBROOK FOUNDATION PRESIDENT & CEO BOARD OF DIRECTORS SUNNYBROOK FOUNDATION 4 5 2018/19 I mpact Report A Promise of the On the same day that Paul was diagnosed with a dangerous form of brain cancer, Sunnybrook approved a groundbreaking Paul HudspithExtraordinary new clinical trial that could one day change the course of this devastating disease. Paul took it as a sign. 6 7 2018/19 I mpact Report It all started with a dull headache for Paul Hudspith, an engineer, cellist and Paul soon learned that on the very Paul was invited to participate in a decent quality of life. Secondly, same day as his diagnosis, Sunny- Phase 2 of this clinical trial, which I hope participating helps give me married father of two. brook scientists received approval is the frst time in the world that a better prognosis.” for a new clinical trial that could be focused ultrasound will be paired When that headache Innovative research at Sunnybrook a game-changer. He and his wife with chemotherapy to target glio- is only possible with donor support. suddenly turned took this as a sign that it was meant blastoma. Sunnybrook scientists Thanks to you, our team is exploring to be. recently completed and published into unbearable this groundbreaking technology results of the Phase 1 trial, which Sunnybrook researchers, led by in patients with Alzheimer’s, ALS, pain and vomiting, established the safety of the proce- Dr. Nir Lipsman, director of the depression, OCD, Parkinson’s dure – also a world frst. he was rushed to Harquail Centre for Neuromodula- and more. tion, are exploring the use of The prospect of participating in Sunnybrook’s Now a “pioneer” in one of our lead- focused ultrasound to deliver this high-tech trial was daunting at ing clinical trials, Paul is grateful to chemotherapy to glioblastoma frst, but Paul, as an engineer, was Emergency all who contribute toward better tumours. By using a helmet-like fascinated. “Involvement in the trial treatment options for patients Department. device that can convert electrical means two things to me,” he says. like him. energy to sound energy, we can now “Firstly, I hope my involvement can “focus” waves of ultrasound over advance this exciting form of treat- “I’ve found this to be a gift that specifc regions in the brain guided ment so others can survive glioblas- comes with this disease: the grati- by MRI imaging. Where those waves toma and other brain ailments with tude for everything that is good in converge, Sunnybrook scientists life and gratitude toward those who have invented a unique method of support me every day.” temporarily and reversibly opening the blood-brain barrier, a protective layer that prevents harmful – as well as helpful – substances from entering the brain. With this barrier no longer an obstacle, the hope is that focused ultrasound can deliver chemotherapy directly to the tumour, where it can do the most good. We asked Paul to play his cello for us. He graciously complied and played us Bach: Cello Suite No. 1, This device Emergency scans revealed that A biopsy revealed that Paul had amongst other great pieces. is opening the a brain tumour was bleeding into a form of brain cancer called blood-brain Paul’s brain. glioblastoma, the same cancer barrier for that claimed the life of Canadian the first time. “I was told surgery was required to musician and icon, Gord Downie, save my life,” he says. “I eventually in 2017. This is the most common learned that if I hadn’t gone to the and aggressive of malignant brain hospital when I did –- and Sunny tumours, striking about 1,000 brook in particular because not Canadians every year. all hospitals are able to perform the brain surgery I needed – I likely In the days following this devasta- would not have survived.” ting news, Paul was overcome by “fear and shock.” He turned to yoga Paul’s surgery was successful and for positive energy and became his tumour was removed. But then focused on fnding the best possible things took a turn for the worse. treatment for his disease, which included intensive radiation and chemotherapy at Sunnybrook ’s Odette Cancer Centre. 8 9 Your generosity has made Sunnybrook a global leader Clinical in focused ultrasound (FUS). Thanks to you, we research are launching clinical trials that will test this extraordinary technology as a treatment for the most devastating disorders of our time. On behalf of the millions who stand to beneft, thank you. Alzheimer’s disease Brain tumours World’s frst clinical trial using First in the world to open the focused ultrasound (FUS) to open blood-brain barrier to deliver the blood-brain barrier in people chemotherapy directly to the brain. with Alzheimer’s disease. Parkinson’s disease Amyotrophic Lateral First Canadian trial and part of Sclerosis (ALS) the frst international trial testing First in the world to open the use of FUS to treat to treat blood-brain barrier using FUS Parkinson’s disease. in people with ALS. Obsessive-compulsive disorder Essential tremor First North American trial testing First Canadian trial and only Canadian high-intensity FUS in patients with site in the frst international, random- treatment-resistant OCD. ized trial for FUS in essential tremor. Head and neck cancer Major depression World’s frst clinical trial to test First North American trial testing use of MRI-guided FUS in treating high-intensity FUS in patients with this cancer. treatment-resistant major depression. Uterine fbroids Rectal cancer World’s frst dual-site FUS World’s frst clinical trial on use surgery centre to test clinical of high-intensity FUS for treatment ablation of uterine fbroids of recurrent rectal cancer. with high-intensity FUS. Bone metastases From start to finish: Paul and Francine’s pup Paul’s world-first procedure. Beau enjoying a day of First paediatric patient in North belly rubs, treats and walks America treated with FUS at in the family ravine. Sunnybrook for a bone tumour. 10 11 2018/19 I mpact Report Little device, Pioneering big impact heart procedure Supported entirely by donors, saves high-risk Sunnybrook’s Schulich Heart Program launched Canada’s patients frst TAVI program in 2009, offering transcatheter aortic valve implantation to patients who could not withstand open-heart surgery.