TAB2 Antibody Cat. No.: 3389 TAB2 Antibody Specifications HOST SPECIES: Rabbit SPECIES REACTIVITY: Human HOMOLOGY: Predicted species reactivity based on immunogen sequence: Rat: (86%), Mouse: (79%) TAB2 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human TAB2. IMMUNOGEN: The immunogen is located within the last 50 amino acids of TAB2. TESTED APPLICATIONS: ELISA, IHC-P TAB2 antibody can be used for detection of TAB2 by immunohistochemistry at 5 μg/mL. APPLICATIONS: Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. TAB2 antibody is human specific. TAB2 antibody is predicted not to cross-react with other SPECIFICITY: TAB proteins. POSITIVE CONTROL: 1) Cat. No. 10-301 - Human Brain Tissue Slide Properties PURIFICATION: TAB2 Antibody is affinity chromatography purified via peptide column. CLONALITY: Polyclonal September 23, 2021 1 https://www.prosci-inc.com/tab2-antibody-3389.html ISOTYPE: IgG CONJUGATE: Unconjugated PHYSICAL STATE: Liquid BUFFER: TAB2 Antibody is supplied in PBS containing 0.02% sodium azide. CONCENTRATION: 1 mg/mL TAB2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one STORAGE CONDITIONS: year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. Additional Info OFFICIAL SYMBOL: TAB2 TAB2 Antibody: CHTD2, MAP3K7IP2, KIAA0733, TGF-beta-activated kinase 1 and MAP3K7- ALTERNATE NAMES: binding protein 2, Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAB-2 ACCESSION NO.: NP_055908 PROTEIN GI NO.: 14149669 GENE ID: 23118 USER NOTE: Optimal dilutions for each application to be determined by the researcher. Background and References TAB2 Antibody: TAB2 is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation NF-kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappaB BACKGROUND: (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy. 1) Takaesu G, Kishida S, Hiyama A, et al. TAB2, a novel adaptor protein, mediates REFERENCES: activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol. Cell 2000; 5:649-58. 2) Maizukami J, Takaesu G, Akatsuka H, et al. Receptor activation of NF-kappaB lingand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol. Cell. Biol. 2002; 22:992-1000. 3) Criollo A, Niso-Santano M, Malik SA, et al. Inhibition of autophagy by TAB2 and TAB3. EMBO J. 2011; 30:4908-20. September 23, 2021 2 https://www.prosci-inc.com/tab2-antibody-3389.html ANTIBODIES FOR RESEARCH USE ONLY. For additional information, visit ProSci's Terms & Conditions Page. September 23, 2021 3 https://www.prosci-inc.com/tab2-antibody-3389.html.