Supplementary Table I Genes regulated by myc/ras transformation signal Probe set Gene symbol gene + dox/ - E2 - dox/ - E2 - dox/ +E2 100011_at Klf3 Kruppel-like factor 3 (basic) 308 120 270 100013_at 2010008K16Rik RIKEN cDNA 2010008K16 gene 127 215 859 100016_at Mmp11 matrix metalloproteinase 11 187 71 150 100019_at Cspg2 chondroitin sulfate proteoglycan 2 1148 342 669 100023_at Mybl2 myeloblastosis oncogene-like 2 13 105 12 100030_at Upp uridine phosphorylase 18 39 110 100033_at Msh2 mutS homolog 2 (E. coli) 120 246 92 100037_at 2310005B10Rik RIKEN cDNA 2310005B10 gene 178 351 188 100039_at Tmem4 transmembrane protein 4 316 135 274 100040_at Mrpl17 mitochondrial ribosomal protein L17 88 142 89 100041_at 3010027G13Rik RIKEN cDNA 3010027G13 gene 818 1430 1033 methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate 100046_at Mthfd2 cyclohydrolase 213 720 376 100064_f_at Gja1 gap junction membrane channel protein alpha 1 143 574 92 100066_at Gart phosphoribosylglycinamide formyltransferase 133 385 180 100071_at Mup2 major urinary protein 2 26 74 30 100081_at Stip1 stress-induced phosphoprotein 1 148 341 163 100089_at Ppic peptidylprolyl isomerase C 358 214 181 100091_at Ugalt2 UDP-galactose translocator 2 1456 896 1530 100095_at Scarb1 scavenger receptor class B, member 1 638 1044 570 100113_s_at Kifap3 kinesin-associated protein 3 482 168 311 100116_at 2810417H13Rik RIKEN cDNA 2810417H13 gene 134 261 53 100120_at Nid1 nidogen 1 81 47 54 100125_at Pa2g4 proliferation-associated 2G4, 38kD 62 286 44 100128_at Cdc2a cell division cycle 2 homolog A (S. pombe) 459 1382 247 100133_at Fyn Fyn proto-oncogene 168 44 82 100144_at Ncl nucleolin 1283 3452 1215 100151_at Tde1 tumor differentially expressed 1 620 351 620 100153_at Ncam1 neural cell adhesion molecule 1 302 144 234 100155_at Ddr1 discoidin domain receptor family, member 1 304 117 310 100156_at Mcmd5 mini chromosome maintenance deficient 5 (S. cerevisiae) 347 717 153 100272_at Smcy selected mouse cDNA on the Y 11 21 45 100279_at Siat5 sialyltransferase 5 125 75 76 100286_at Mst1 macrophage stimulating 1 (hepatocyte growth factor-like) 51 18 17 100290_f_at 6230416J20Rik RIKEN cDNA 6230416J20 gene 52 96 31 100291_at Cbl Casitas B-lineage lymphoma 31 56 43 100297_at 1600024A01Rik RIKEN cDNA 1600024A01 gene 120 73 90 100302_at Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F (avian) 21 53 26 100308_at Col8a1 procollagen, type VIII, alpha 1 931 262 949 100309_at Met met proto-oncogene 76 21 35 100342_i_at Tuba1 tubulin, alpha 1 5791 1931 4214 100353_g_at Hspa4 heat shock protein 4 435 703 466 100371_at Hnrpa1 heterogeneous nuclear ribonucleoprotein A1 31 64 28 100380_at H3f3a H3 histone, family 3A 1121 654 756 100412_g_at Aebp1 AE binding protein 1 2071 898 1427 100420_at Flg filaggrin 44 15 25 100429_at Ppox protoporphyrinogen oxidase 112 59 112 100435_at Edg2 endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2 847 309 391 100453_at Camk2b calcium/calmodulin-dependent protein kinase II, beta 5 44 24 100465_i_at --- Mus musculus, clone IMAGE:3371572, mRNA 280 161 143 100482_at --- Mus musculus, clone IMAGE:5355325, mRNA 259 450 366 100483_at Ifnar1 interferon (alpha and beta) receptor 1 108 30 79 100486_at Ezh1 enhancer of zeste homolog 1 (Drosophila) 70 31 90 100488_at Gba acid beta glucosidase 659 309 845 100512_at Uchl5 ubiquitin carboxyl-terminal esterase L5 30 93 26 100539_at Bach-pending brain acyl-CoA hydrolase 208 353 201 100547_at 4921506I22Rik RIKEN cDNA 4921506I22 gene 237 99 99 100553_at Trim27 tripartite motif protein 27 226 606 230 100554_at Pdlim1 PDZ and LIM domain 1 (elfin) 72 221 188 100562_at Rangnrf-pending RAN guanine nucleotide release factor 107 280 73 100565_at Gnpi glucosamine-6-phosphate deaminase 140 67 101 100573_f_at Gpi1 glucose phosphate isomerase 1 191 329 221 100575_at Ard1 N-acetyltransferase ARD1 homolog (S. cerevisiae) 82 228 82 100577_at Snrpd1 small nuclear ribonucleoprotein D1 40 65 41 100578_at Impdh2 inosine 5'-phosphate dehydrogenase 2 502 1415 371 100580_at Clta clathrin, light polypeptide (Lca) 23 49 62 100593_at Tnnt2 troponin T2, cardiac 14 53 21 100596_at Selenbp1 selenium binding protein 1 8 53 36 100600_at Cd24a CD24a antigen 122 35 42 100603_at Dncic2 dynein, cytoplasmic, intermediate chain 2 118 56 89 100606_at Prnp prion protein 2702 1282 2648 100607_at Pld3 phospholipase D3 293 101 285 100636_at Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 95 225 161 100697_at Pax3 paired box gene 3 11 21 11 100756_r_at Tyms-ps thymidylate synthase, pseudogene 86 214 148 100828_at Myla myosin light chain, alkali, cardiac atria 49 19 49 100877_at 1810058I24Rik RIKEN cDNA 1810058I24 gene 1074 585 744 100885_at Nek2 NIMA (never in mitosis gene a)-related expressed kinase 2 114 303 108 100886_f_at Mrpl45 mitochondrial ribosomal protein L45 154 296 180 100887_at 2810489L22Rik RIKEN cDNA 2810489L22 gene 44 80 41 100890_at 2600017H24Rik RIKEN cDNA 2600017H24 gene 90 214 106 100906_at Itgb7 integrin beta 7 178 468 627 100915_at Myh9 myosin heavy chain IX 2523 1461 2139 100923_at Myo10 myosin X 1122 293 776 100928_at Fbln2 fibulin 2 2508 1269 1442 100931_at Arsa arylsulfatase A 504 236 409 100953_at Timeless timeless homolog (Drosophila) 89 169 87 100955_at 2700084L22Rik RIKEN cDNA 2700084L22 gene 22 59 13 100974_at 1210002E11Rik RIKEN cDNA 1210002E11 gene 131 231 129 100977_at D530020C15Rik RIKEN cDNA D530020C15 gene 118 222 137 100983_at Prep prolyl endopeptidase 101 214 114 100986_at Fhl2 four and a half LIM domains 2 669 329 491 100988_at Bcl2l11 BCL2-like 11 (apoptosis facilitator) 321 164 211 100992_at Edr1 early development regulator 1 (homolog of polyhomeotic 1) 113 66 79 101015_s_at Ifnar2 interferon (alpha and beta) receptor 2 47 22 64 101027_s_at Pttg1 pituitary tumor-transforming 1 277 635 195 101039_at Col4a2 procollagen, type IV, alpha 2 1474 775 1095 101051_at S100a3 S100 calcium binding protein A3 66 109 80 101055_at Ppgb protective protein for beta-galactosidase 2084 1118 1996 101059_at Ndn necdin 336 171 193 101065_at Pcna proliferating cell nuclear antigen 291 826 204 101070_at Mkrn1 makorin, ring finger protein, 1 104 64 81 101073_at Lrp1 low density lipoprotein receptor-related protein 1 2161 979 2043 101083_s_at D17H6S56E-2 DNA segment, Chr 17, human D6S56E 2 266 578 183 101086_f_at Cnbp cellular nucleic acid binding protein 869 1657 882 101093_at Col4a1 procollagen, type IV, alpha 1 1164 552 787 101094_at Hig1-pending hypoxia induced gene 1 33 91 53 101099_at Nsg1 neuron specific gene family member 1 91 27 32 101105_at Bcrp1-pending breakpoint cluster region protein 1 1018 2228 1276 101108_at Nasp nuclear autoantigenic sperm protein (histone-binding) 41 73 34 101123_at Itm2b integral membrane protein 2B 1707 741 2165 101130_at Col1a2 procollagen, type I, alpha 2 7639 4621 8498 101180_at Atm ataxia telangiectasia mutated homolog (human) 87 176 194 101214_f_at Gapd glyceraldehyde-3-phosphate dehydrogenase 2161 3891 2701 101254_at Ran RAN, member RAS oncogene family 3763 6742 3389 101341_at H2-M9 histocompatibility 2, M region locus 9 21 44 50 101356_at Tk2 thymidine kinase 2, mitochondrial 102 56 76 101367_at Dctn1 dynactin 1 525 313 428 101384_at 2210008A03Rik RIKEN cDNA 2210008A03 gene 49 15 16 101385_at Mbd3 methyl-CpG binding domain protein 3 586 1060 533 101407_at Frda Friedreich ataxia 42 93 58 101414_at Lmnb2 lamin B2 67 118 52 101429_at Ddit3 DNA-damage inducible transcript 3 213 111 501 101433_at H2ls histocompatibility-2 complex class 1-like sequence 83 32 66 101435_at Akap2 A kinase (PRKA) anchor protein 2 96 41 68 101450_at Csf1 colony stimulating factor 1 (macrophage) 1316 609 1499 101451_at Peg3 paternally expressed 3 208 72 88 101453_at Mia melanoma inhibitory activity 18 35 29 101455_at Umps uridine monophosphate synthetase 40 91 16 101457_at Jak2 Janus kinase 2 54 30 66 101465_at Stat1 signal transducer and activator of transcription 1 103 57 679 101472_s_at Pklr pyruvate kinase liver and red blood cell 10 42 12 101484_at Nbr1 next to the Brca1 830 466 782 101485_at 2400003O03Rik RIKEN cDNA 2400003O03 gene 757 1231 722 101486_at Psmb10 proteasome (prosome, macropain) subunit, beta type 10 187 611 1047 101487_f_at Ly6e lymphocyte antigen 6 complex, locus E 3872 6614 10091 101489_at Amd1 S-adenosylmethionine decarboxylase 1 482 812 413 101494_at Afp alpha fetoprotein 19 45 40 101503_at Dpysl3 dihydropyrimidinase-like 3 119 55 61 101507_at 3110001I17Rik RIKEN cDNA 3110001I17 gene 31 7 43 101509_at Vbp1 von Hippel-Lindau binding protein 1 374 648 307 101515_at Acox1 acyl-Coenzyme A oxidase 1, palmitoyl 114 60 108 101516_at Cd59a CD59a antigen 88 31 88 101521_at Birc5 baculoviral IAP repeat-containing 5 89 232 55 101527_at Tcea1 transcription elongation factor A (SII) 1 509 829 521 101551_s_at Tes testis derived transcript 225 129 224 101554_at Nfkbia nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha 401 257 249 101560_at Emb embigin 2077 437 732 101576_f_at Spi1-2 serine protease inhibitor 1-2 80 43 68 101588_at Slc16a1 solute carrier family 16 (monocarboxylic acid transporters), member 1 28 64 34 101590_at Lamp2 lysosomal membrane glycoprotein 2 1238 506 1222 101623_at Slc16a8 solute carrier family 16 (monocarboxylic acid transporters), member 8 19 53 35 101624_at Kcns1 K+ voltage-gated channel, subfamily S, 1 38 22 39 101632_at Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a 42 14 64 101634_at Npm1 nucleophosmin 1 2077 3442 1622 101650_at Pcdha6 protocadherin alpha 6 83 20 52 101764_at