http://chicagoacs.org NOVEMBER • 2004 CHICAGO SECTION AMERICAN CHEMICAL SOCIETY Joint Meeting of the University of Chicago Department of Chemistry and the Chicago Section ACS Julius Stieglitz Award Lecture, Dinner and Presentation FRIDAY, NOVEMBER 19, 2004 Drury Lane Oakbrook "Illuminating the Structure and Self­ 100 Drury Lane Assembly of Alzheimer's 13-Amyloid Oakbrook Terrace, IL Fibrils " presented by Dr. Robert 630-530-8300 Botto, Chemistry Division , Argonne The English Room National Laboratory See page 2 for more information. DIRECTIONS TO THE MEETING SOCIAL HOUR From the North or South: Take 294 to (Cash Bar): 6:00-7:00 P.M. 1-88 West. Exi t Cermak Rd. (22nd Street). (The exit is just past the toll DINNER 7:00 P.M. booth.) Cross Cermak and proceed north on Spring Road. Continue north Menu: Fresh Fruit Panache ; Spinach on Spring Road. The road jogs left at Mandarin Salad; Steak with Bearnaise 16th Street, but do not go west on 16th. sauce and Vesuvio Potatoes , Baked Bear to right, continue on Spring Road Scrod with long-grain and wild rice Dr. Eloy Rodriguez going north which narrows after this blend , or Vegetar ian Spinach and James A. Perkins Professor of Biolo­ slight jog. Go past Oakbrook Terrace Ricotta Rotolo; buttered broccoli; fresh gy and Natural Products Chemistry Tower to Drury Lane Road, and turn left baked bread and butter; Deep-dish Cornell University, New York (west) into the Hilton Hotels/Drury Lane Dutch Apple Pie with Cinnamon Cream Dinner Theatre Complex. and Caramel Sauce; beverage. Topic: "Chemical Novelty from the Dinner reservations are required and Amazonian Jungles and Caribbean From Downtown: Take 290 West should be received in the Section Office Seas: Playgrounds for Synthetic (Eisenhower) to 1-88West. Exit Cermak via phone (847-647-8405) , fax (847- Organic Chemists and Chemical Rd. Follow the directions above to the 647-8364), email (chicagoacs@ Biologists" hotel. ameritech.net) , or website (http: // ChicagoACS.org) by noon on Tuesday, Abstract: The biosynthesis that leads From the West: Take 1-88 East and November 16. The dinner cost is $30 to to the chemical diversity among simple exit at Midwest Road, turn right , pro­ Section members who have paid their and complex organic molecules in natu­ ceed to Butterfield Road (Route 56) and local section dues, members' families, ral environments is indeed the spice of turn right. Watch closely and follow the and visiting ACS members. The cost to life in the tropical regions of the world. signs to Drury Lane so you don't end up non-Section members is $32. The cost Amazonian spiders , plants, insects, on the wrong road. to students and unemployed members birds and fish continue to evolve novel is $15 . Seating will be available for (continued on page 2) FREE PARKING those who wish to attend the meeting without dinner . PLEASE HONOR NOTICE TO ILLINOIS UNDERGRADUATE RESEARCH YOUR RESERVATIONS. The Section SYMPOSIUM: 4:00-5:00 P.M. must pay for all dinner orders. No­ TEACHERS shows will be billed. The Chicago Section-ACS is an ISBE JOB CLUB: 5:00-5:45 P.M. provider for professional development PRESENTATION OF units for Illinois teachers. Teachers TOPICAL GROUP: 5:30-6:30 P.M. STIEGLITZ LECTURE 8:00 P.M. who register for this month's meeting will have the opportunity to earn up to 5 CPDU's. 11/04 2 (continued from page 1) TOPICAL GROUP SPEAKER Argonne National Laboratory (1995) ; org anic chemical struc t_ures that are National Research Council Research used in animal defense, fitness, mating, Fellow , National Bureau of Standards repulsion and attracti~~- In ma~y ca~es (1979-81); NATO Grant ~w~rd (1977); those molecules inh1b1tkey b1olog1cal Merit Teaching Award , M1ch1ganState processes and with_a skill s~rpassing the University (1973). genius of synthetic organic _chemist:' , He has been a National Tour Speaker various organisms convert highly toxic for the Society for Applied Spectroscopy, molecules into life-savings miracles. a co-organizer of the 5th and 7th lnt'I In this presentation, highlights of drug Conferences on Magnetic Resonance discovery from my laboratories a~ UC Microscopy, session chairman of "Appli­ Irvine, Cornell and the Amazon will be cations of NMR to Complex Systems," at presented. The biological importance of the fall 1999 ACS National Meeting, sym­ complex molecules, ran9ing from ~ma­ posium chairman on "Solid State NMR: zonian derived viagra -llke cocktails to Materials Imaging and Polymer Spec­ apoptosis -inducing (cancer-cell death) troscopy ," at the 1995 Chemical alkalo ids , to those found in chemical Congress of Pacific Basin Societies, U.S. secretion from certain birds, that have Editor Journal of "Solid-State NMR", 1994-present , NMR Symposium chair­ been found to kill parasites , bacte ria Dr. Robert E. Botto man (1993) and co-chairman (199~) for and viruses, will be described. The birds "Illuminating the Structure and Self­ obtain the toxic molecules by ingesting the Rocky Mountain Conference, editor of Assembly of Alzheimer 's ~-Amyloid the ACS Advances in Chemistry Series, poisonous ants as a part of th~ir di~t. Fibrils" The talk will highlight the highly inter­ "Techniques in Magnetic Resonance of disciplinary nature of thi _s resear?h , Carbonaceous Solids," 1993, NMR Labo­ Abstract: Alzheimer's Disease is char­ ratory Director, Chemistry Division, 1990- point ing out the necess1_ty of _using acterized histopathologically by the organ ic chemistry , chemical biology 1995. Dr. Botto has several publications deposition of amyloid plaques, especially and is the co-editor and editor of a num­ and ecology in the important and never­ in areas of neuron loss . The primary ber of books on magnetic resonance. ending search for novel molecu!es that component of these plaques is a 39-43 will cure diseases, relieve suffering and amino acid peptide called P-amylo1d just coincidentally , furni~h great_chal ­ (AP)- Specific interpeptide di~tanc~ con­ REGISTER ONLINE for lenges for synthetic organic chemists . straints are determined with d1polar recoupling NMR on fibrils prepared from Chicago Section Biography: Professor Eloy Rodriguez a series of singly labeled peptides con­ monthy meetings is the James A. Perkins Professo r of taining 13C-carbonyl-enriched amino Biology and Natural Products Chem­ acids, and skipping no more that three istry at Cornell University in New York. residues in the sequence. From these http ://ChicagoACS.org He has published over 160 research studies, we demonstrate that the peptide articles, 2 books and presented invited adopts the structure of an extended par­ lectures throughout the US, Europe , allel p-sheet in-register at pH 7.4. Analy­ In This Issue Latin America and Asia. sis of NMR data indicates interstrand He received his Ph.D. with the organic :features distances of 5.3 ± 0.3 A (mean ± stan­ 1 - Dinner Meeting/Stieglitz chemist Dr.Tom Mabry at the University dard deviation) throughout the ent ire of Texas, Austin in 1975 and conducted Lecture length of the peptide. lntrastr~nd NMR 2 - Topical Group postodoctoral research in the laboratory constraints, obtained from peptides con­ of Dr. G.H.N. Towers at the University of 3 - Job Club taining labels at two adjacent amino 3 - Budget Director's Note British Columbia, Canada. He was visit­ acids, confirm these findings. Using pep­ ing professor in Medici~al Chemistr_y at 4 - Council Report tides with 13C incorporated at the car­ · 5 - WCC Column - UC San Francisco and in the Chemistry bonyl position of adjacent amino acids, Jennifer Holmgren Department at the University of Miami. structural transitions from a-helix to P­ He is currently an endowed Professor 6 - Food Drive sheet were observed at residues 19 and 7 - Julius Stieglitz/Lecturers in Plant Biochemistry and Environmen­ 20 but using similar techniques, no evi­ tal To xi cology at Cornell and h~s 9 - Unemployed? de~ce for a turn could be found in the 9 - CEPA and Globalization trained over 16 Ph.D. students 1n putative turn region comprising residues Chemistry and Chemical Biology of 9 - Chemical Bulletin Ad 25-29. SAXS and SANS were used to Rate Schedule Natural Products. He has also provided characterize long-range order. Implica­ research training to over 350 under ­ 9 - Mentors for Chem Olympiad tions of this extended parallel organiza­ 1O - Gifts Needed graduate students , of which a large tion for AP(10-35) for overall fibril forma­ number have been unde rrepresented 1O - Holiday Party tion , stability , local disorder , and mor­ 11 - Section's Project SEED US minorities and women. phology based upon specific amino acid He is very interested and involved i_n contacts will be discussed. K-8 science education as shown by his In 'Every Issue Biography: Robe rt E. Botto i:' a 1 - Notice to Illinois Teachers creation of KIDS - Kids Investigating chemist/spectroscopistat Argonne Nation­ and Discover ing Scie nce , a program 3 - ChemShorts for Kids al Laboratory. He received his A.B. in 8 - ALMA e-News which is aimed at K-8 students . The Chemistry from Rutgers University and his focus of the program is to develop _criti­ 9 - Free T-Shirts M.S. and Ph.D. in Organic Chemistry from 11 - Contact the Chair cal thinking and a love for chemistry Michigan State University. and biology. His research is funded by 11 -Ad Index Robert has received several honors , 12 - Calendar NIH , NSF , Hughes Medical Inst itute including the Pacesetter Award , and private foundations . 11/04 3 apple pie. Our senses of taste and ~m_ell November, 2004 Vol. 91, No. 9. Pub­ 'CHEM. SHORTS'' are then tricked into thinking that It Is, lished by the Chicago S~ction o~ T~e indeed, apple pie. Because our sen~es American Chemical Society, Editorial can be easily tricked this way, as scien­ Staff: Cherlyn Bradley, Editor; Fran tists we must use sensitive instruments to The Elementary Education Committe_e Kravitz, Copy Editor ; Avrom Litin , accurately measure and ident ify sub­ of the Chicago Section ACS presents this Publications Business Manager.