ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Voliume 22 Contents for November 1982 No. 5 Mechanisms of Action: Physiological Effects Mechanism of Action of Dnacin B1, a New Benzoquinoid Antibiotic with Antitumor Properties. SEIICHI TANIDA,* TORU HASEGAWA, AND MASAHIKO YONEDA .... .................. 7735-742 Synergism Between Aminoglycosides and Cephalosporins with An- tipseudomonal Activity: Interaction Index and Killing Curve Method. HANS 0. HALLANDER,* KATHRINE DORNBUSCH, LENA GEZELIUS, KARIN JACOBSON, AND INGA KARLSSON .... 7743-752 Diffusion of j-Lactam Antibiotics Through Liposome Membranes Containing Purified Porins. YORIKo KOBAYASHI, IKUKO TAKAHASHI, AND TALJI NAKAE* ..... ...................... 7775-780 Influence of Subinhibitory Concentrations of Penicillin, Cephalothin, and Clindamycin on Staphylococcus aureus Growth in Human Phagocytic Cells. GREG R. ELLIOTT,* PHILLIP K. PETERSON, HENRI A. VERBRUGH, MARK R. FREIBERG, JQHN R. HOIDAL, AND PAUL G. QUIE ....................................... 781-784 Antibacterial Action of Gramicidin S and Tyrocidines in Relation to Active Transport, In Vitro Transcription, and Spore Out- growth. W. DANDERS, M. A. MARAHIEL,* M. KRAUSE, N. Kosui, T. KATO, N. IZUMIYA, AND H. KLEINKAUF ... ...... 7785-790 Transport of the Lipophilic Analog Minocycline Differs from That of Tetracycline in Susceptible and Resistant Escherichia coli Strains. LAURA M. MCMURRY,* JOANNE C. CULLINANE, AND STUART B. LEVY ......... ............................... 7791-799 Effect of 2-Alkynoic Acids on In Vitro Growth of Bacterial and Mammalian Cells. WATTANA KONTHIKAMEE, JOHN R. GILBERTSON,* HERMAN LANGKAMP, AND HERMAN GERSHON 8305-809 7-Hydroxytropolone: an Inhibitor of Aminoglycoside-2"-O-Adenylyl- transferase. N. E. ALLEN,* W. E. ALBORN, JR., J. N. HOBBS, JR., AND H. A. KIRST ....... ............................. 8324-831 Mechanisms of Resistance Candida albicans Resistance to 5-Fluorocytosine: Frequency of Partially Resistant Strains Among Clinical Isolates. KEITH S. DEFEVER, WILLIAM L. WHELAN, ALVIN L. ROGERS, EVERETT S. BENEKE, JAMES M. VESELENAK, AND DAVID R. SOLL* .... 8310-815 Selection for Mercurial Resistance in Hospital Settings. FORBES D. PORTER, SIMON SILVER,* CATHERINE ONG, AND HIDEOMI NAKAHARA .............................................. B52-858 Monitoring of Plasmid-Encoded, Trimethoprim-Resistant Dihydrofo- late Reductase Genes: Detection of a New Resistant En- zyme. MARY E. FLING, LESLIE WALTON, AND LYNN P. ELWELL* ................................................ B82-888 Nonenzymatic Chloramphenicol Resistance Determinants Specified by Plasmids R26 and R55-1 in Escherichia coli K-12 Do Not Confer High-Level Resistance to Fluorinated Analogs. C. J. DORMAN AND T. J. FOSTER* .................... S912-914 Continued on following page Continued from preceding page Susceptibility Interactions Among Amphotericin B, 5-Fluorocytosine, Ketocona- zole, and Miconazole Against Pathogenic Fungi In Vitro. F. C. ODDS ................................................... 763-770 Bacteroides fragilis Resistance to Clindamycin In Vitro. ANIBAL SOSA, FRANCIS P. TALLY,* NILDA V. JACOBUS, AND SHERWOOD L. GORBACH ................ ............................ 771-774 In Vitro Activity of Azthreonam, a Monobactam Antibiotic. NILDA V. JACOBUS, MARIA C. FERREIRA, AND MICHAEL BARZA* .... 832-838 Effect of Calcium, Magnesium, and Zinc on Ticarcillin and Tobramy- cin Alone and in Combination Against Pseudomonas aerugino- sa. JEFFREY J. ZURAVLEFF, VICTOR L. Yu,* ROBERT B. YEE, M. K. ZAPHYR, WARREN DIVEN, AND FLOYD B. TAYLOR .... 839-843 Cefotetan, a New Cephamycin: Comparison of In Vitro Antimicrobi- al Activity with Other Cephems, P-Lactamase Stability, and Preliminary Recommendations for Disk Diffusion Test- ing. LEONA W. AYERS,* RONALD N. JONES, ARTHUR L. BAR- RY, CLYDE THORNSBERRY, PETER C. FUCHS, THOMAS L. GA- VAN, E. HUGH GERLACH, AND HERBERT M. SOMMERS ....... 859-877 Susceptibility of Bacteroides spp. to Heavy Metals. THOMAS V. RILEY* AND BRIAN J. MEE ....... ........................ 889-892 Activity of Pirlimycin (U57930E) Against Strains of the Bacteroides fragilis Group. J. A. GARCIA-RODRIGUEZ,* J. E. GARCIA-SAN- CHEZ, J. PRIETO, AND A. SANCHEZ DE S. LORENZO .... ..... 893-894 Susceptibility of Clinical Isolates of Staphylococcus saprophyticus to Fifteen Commonly Used Antimicrobial Agents. L. E. NI- COLLE* AND G. K. M. HARDING ...... .................... 895-896 Susceptibility of Group B Streptococci to 16 P-Lactam Antibiotics, Including New Penicillin and Cephalosporin Deriva- tives. MICHAEL R. JACOBS,* FRANCES KELLY, AND WILLIAM T. SPECK ............................................... 897-900 Synergism Between Vancomycin and Gentamicin or Tobramycin for Methicillin-Susceptible and Methicillin-Resistant Staphylococ- cus aureus Strains. CHATRCHAI WATANAKUNAKORN* AND JOANN C. TISONE ........... ............................ 903-905 In Vitro Susceptibility of Methicillin-Resistant and Methicillin-Sus- ceptible Staphylococcus aureus Strains to N-Formimidoyl Thienamycin. JOYCE L. WITTE, FRANCISCO L. SAPICO,* AND HANNA N. CANAWATI ......... .......................... 906-908 Effects of a Vancomycin-Rifampin Combination on Enterococ- Ci. CHATRCHAI WATANAKUNAKORN* AND JOANN C. TISONE 915-916 Antagonism Between Nafciilin or Oxacillin and Rifampin Against Staphylococcus aureus. CHATRCHAI WATANAKUNAKORN* AND JOANN C. TISONE .......... ......................... 920-922 Susceptibility of Haemophilus influenzae Type b to Cefaclor and Influence of Inoculum Size. ROBERT M. LEVIN,* PARVIN H. AZIMI, AND MARY G. DUNPHY ....... ..................... 923-925 Susceptibility of Neisseria meningitidis and Neisseria gonorrhoeae Isolates to N-Formimidoyl Thienamycin. EDWARD J. DUDEK, JANE D. STEPHENSON, MARJORIE BOHNHOFF, AND STEPHEN A. LERNER* ................................................ 926-929 Activity of Nine Antimicrobial Agents Against Lancefield Group C and Group G Streptococci. KENNETH V. I. ROLSTON, JACK L. LEFROCK,* AND RONALD F. SCHELL ...... ................ 930-932 Continued on following page Continued from preceding page Analytical Procedures Assay of Amoxicillin and Clavulanic Acid, the Components of Augmentin, in Biological Fluids with High-Performance Liquid Chromatography. MARK FOULSTONE AND CHRISTOPHER READING* ............................................... 753-762 High-Pressure Liquid Chromatographic Method for Determination of Sch 29482 in Human Serum. H. KIM, E. ODEN, AND C. LIN* 848-851 Evaluation of the Cathra Inoculating Device for Susceptibility Test- ing of Methicillin-Susceptible and Methicillin-Resistant Staphy- lococcus aureus Strains. JOHN M. BOYCE,* MARY C. BONNER, AND W. R. LOCKWOOD ........... ........................ 901-902 Experimental Therapeutics Antibacterial Activities of SM-1652 Compared with Those of Other Broad-Spectrum Cephalosporins. MASUHIRO KATO,* MATSUHISA INOUE, AND SUSUMU MITSUHASHI .... ......... 721-727 In Vitro and In Vivo Antibacterial Activity of T-1982, a New Semisynthetic Cephamycin Antibiotic. M. TAI, Y. FUKUOKA, A. YOTSUJI, K. KUMANO, M. TAKAHATA, H. MIKAMI, T. YASUDA,* I. SAIKAWA, AND S. MITSUHASHI ..... ........... 728-734 Activity of Ketoconazole and Its Deacyl Derivative Against Plasmo- diumfalciparum and Candida Isolates. MICHAEL A. PFALLER, JOSEPH J. SEGAL, AND DONALD J. KROGSTAD* .... ......... 917-919 Pharmacology Two-Compartment Comparison of Gentamicin and Tobramycin in Normal Volunteers. MARTIN ADELMAN, EVAN EVANS, AND JEROME J. SCHENTAG* ........... ........................ 800-804 Pharmacokinetic Characteristics of Intravenous Ceftriaxone in Nor- mal Adults. ALAN A. POLLOCK,* PATRICIA E. TEE, IN- DRAVADAN H. PATEL, JONATHAN SPICEHANDLER, MICHAEL S. SIMBERKOFF, AND JAMES R. RAHAL, JR. ................... 816-823 Role of Serum Protein Binding and Multiple Antibiotic Doses in the Extravascular Distribution of Ceftizoxime and Cefotax- ime. DALE N. GERDING,* LINDA L. VAN ETTA, AND LANCE R. PETERSON ............................................ 844-847 Pharmacokinetics, Protein Binding, and Extravascular Distribution of Ceftizoxime in Normal Subjects. LANCE R. PETERSON,* DALE N. GERDING, LINDA L. VAN ETTA, JOHN H. ECKFELDT, AND TOM N. LARSON ........... ......................... 878-881 Comparative Penetration of Azlocillin and Mezlocillin into Cerebro- spinal Fluid of Normal Rabbits and Rabbits with Experimentally Induced Pseudomonas aeruginosa Meningitis. GLENN R. HODGES* AND SAMUEL E. WORLEY ...... ................. 909-911 Erratum Activity of Cefoperazone Against Ampicillin-Resistant Bacteria in Agar and Broth Dilution Tests. FRITZ H. KAYSER, GIOVANNA MORENZONI, AND FRANSOISE HOMBERGER ..... ............ 933 * Asterisk refers to person to whom inquiries regarding the paper should be addressed..