1642 Corticosteroids Ointment; Colistin and Neomycin Sulfates and Hydrocortisone Preparations Ph. Bur. 8: (Methylprednisolone), A white or almost white, Acetate Otic Suspension; Hydrocortisone Acetate Cream; ·········································· crystalline powder. It shows polymorphism. Practically Hydrocortisone Acetate Injectable Suspension; Hydrocortisone Proprietary Preparations (details are given in Volume B) insoluble in water; sparingly soluble in alcohol; slightly Acetate Lotion; Hydrocortisone Acetate Ointment; Hydrocorti­ SingleRingredient Preparations. Arg.: Alrex; Lopred; Lotemax; soluble in acetone and in dichloromethane. Store at a sone Acetate Ophthalmic Ointment; Hydrocortisone Acetate Lotesoft; Talof; Austria: Lotemax; Braz. : Alrex; Loteprol; temperature of 2 degrees to 8 degrees. Protect from light. Ophthalmic Suspension; Hydrocortisone and Acetic Acid Otic Canad.: Alrex; Lotemax; Chile: Oftol; China: Lotemax Solution; Hydrocortisone Butyrate Cream; Hydrocortisone (il\1i3:iil'); USP 36: (Methylprednisolone), A white to practically white, Ger.: Lotemax; Gr.: Lotemax; Hong Kong: Alrex; Lotemax; Cream; Hydrocortisone Gel; Hydrocortisone Injectable Suspen­ odourless, crystalline powder. Practically insoluble in water; India: Loteflam; Lotepred; Irl. : Lotemax; Israel: Lotemax; Ital.: sion; Hydrocortisone Lotion; Hydrocortisone Oinnnent; Hydro­ soluble 1 in 100 of alcohol, and in l in 800 of chloroform Lotemax; Mex. : Loterex; Lotesoft; Pol. : Lotemax; Singapore: cortisone Rectal Suspension; Hydrocortisone Sodium Phosphate and of ether; slightly soluble in acetone; sparingly soluble in Lotemax; Thai.: Lotemax; Turk. : Lotemax; UK: Lotemax; USA: Injection; Hydrocortisone Sodium Succinate for Injection; Alrex; Lotemax; Venez. : Lotesoft. dioxan and in methyl alcohol. Store in airtight containers. Hydrocortisone Tablets; Hydrocortisone Valerate Cream; Hydro� Protect from light. cortisone Valerate Ointment; Neomycin and Polymyxin B Multi-ingredient Preparations. Arg. : Loternicin; Zylet; Braz.: Sulfates and Hydrocortisone Acetate Cream; Neomycin and Zylet; Israel: Zylet; Mex. : Zyleth; Singapore: Zylet; Thai.: Zylet; Polymyxin B Sulfates and Hydrocortisone Acetate Ophthalmic USA: Zylet. Suspension; Neomycin and Polymyxin B Sulfates and Hydro� cortisone Ophthalmic Suspension; Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Solution; Neomycin and Polymyxin B Sulfates and Hydrocortisone Otic Suspension; Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Acetate Ophthalmic Ointment; Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Ointment; Neomycin and Polymyxin B Sulfates, Bacitracin Zinc, and Hydrocortisone Ophthalmic Ointment; Neomycin and Polymyxin B Sulfates, Bacitracin, and Hydrocortisone Acetate Ointment; Neomycin and Polymyxin B Sulfates, Bacitracin, and Hydrocortisone Acetate Ophthalmic Ointment; Neomycin and Polymyxin B Sulfates, Gramicidin, and Hydrocortisone Acetate Cream; Neomycin Sulfate and Hydrocortisone Acetate Cream; Neomycin Sulfate and Hydrocortisone Acetate Lotion; Neomycin Mazipredone is a corticosteroid used topically for Sulfate and Hydrocortisone Acetate Ointment; Neomycin Sulfate glucocorticoid activity (p. 1597. I). It is used as the Ph. Bur. 8: (Methylprednisolone Acetate). A white or and Hydrocortisone Acetate Ophthalmic Ointment; Neomycin hydrochloride with miconazole in the treatment of fungal almost white, crystalline powder. Practically insoluble in Sulfate and Hydrocortisone Acetate Ophthalmic Suspension; infections of the skin. water; sparingly soluble in alcohol and in acetone. Protect Neomycin Sulfate and Hydrocortisone Cream; Neomycin Sulfate When applied topically, particularly to large areas, when and Hydrocortisone Ointment; Neomycin Sulfate and Hydro� from light. the skin is broken, or under occlusive dressings, cortisone Otic Suspension; Oxytetracycline Hydrochloride and corticosteroids may be absorbed in sufficient amounts to USP 36: (Methylprednisolone Acetate). A white or Hydrocortisone Acetate Ophthalmic Suspension; Oxytetra· cause systemic effects (p. I6I5.3). The effects of topical practically white, odourless, crystalline powder. Soluble 1 cycline Hydrochloride and Hydrocortisone Ointment; Polymyxin in 1500 of water, I in 400 of alcohol, 1 in 250 of chloroform, B Sulfate and Hydrocortisone Otic Solution. corticosteroids on the skin are described on p. 1617.3. For recommendations concerning the correct use of corticoster­ and I in 1500 of ether; sparingly soluble in acetone and in oids on the skin, see p. 1599.2. methyl alcohol; soluble in dioxan. Store in airtight containers at a temperature of 25 degrees, excursions Preparations permitted between 15 degrees and 30 degrees. Protect from . ...................... ....... ..... .............. ........... .......... .......... light. ProprietaryPreparations (details are given in Volume B) Single-ingredient Preparations. Rus.: Depersolon (L(enep3onoH). Methylprednisolone Hydrogen Succinate Multi-ingredient Preparations. Hung. : Mycosolon; Pol.: Mycoso· (BANM, r/NNM) 1/9 Ion; Rus.: Mycosolon (MnK03onoH); Ukr.: Mycosolon (MHK030JlOH)t. Pharmacopoeias. In US for veterinary use only. M;'!predf'lisciria: Me!)rednlsohe; . rvu.-:p�e(fnis<)nUrn; 1o!l­ NSC527579; . USP 36: (Isoflupredone Acetate). Protect from light. Methylpredni;;one; Sdt-435s;.MenpeAHvl3oH, · 1 7a,21. :Dihydroxy- 16�'rnethyfpregna: l,4-dien<O: 3,11 ,20- Profile tridn<O. Isoflupredone acetate is a corticosteroid that has been used for its topical glucocorticoid activity (p. 1597.1) in allergic rhinitis. Isoflupredone is also employed in veterinary medicine. ProprietaryPreparations (details are given in Volume B) USP 36: (Meprednisone). Store in airtight containers at a temperature not exceeding 40 degrees. Protect from light. Israel: Multi-ingredient Preparations. Proaft. Ph. Bur. 8: (Methylprednisolone Hydrogen Succinate). A Profile white or almost white, hygroscopic powder. Practically insoluble in water; slightly soluble in dehydrated alcohol Meprednisone is a corticosteroid with mainly glucocorticoid Loteprednol Etabonate (BANM, USAN, r/NNM) ® and in acetone; dissolves in dilute solutions of alkali activity (p. 1597. 1), It has been given orally as either the hydroxides. Store in airtight containers. Protect from light. CD[)D,S604; Eta'bopcto de tot�pred�oi;HGP-1; Loteprednol, free alcohol or the acetate and by injection as the sodium USP 36: (Methylprednisolone Hen1isuccinate). A white or rti.!bon�te de; Lqtepredno( etcbqnato de; Loreprednol �thy! hemisuccinate. C:qrbonate; .· Lotepredno!i Eta bonas; · P:51i04; 11or.;r�peAHOJ1a nearly white, odourless or nearly odourless, hygroscopic solid. Very slightly soluble in water; freely soluble in alcohol; soluble in acetone. Store in airtight containers. ProprietaryPreparations (details are given in Volume B) Single-ingredient Preparations. Arg.: Cortipyren B; Deltisona B; Methylprednisolone Sodium Succinate Latisona Bt; Prednisonal; Prenolone; Rupesona B; Mex. : Lee­ (BANM, r/NNM) 1/9 tan. Methylprednisolone (BAN, r/NN) ® Meilprednizolon; ethylpred · :tyl nisolon; 6a�Me�h:flpred\1iso­ Profile lone; Me\�ylpresJnfsdon<O;f\1et!1y! prednis()lo�um; Metiipred.­ nisolona; MetHprednizolon; Metilp edrilzol6nas; .lv1etyfpred­ Loteprednol etabonate is a corticosteroid used for its � n is olon; MeJYyli pr.edr<rs olon1: NSC·l99S7; glucocorticoid activity (p. 1597.1) in the topical manage­ . ment of inflammatory and allergic disorders of the eye. It is MerMnnp��M3dno;;.· 1.1j3;l7o,2l-T rihyd roxy76CI·r!1ethylptegna� ,4-cllene:3,20- usually used as eye drops containing 0.2 or 0.5%. · 1 Prolonged application to the eye of preparations dione. containing corticosteroids has caused raised intra ·ocular CnH,o05cd74.5 pressure and reduced visual function. (AS 8.3:43·2. AT( -001M 01; HO.?AB04 USP 36: (Methylprednisolone Sodium Succinate). A white References. or nearly white, odourless, hygroscopic, amorphous solid. 1. Noble S, Goa KL. Loteprednol etabonate: clinical potential in the ATC VeT --.-- QD07A401;QD 10M02; OH02A B(M. Soluble I in 1.5 of water and 1 in I2 of alcohol; very slightly management of ocular inflammation. BioDrugs 1998; 10: 329-39. UNit '-'X4W1ZR7023. soluble in acetone; insoluble in chloroform and in ether. 2. Pavesio CE, DeCory HH. Treatment of ocular inflammatory conditions with loteprednol eta bonate. Br J Ophthalmo/ 2008; 92: 455-9. Pharmacopoeias. In Bur. (see p. vii), Jpn, and US. Store in airtight containers. Protect from light. All cross·references refer to entries in Volume A .