Contents Editorial Focus on Neutrinos 1 . ORNL is fundamentally strong . Lab in a gold mine looks at matter– 14 antimatter imbalance To the Point ‘Mouse House’ inspires breakthrough Infographic . research, automation aids space fuel 16 . Why is there matter? 2 production, and nickel-78 is ‘doubly magic’ Focus on Data Fundamental Science at ORNL . Cancer research accelerates via 18 deep learning . Fundamentally strong: ORNL dives 6 into basic science Focus on Nuclear Oak Ridge Leadership Computing . ALICE experiment re-creates the 7 . Facility: Tackling big questions with 20 universe’s first split second computation . Superior supercomputer parallelism Center for Nanophase Materials 22 for subatomic particle research 9 . Sciences: Small worlds, big discoveries Focus on Physical Sciences ORNL’s Neutron Science User Quantum materials promise exciting 11 . Facilities: Neutrons unlock the 24 . technologies for energy and mysteries of materials electronics Focus on Neutrons Eugene Wigner Distinguished Lecturer Neutrons and quantum spin liquids: 26 . Yuri Tsolakovich Oganessian 12 . Exploring the next materials revolution Researcher Spotlight . Batteries and fertilizer: A conversation 28 with ORNL chemist Gabriel Veith Why Science? . Young researchers explain 30 Time Warp . Liane Russell, pioneer of fetal rad 32 safety On the Cover ORNL physicist David Radford is using the tiny neutrino to address big questions with an experiment housed at a retired gold mine in South Dakota. ORNL is fundamentally strong ORNL has always been a great place for people exploring big questions. Whether you’re a physicist, a chemist, a materials scientist or the kind of eclectic researcher who’s hard to nail down, the lab provides the resources and environment that encourage pursuit of important answers. In the first place, we value collaboration. Our team approach applies diverse expertise to science’s most difficult prob- lems, tapping assets across the lab and in academia and industry. ORNL offers an array of unique and powerful research tools, including two of the world’s leading neutron facilities (page 11), a diverse collection of microscopes and other instruments for analyzing material atom by atom (page 9), and the nation’s most powerful supercomputer (page 7). In this issue of ORNL Review, we focus on efforts to understand the workings of the universe, from its earliest moments to its tiniest particles. Occasionally this work takes our staff off-site. Physicist David Radford co-leads the Majorana Demonstrator, a lab nearly a mile deep in a retired gold mine in South Dakota that could help explain why the universe has more matter than anti- matter (page 14). In Europe, physicist Tom Cormier leads the American contribution to the ALICE experiment at the Large Hadron Collider. ALICE collides lead nuclei at nearly the speed of light to create quark-gluon plasmas, a state of matter largely unseen since a millionth of a second after the Big Bang (page 20). Quarks and gluons are held together by the strong force, one of the universe’s four fundamental forces. In this issue, you can read about efforts to use Titan to advance the study of the strong force, called quantum chromodynamics (page 22). Titan is also helping to analyze a mountain of cancer data to improve treatments (page 18). Quantum materials governed by the interactions amongst atoms and electrons can have astonishing—and astonishingly useful—properties. We look at ORNL research into these remarkable materials (page 24), including projects focused on specific materials such as superconductors (page 6) and quantum spin liquids (page 12). As always, this issue introduces you to noteworthy scientists, both established in their careers (pages 26 and 28) and just starting out (page 30). We also look back at a note- worthy chapter in our history—in this case the work of ORNL biologists Liane and William Russell, who created the first radiation exposure guidance for pregnant women or those likely to conceive (page 32). This will be my final issue of ORNL Review. After exactly 10 years as ORNL’s director, I am taking on a new role as senior vice president for laboratory opera- tions at Battelle, which operates ORNL in partnership with the University of Tennessee. It has been an honor to serve with the talented staff at ORNL and to have shared in celebrating many successes over the past decade. I look forward to many more accomplishments from this important institu- tion in the years to come. Thomas Mason Laboratory Director Vol. 50, No. 2, 2017 1 TO THE POINT Award-winning research Giant poplar dataset owes a debt to ORNL’s promising for biofuels ‘Mouse House’ ORNL researchers have released the ORNL's historic mouse colony had largest-ever single nucleotide polymor- a prominent role in groundbreaking phism dataset of genetic variations in autoimmune disease research recently poplar trees, information useful to plant recognized by the Royal Swedish scientists as well as researchers in the Academy of Sciences. fields of biofuels, materials science and secondary plant metabolism. The research brought this year’s pres- tigious Crafoord Prize in Polyarthritis to For nearly 10 years researchers with scientists in Japan and the United States DOE’s ORNL-led BioEnergy Science Center “for their discoveries relating to regula- have studied the genome of Populus—a fast- tory T-cells, which counteract harmful growing perennial tree recognized for its immune reactions in arthritis and other economic potential in biofuels production. autoimmune diseases.” ORNL’s Liane Russell played a key role in They released the Genome-Wide Asso- research that led to this year’s prestigious David Galas, who collaborated with ciation Study dataset earlier this year. The Crafoord Prize. Image credit: ORNL U.S. winner Fred Ramsdell, says ORNL’s dataset comprises more than 28 million mammalian genetics program provided latory T-cells and thereby regulates the single nucleotide polymorphisms, or the “crucial piece of evidence” for iden- body's immune responses. SNPs, derived from approximately 900 tifying a gene critical to regulating The Mouse House was initially estab- resequenced poplar genotypes. Each SNP immune responses. lished in the late 1940s to study the represents a variation in a single DNA In a letter applauding Ramsdell’s genetic effects of radiation exposure. The nucleotide, or building block, and can act win, Galas also praised ORNL’s William Russells were both National Academy of as a biological marker, helping scientists and Liane Russell for identifying the Science members and recipients of the locate genes associated with certain char- importance of and maintaining the Enrico Fermi Award for their ground- acteristics, conditions, or diseases. spontaneous mutant strain—called breaking mammalian genetics research, The data “gives us unprecedented “scurfy”—for decades. which included the development of occu- statistical power to link DNA changes to “With remarkable patience and fore- pational radiation dose limits (see “Liane phenotypes [physical traits],” said ORNL sight, they bred this strain for over 40 years. Russell, pioneer of fetal rad safety,” page plant geneticist Gerald Tuskan, who It is still unclear to me how they had the 32)—Bill Cabage presented the data at the Plant & Animal intuition to know that this was an impor- For more information: https:// Genome Conference in San Diego. The tant biological effect and therefore could go.usa.gov/xXcgf results of this analysis have been used to lead to an important gene,” Galas wrote. Gala's letter made its way to Liane Russell, now retired and living in Oak Ridge, and the researchers renewed their correspondence. As Galas noted, the mutation was identified in the early years of the ORNL mutant mouse colony—popularly known as the “Mouse House”—which operated from the late 1940s through 2009. In the more recent research, Galas, Ramsdell and their colleagues marshalled an effort that led to the mapping, cloning and iden- tification of a gene recognized as of critical importance in the future of immunology. Using the ORNL mutant strain, the research group identified the mutated gene in the scurfy mouse—the FOXP-3 Scientists gleaned data from Populus trees in an ORNL greenhouse as part of the largest-ever single gene—that controls the key genes of regu- nucleotide polymorphism dataset of the species' genetic variations. Image credit: ORNL 2 www.ornl.gov/ornlreview TO THE POINT seek genetic control of cell-wall recalci- quantum communication in modern trance—a natural characteristic of plant networking technology. And because the cell walls that prevents the release of team used conventional laboratory equip- sugars under microbial conversion and ment such as common fiber-optic cable inhibits biofuels production. and standard photon detectors, they have brought the technique one step closer to BESC scientists are also using the practical use.—Scott Jones dataset to identify the molecular mecha- nisms controlling deposition of lignin in For more information: https:// plant structures. Lignin, the polymer that go.usa.gov/xX5aH strengthens plant cell walls, acts as a Alan S. Icenhour Jess C. Gehin barrier to accessing cellulose and thereby prevents cellulose breakdown into simple Two elected fellows of As director of CASL, Gehin leads sugars for fermentation.—Stephanie Seay American Nuclear Society advanced modeling and simulation devel- For more information: https:// ORNL researchers Alan S. Icenhour opment focused on bridging the gap go.usa.gov/xX5CB and Jess C.