Table 2 HIF-1 target genes Unigene ID Hyp/Norm Name Name Hs.296323 0.50 SGK serum/glucocorticoid regulated kinase Hs.1048 0.53 KITLG KIT ligand Hs.1048 0.53 KITLG KIT ligand Hs.171723 0.55 TAF9L TAF9-like RNA polymerase II, TATA box binding protein Hs.374524 0.55 DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 Hs.21486 0.56 STAT1 signal transducer and activator of transcription 1, 91kDa Hs.390504 0.57 SOS2 son of sevenless homolog 2 (Drosophila) Hs.2227 0.57 CEBPG CCAAT/enhancer binding protein (C/EBP), gamma Hs.464526 0.58 ABHD3 abhydrolase domain containing 3 Hs.107056 0.60 CED-6 PTB domain adaptor protein CED-6 Hs.417157 0.61 MGC14376 hypothetical protein MGC14376 Hs.201939 0.61 ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a isoform 2 Hs.7879 0.61 IFRD1 interferon-related developmental regulator 1 Hs.25204 0.61 CHST12 carbohydrate (chondroitin 4) sulfotransferase 12 Hs.58617 0.62 ROCK2 Rho-associated, coiled-coil containing protein kinase 2 Hs.477132 0.62 COPA coatomer protein complex, subunit alpha Hs.389893 0.62 DLG1 discs, large homolog 1 (Drosophila) Hs.439052 0.63 SPIN spindlin Hs.334534 0.63 GNS glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) Hs.459631 0.63 Homo sapiens cDNA FLJ12835 fis, clone NT2RP2003165. Hs.336425 0.63 Homo sapiens mRNA; cDNA DKFZp313P052 Hs.17969 0.64 KIAA0663 KIAA0663 gene product Hs.28578 0.65 MBNL1 muscleblind-like (Drosophila) Hs.55220 0.65 BAG2 BCL2-associated athanogene 2 Hs.143840 0.65 KIAA0852 KIAA0852 protein Hs.432996 0.66 FLJ12448 hypothetical protein FLJ12448 Hs.159118 0.66 AMD1 adenosylmethionine decarboxylase 1 Hs.443409 0.67 ODC1 ornithine decarboxylase 1 Hs.153648 79.51 PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF) Hs.9613 13.36 ANGPTL4 angiopoietin-like 4 Hs.433611 13.29 PDK1 pyruvate dehydrogenase kinase, isoenzyme 1 Hs.511915 11.12 ENO2 enolase 2, (gamma, neuronal) Hs.441047 10.84 ADM adrenomedullin Hs.283844 10.16 BA108L7.2 similar to rat tricarboxylate carrier-like protein Hs.171825 9.91 BHLHB2 basic helix-loop-helix domain containing, class B, 2 Hs.318567 9.21 NDRG1 N-myc downstream regulated gene 1 Hs.198278 8.36 PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Hs.437647 6.94 FLJ10415 hypothetical protein FLJ10415 Hs.27744 6.65 RAB3A RAB3A, member RAS oncogene family Hs.79428 6.29 BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 Hs.467262 5.74 PTRF polymerase I and transcript release factor Hs.10862 5.47 AK3 adenylate kinase 3 Hs.123159 5.41 SPAG4 sperm associated antigen 4 Hs.155247 5.14 ALDOC aldolase C, fructose-bisphosphate Hs.79428 5.12 BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 Hs.171825 4.88 BHLHB2 basic helix-loop-helix domain containing, class B, 2 Hs.132955 4.51 BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like Hs.7089 4.37 INSIG2 insulin induced gene 2 Hs.10949 4.34 ERO1L ERO1-like (S. cerevisiae) Hs.10862 4.28 AK3 adenylate kinase 3 Hs.96028 4.23 FOXD1 forkhead box D1 Hs.462911 4.21 NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) Hs.443452 4.12 PMX1 paired mesoderm homeo box 1 Hs.195471 4.12 PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Hs.61762 3.80 HIG2 hypoxia-inducible protein 2 Hs.462911 3.72 NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) Hs.73793 3.47 VEGF vascular endothelial growth factor Hs.104800 3.43 FLJ10134 hypothetical protein FLJ10134 Hs.118630 3.28 MXI1 MAX interacting protein 1 Hs.32352 3.23 DKFZp434K1210 hypothetical protein DKFZp434K1210 Hs.289007 3.21 FLJ10803 hypothetical protein FLJ10803 Hs.37054 3.14 EFNA3 ephrin-A3 Hs.1869 3.04 PGM1 phosphoglucomutase 1 Hs.73793 3.00 VEGF vascular endothelial growth factor Hs.5243 2.99 E2IG5 growth and transformation-dependent protein Hs.132955 2.99 BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like Hs.111244 2.86 RTP801 HIF-1 responsive RTP801 Hs.511986 2.85 GBE1 glucan (1,4-alpha-), branching enzyme 1 Hs.303090 2.85 PPP1R3C protein phosphatase 1, regulatory (inhibitor) subunit 3C Hs.321707 2.80 JMJD1 jumonji domain containing 1 Hs.274317 2.78 DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 Hs.274485 2.78 HLA-C major histocompatibility complex, class I, C Hs.444594 2.74 LOC283849 hypothetical protein LOC283849 Hs.27410 2.71 PBF papillomavirus regulatory factor PRF-1 Hs.498489 2.70 PFKP phosphofructokinase, platelet Hs.76768 2.65 P4HA1 procollagen-proline, 2-oxoglutarate 4-dioxygenase) Hs.32393 2.62 DARS aspartyl-tRNA synthetase Hs.198281 2.62 PKM2 pyruvate kinase, muscle Hs.25590 2.61 STC1 stanniocalcin 1 Hs.363315 2.61 B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 Hs.371366 2.57 APS adaptor protein with pleckstrin homology and src homology 2 Hs.515218 2.57 7h3 hypothetical protein FLJ13511 Hs.63304 2.56 PME-1 protein phosphatase methylesterase-1 Hs.73793 2.56 VEGF vascular endothelial growth factor Hs.386225 2.54 GYS1 glycogen synthase 1 (muscle) Hs.406266 2.53 HK2 hexokinase 2 Hs.315379 2.51 WSB1 SOCS box-containing WD protein SWiP-1 Hs.110571 2.49 GADD45B growth arrest and DNA-damage-inducible, beta Hs.104772 2.47 P4HA2 procollagen-proline, 2-oxoglutarate 4-dioxygenase) Hs.25590 2.46 STC1 stanniocalcin 1 Hs.110571 2.43 GADD45B growth arrest and DNA-damage-inducible, beta Hs.318127 2.42 FLJ10201 hypothetical protein FLJ10201 Hs.45743 2.35 ADORA2B adenosine A2b receptor Hs.238679 2.35 RRAGD Ras-related GTP binding D Hs.155223 2.34 STC2 stanniocalcin 2 Hs.109590 2.33 GENX-3414 genethonin 1 Hs.448341 2.32 ZNF292 zinc finger protein 292 Hs.143323 2.31 PLU-1 putative DNA/chromatin binding motif Hs.315379 2.30 WSB1 SOCS box-containing WD protein SWiP-1 Hs.3416 2.28 ADFP adipose differentiation-related protein Hs.150555 2.27 HSU79274 protein predicted by clone 23733 Hs.4082 2.26 LGALS8 lectin, galactoside-binding, soluble, 8 (galectin 8) Hs.315379 2.25 WSB1 SOCS box-containing WD protein SWiP-1 Hs.78771 2.25 PGK1 phosphoglycerate kinase 1 Hs.78771 2.25 PGK1 phosphoglycerate kinase 1 Hs.226007 2.25 RDH11 retinol dehydrogenase 11 (all-trans and 9-cis) Hs.213289 2.25 LDLR low density lipoprotein receptor (familial hypercholesterolemia) Hs.154396 2.24 CT120 membrane protein expressed in epithelial-like lung adenocarcinoma Hs.25590 2.23 STC1 stanniocalcin 1 Hs.77961 2.16 HLA-B major histocompatibility complex, class I, B Hs.28988 2.16 GLRX glutaredoxin (thioltransferase) Hs.2795 2.14 LDHA lactate dehydrogenase A Hs.388170 2.12 FLJ10534 hypothetical protein FLJ10534 Hs.512813 2.11 SAP30 sin3-associated polypeptide, 30kDa Hs.7277 2.11 PEX3 peroxisomal biogenesis factor 3 Hs.352733 2.09 PAM peptidylglycine alpha-amidating monooxygenase Hs.179791 2.09 RAB20 RAB20, member RAS oncogene family Hs.78781 2.08 VEGFB vascular endothelial growth factor B Hs.143323 2.08 PLU-1 putative DNA/chromatin binding motif Hs.7277 2.03 PEX3 peroxisomal biogenesis factor 3 Hs.443906 2.02 EGLN3 egl nine homolog 3 (C. elegans) Hs.118893 2.01 D2S448 Melanoma associated gene Hs.147747 2.01 HOXA4 homeo box A4 Hs.274485 2.00 HLA-C major histocompatibility complex, class I, C Hs.72222 1.98 FER1L4 fer-1-like 4 (C. elegans) Hs.508741 1.97 C5orf13 chromosome 5 open reading frame 13 Hs.256526 1.97 NARF nuclear prelamin A recognition factor Hs.102929 1.95 AF3P21 SH3 protein interacting with Nck, 90 kDa Hs.75694 1.95 MPI mannose phosphate isomerase Hs.441069 1.95 MIZ1 Msx-interacting-zinc finger Hs.51 1.94 PIGA phosphatidylinositol glycan, class A Hs.35380 1.93 BBX bobby sox homolog (Drosophila) Hs.78979 1.93 GLG1 golgi apparatus protein 1 Hs.75199 1.93 PPP2R5B protein phosphatase 2, regulatory subunit B (B56), beta isoform Hs.512813 1.93 SAP30 sin3-associated polypeptide, 30kDa Hs.9291 1.92 7h3 hypothetical protein FLJ13511 Hs.274579 1.92 CNNM1 cyclin M1 Hs.83469 1.92 NFE2L1 nuclear factor (erythroid-derived 2)-like 1 Hs.211600 1.91 TNFAIP3 tumor necrosis factor, alpha-induced protein 3 Hs.315379 1.91 WSB1 SOCS box-containing WD protein SWiP-1 Hs.55565 1.90 ANKRD3 ankyrin repeat domain 3 Hs.13321 1.90 RLF rearranged L-myc fusion sequence Hs.130316 1.90 MGC10772 hypothetical protein MGC10772 Hs.77266 1.89 QSCN6 quiescin Q6 Hs.155223 1.89 STC2 stanniocalcin 2 Hs.324844 1.89 IMAGE3455200 hypothetical protein IMAGE3455200 Hs.20644 1.89 BCKDK branched chain alpha-ketoacid dehydrogenase kinase Hs.512152 1.86 HLA-G HLA-G histocompatibility antigen, class I, G Hs.77768 1.86 DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 Hs.101174 1.85 MAPT microtubule-associated protein tau Hs.308026 1.85 HLA-DRB3 major histocompatibility complex, class II, DR beta 3 Hs.150136 1.85 MAPK7 mitogen-activated protein kinase 7 Hs.77961 1.84 HLA-B major histocompatibility complex, class I, B Hs.83469 1.84 NFE2L1 nuclear factor (erythroid-derived 2)-like 1 Hs.130946 1.84 EGLN1 egl nine homolog 1 (C. elegans) Hs.274485 1.83 HLA-C major histocompatibility complex, class I, C Hs.512152 1.82 HLA-G HLA-G histocompatibility antigen, class I, G Hs.211773 1.81 CHES1 checkpoint suppressor 1 Hs.352733 1.81 PAM peptidylglycine alpha-amidating monooxygenase Hs.179312 1.80 SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa Hs.142076 1.80 LOC91373 hypothetical protein LOC91373 Hs.9071 1.80 PGRMC2 progesterone receptor membrane component 2 Hs.356537 1.80 DAAM1 dishevelled associated activator of morphogenesis 1 Hs.448341 1.79 ZNF292 zinc finger protein 292 Hs.110488 1.79 CHSY1 carbohydrate (chondroitin) synthase 1 Hs.279843 1.79 MLH3 mutL homolog 3 (E.