! !" # " ! $ % &" (+178 3!4 # 5 6) 01 # ./ ),*- (+ '" () *) : " #$ " # %&'() *+,- .) # ! " 5563 % % 7 123 5563 % ( %& %& '()% *+ ,-. /) 0 , (. 123 ,4 ( . ( 3 '. 0 ) '()% *+ ,-. " 0 % 7 *+ , (.9 '&8 !-. ,-. " 0 % 7 *+ , (.9 '&8 !-. 5563 % % 7 123 5563 % !:3( '. %& %& '()% *+ ,-. /) 0 , (. 123 ,4 (# 3 '. 0 ) '()% *+ ?@ " /) 0 , (. '()% *+ ,-. ;0 ) *0 %& :<= !, ; e-mail: [email protected] /01 *+ " 7+ ,# . - . %#5 , 6 .3 ,4 2# "- :*) ) :> #) .-# *,# *) 9# :;) " # " #$ %&'() < * ) * =$ *&'() 9# .-# , 6 H4 , 6 2# "- * H EFG ") /) BCD# ./A ?@ =$ *&'() G :* + .-# /4 #@# . "' # ) ) H, 9' # H*JIJ 9J H*C- # ;L) %#2 %&'() 9# H"J D * . 4 *&'() # " #$ *' ) K " # *' ) .* ,4 # HB- 7@ * M 9# < . / >#7 . , 6 .3,4 R#B &) , , 6 S(- # R#B &) H" #$ " # %&'() Q . /4 /N-# OJ-P . / >#7 *C- , 6 # R#B&) " #$ %&'() T >#7 4 # . / >#7 # H, 9' # *JIJ 9J V * HR#B&) #7+# .U) %&'() :.* ? .-# / U) # "$ * + >#7 *J,#) # W # #7+# %&'() Q Downloaded from ijem.sbmu.ac.ir at 2:56 +0330 on Tuesday September 28th 2021 1 H4 *4# .6 .3 ,4 .N) 2 #" ) *J,#) # Q =$ .) R*&'() " #$ RB - * H*) 9# [ = R* + ", @ Y' * #Z' . S=# X " %#2 .-# 7' X) %&'() <? # R# RQ " # *(*4 0*4H EFG 0 23 0 0 7 /0 D C /0 :! *A 4B M / /R : 5 1 Q M / J/L :NOP /I QM /L/J : 5 /I J Z <G "& , ) 0 /G , ) O+ Y 5 . G S Y * ZM 0 LR <G %L 3 R /TH \ /0 C) U C) /G 'T) '( 0 <OS C /0 ^ /*+ H%) !H0 /G , ) U0 SU WG 0 . )0' V %I <N EFG i ./G ,0 ' ^ /*+ H T3 (IDF ) "/0 '**H 0 G I" ,.; U <G 3 ' _ U SU WG 0 * L N J <G /0 0 O: I T3 ;8" .) O: /0 0 Y ` ' R #J# * #/ V0 J <G IDF U 3 a:b C) 0 O: /0 !H0 0 Y i -International Diabetes Mellitus , c# z3 % D z3 z3) Vo0 d <G G RM 3 J <4%0 /TH 0 !H0 \) z3 !, B * .0 , ) \(.3 ( z3 . ) U0 %L/# !,B * S ;& <; 0 {0 ! * H* H3 I S ;& E6P \ <; 0 '0/G `30 0 {0 ! * H* H3 \) z3 d '()% @ T ! 0 !0 !V 8 '0 H* .0 0 0 {0 !, B * \) z3 !\ HT G T F @ I /G , !, B * 0 . ) , /50F MESHii 0 ! * /0 G <e ! 0 ?/G Y /0 / !d T0 ) ,YG (OR) "" /2 z3 0 'QQQ 1QQ7 !QQQ\ H( gQQQf (ADA i ) (U z3 <f3 ! 0 (AND) "" H* z3 ;' H ;. U Y !GhI \QQQQ 0 {0 !, B * ./G , ) ,YG ' !d \ H( gf 0 jN @V 9 !0 i N lactobacillus probiotics probiotic :\QQQ) z3 `30 @*S l6: #kR. 3 bifidobacteria bifidobacterium lactobacilli & 3 0 /0 !H0 <; lactic acid bacteria fermented milk streptococcus !QQQ"QQQ4 QQQn m 3QQ0 L./G QQQI4 diabetic diabetes \) D z3 0 {0 !,B * P 0 'IA T3 0 4 A ;)0' ' !H07 insulin blood glucose fasting blood sugar glycemia '0n <T3 d , 4 & ,YG , impaired fasting impaired glucose tolerance resistance S 0% 0 '.o0 'OG Y p , 0 {0 !,B * glucose homeostasis glucose M. )' r6 ;G I ! 17 q% \ H 0 . 0 body weight changes body weight \) z3 0 m30 Y p <HN SID iii i3+Ob ,- % 'GI h5 'G0 *I 23 ab C /0 !H0 S ;& <; !g 0 D C /0 !,B * /I4 d !0 ' N @V 9 J.) d , '0( 0QQ*4H QQ 0 0 7 /0 S ;& ' 0. _ ).0 , ) d ; W*G0h !g 0 `30 % *(*4 %4 S ;& <; 0 m30 p3 0 F0 . ) ,YG Ho3 /G 0 Y0 T F s @ I /G ' N k Z. ,H "iv " %I '3+Ob !,- h5 H3 c k L. )0' Y ; ' . 4 g1N ! (3 h5 < *N , ) /0 !H0 !h0 C) 0 3 0 0;0 Downloaded from ijem.sbmu.ac.ir at 2:56 +0330 on Tuesday September 28th 2021 :T F |S T !H0 / /H T F t&; @I d x:3 7 h5 g1N _; 0 ! 'G0 QQQ /OG QQQm30 V5 0 S 3 & ! G ` '3h5 '* b 0 . ) @ *S T F jN @ISG ! T F : ) g1N ;) 0 m30 p 0 F0 ' N ' Q QQT F 'TF5 T F !QQ T F i , 3 /0 !H0 S ;& !uS) <; ! , . T F G T F ! ) .H 'G0 J # .'fo.3 T F ! T F \(3 ` \ h5 ' Vd;G ! 0 ' T F G U ;3 ) , S U h5 ro ISG !d ,6 ` 0 m30 (RCTv) *S p x5I ' N i3+Ob !, - 0 T 0 T F ,H 'G0 C /0 !H0 S ;& !uS) 0 /: Chochrane central Pubmed Scopus '0 / 6 . ) T F 0 ' , 3 U w O+ x:3 T F H3 !UvH . 4 & J # ii - Medical Subject Headings iii - Scientific Information Database iv - EndNote v - Randomized Clinical Trial i -American Diabetes Association cZ 5. .* 4 3 : 1 $!% " &'( )* +, -./0 !"# + 9 8!#6, 6 7 0 S 'B ' 3 'G0 0 '3T F 0 /I4 P % , ) x:3 h5 \ 0 '3T F 0 , ) d vi'-.U x ) h5 % '*- \ 0 h5 ;3 z33 h \H63 + ; x:3 7 !I 'G0 . ) jN @ T F 0 'GI /GN h0 S ;& ~ +) ` 0 ;G ;& /Tj 'G0 _; 0 T F !uS) U ' N T F 0 S ('; : 0 :+ S ( G4 4S ;) 7 0 '3 N S ;& ii'* S ;& (FPGi) ) S ;& U '3T F 0 I4 & 'G0 (HbA1c iv ) *(*4 0*4H (OGTT iii ) QQQ+G , ) 'G0 S ;& !u S) 0 ` 30, p x5I .(IRv) '; /5 S .0 _; 0 h5 \ ' @T F T0 I Jadad W5 , ) ' h5 /Y Vd;G ! QQT F /Y 0 h5 3 M ) ,YG :' T F 0 '* h G W5 . ) |S ISG , B * z3 ,YG 0 !d : ) ,YG h5 0 ' ! 0 POS ;+ 'G0 • ) /I 5 MRM , ) ,YG "'If3" T F U k T F 0 \ 0 5 cL x:3 7 h5 g1N }/G !I 'G0 \ 0 5 0 . ) , ) ,YG "G" T F U k g1N (In Vitro) '-.U @ ,YG 'B }/G J k J (3 \ 0 5 ' N h5 0 . ) }/G , ) ~ I % T3 T F U k k x:3 7 z F ; S ;& @ I ,0 /:e r 0 0 WG 0 ' `30 , p 'G0 \ 0 - 5 c ;8" . ) , YP 'Y; r 0 ` # k M 'G0 \ 0 ' N 5 ` . ) g1N T F ! E6P \ Ej3 P #J ' N 5 ;8" C /0 0 O: !H < G 0 % Ij ` "G " "'If3" , ) ,YG G4 4S !H U ` 0 zG; P , ) , # # '*- 'GI 7 '0 0 5 0 '3h5 . )' \ ` # Downloaded from ijem.sbmu.ac.ir at 2:56 +0330 on Tuesday September 28th 2021 0 5 ? ) |S T F % 0 /Y 0 h5 ;+ 0 0 .0 ! 4€ ~ 0 ` 0 ;G 'G0 50 ) jN T F 0 , ) r6 h0 ## . ) g1N T F 0 S S ;& !I . ) g1N T F jN T F 0 5 # ;3 x:3 ' T F c 0 i4 ISG ' !d ,0 c k L ; T F \h 0 5 ;I , /I4 & 'G0 _ zNP 3G \(. , ) ~ S ;& @ I 5 : ) ) 14 0 "Hf3 . ) 'G0 U \ ,0 #Z /0 5 Z 0 , (3 ,0 . h5 : ) I4 !'49 ` 0 T F - g1N # c R #c #R h \H63 + p 5 ! 0 'V9 :GO <; ,4 &I T F #L W5 '; 5 0 , 'G0 ; ! 5 S ;& 0 x:3 @I #M ZJ vii ` 5 0 , z 0 '3T F 0 , (3 x:3 7 @I z W5 ,H ,YG G 0 S ! 0 /0 0 `30 p 'G0 !G ! `€ 5 ` #M0 , ZJ 0 I /G ! 0 ,: ' H % i -Fasting Plasma Glucose ii - General Plasma Glucose iii -Oral Glucose Tolerance Test vi -In vitro iv -Glycated Hemoglobin vii - Jadad Scale v-Insulin Resistance , cc Z ' 5 # \) 5 M CHd 0;0 '*- 7 '0 0 - 5 ;8" T F , '&0 ' 'G0 ' N 5 Z kZ . 0 'GI /I h5 8*I \() . ) ISG ! 5 ` Z#ZZi N 5 /G ~ ) @ I /Y % . ' . , ) \N ;+ 0 `30 , U Ri @< z33 0 , %40 ' N ' h5 0 @ 5 0 U i 0 , ) ,YG `30 ./G , U T F 0 , ) , VU @,4 H . ) - , ) /I T F T3 ( T3=L#) Pubmed , ) /I T F T3 ( T3=R) 'G COb !,- ( T3= ) Scopus , ) /I T F T3 ( T3=) Cochrane , ) /I T F T3 ( T3= ) SID , ) /I T F T3 'G0 T F \ ( T3=MRM) EndNote ! (3 T F T3 ( T3= Z) ( T3=cRc) , ) |S T F T3 'G0 ! 0 , '&0 T F T3 ( T3= #L) x:3 7 T F ( T3=R##) ( T3= ) -, ;U T F ( T3= Z) ! ) Q T F ( T3= c ) ') %4 T F ( T3= #) 'TF5 T F ( T3= J ) ! , . T F - ( T3= #J) ! T F Downloaded from ijem.sbmu.ac.ir at 2:56 +0330 on Tuesday September 28th 2021 ( T3= ) '0 7 !,4 ! '; 0 T F ( T3= ) (pilot) '.U T F ( T3= R) U \ 'G0 T0 , ) |S h5 \ 0 , ) T F \ ( T3=#) '*:& h5 ! (3 w !N T F ( T3=cL) p 'G0 / ( T3=Z) ;S ! 0 /0 'G0 0 T F ( T3= ) - !0 ' \ 0 x:3 ' N h5 ( T3= ) - !0 ' \ 0 x:3 ' h5 ( T3=) ;I /G Jadad W5 'I 0 '3T F ( T3= ) 0 , ) d (in vitro) '4 VU x6 '3T F ( T3= ) 0 S x: 7 S ;& !I 0 '3T F ( T3=) 0 S 7 0 '3 N 'G0 0 ' N T F ( T3=L) 0 S `3:;G `30, 'G0 0 IP '3T F , ) ' T F S ;& uS) 7 0 ` 0 ;G !u S) 'G0 0 '3T F ( T3=M) ( T3= ) 0 S ( T3= ) 0 S C /0 'G0 0 '3T F , ) ' N ' T F I SG !d w H k \() cR 5. .* 4 3 : 1 $!% " &'( )* +, -./0 !"# + 9 8!#6, 6 7 , ) ' T F fo. k < % T3 uS) * ,4 ,4 % !uS) !0 4 G /(c) <; W5 C •; T3 , ; P 5 VU P 5 VU `HO4 - () *S T3 d Jadad !B *S *S 4 ;;/) (8 <G) 0 /: <; 0 /: , H *S T F ) 'I † <; (Pro) (/Y § k - - J/J /TH) S FPG <… Y L !N <… C=R Y Z# 'U # = 'HP+ „ ;& V %I <… !!0 Pro=R ( ) '; 0 ) (H (S !N Lactobacillus 'If3 (xG (J ) ¶ acidophilus, L.