TGF-beta receptor 2 Recombinant Protein Cat. No.: 91-819 TGF-beta receptor 2 Recombinant Protein Specifications SPECIES: Human SOURCE SPECIES: Human Cells SEQUENCE: Thr23-Asp159 FUSION TAG: C-Fc tag TESTED APPLICATIONS: APPLICATIONS: This recombinant protein can be used for biological assays. For research use only. PREDICTED MOLECULAR 42.6 kD WEIGHT: Properties Greater than 95% as determined by reducing SDS-PAGE. PURITY: Endotoxin level less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test. PHYSICAL STATE: Lyophilized Lyophilized from a 0.2 um filtered solution of 20mM PB,150mM NaCl,pH7.2. It is not BUFFER: recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. September 30, 2021 1 https://www.prosci-inc.com/tgf-beta-receptor-2-recombinant-protein-91-819.html Lyophilized protein should be stored at -20˚C, though stable at room temperature for 3 weeks. STORAGE CONDITIONS: Reconstituted protein solution can be stored at 4-7˚C for 2-7 days. Aliquots of reconstituted samples are stable at -20˚C for 3 months. Additional Info OFFICIAL SYMBOL: TGFBR2 TGF-beta receptor type-2, TGF-beta type II receptor, TGFBR2, Transforming growth factor- ALTERNATE NAMES: beta receptor type II ACCESSION NO.: P37173 GENE ID: 7048 Background and References TGFBR2 is a single-pass type I membrane protein and contains one protein kinase domain. TGFBR2 exsits as a heterodimeric complex with another receptor protein and binds TGF-beta. Signals triggered through the TGF-beta receptor complex prompt various responses by the cell. One such response is to inhibit cell growth and division. Based on BACKGROUND: this action, the TGF-beta receptor type 2 is sometimes called a tumor suppressor. Defects in TGFBR2 have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome and the development of various types of tumors. ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. September 30, 2021 2 https://www.prosci-inc.com/tgf-beta-receptor-2-recombinant-protein-91-819.html.