Breed Predispositions to Disease in Dogs and Cats Alex Gough: To loved ones, friends and colleagues, for their enormous support over the last three years. Above all, to my daughter Abigail for lighting up my life. Alison Thomas: To Richard, Tom and Harry for their patience and for giving me the time to tackle this project. Breed Predispositions to Disease in Dogs and Cats SECOND EDITION Alex Gough MA VetMB CertSAM CertVC PGCert MRCVS, Bath Veterinary Group, Bath, UK and Alison Thomas BVSc CertSAM MRCVS, Blue Cross Animal Hospital Victoria, London, UK A John Wiley & Sons, Ltd., Publication First edition published 2004 This edition first published 2010 First edition c 2004 by Blackwell Publishing Ltd This edition c 2010 by Alex Gough and Alison Thomas Blackwell Publishing was acquired by John Wiley & Sons in February 2007. Blackwell’s publishing programme has been merged with Wiley’s global Scientific, Technical, and Medical business to form Wiley-Blackwell. 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Includes bibliographical references. Summary: “This resource brings together all the disparate information on breed-related diseases in a quick-reference format. Breed-by-breed, in one section for dogs and one for cats, both inherited and other prevalent disorders are listed. The final section describes the disorders covered. All information is drawn from high quality sources including research journals and veterinary reference texts with references provided, saving hours of searching through scattered literature. This reference helps veterinary professionals to advise clients on their choice of breed and what problems to look out for”–Provided by publisher. ISBN 978-1-4051-8078-8 (pbk. : alk. paper) 1. Dogs–Diseases. 2. Cats–Diseases. I. Thomas, Alison, 1964- II. Title. [DNLM: 1. Dog Diseases–genetics. 2. Cat Diseases–genetics. 3. Genetic Predisposition to Disease. SF 991 G692b 2010] SF991.G67 2010 636.7089607–dc22 2009048313 A catalogue record for this book is available from the British Library. 1 2010 Contents Foreword ix Introduction xi Basic Genetics xiii Part I: Dogs 1 Aberdeen Terrier 3 Bullmastiff 45 Affenpinscher 3 Bull Terrier 47 Afghan Hound 3 Cairn Terrier 48 Airedale Terrier 5 Cavalier King Charles Spaniel 51 Akita 6 Chesapeake Bay Retriever 54 Alaskan Klee Kai 6 Chihuahua 55 Alaskan Malamute 6 Chin 57 American Bulldog 8 Chinese Crested Dog 57 American Pit Bull Terrier 8 Chinese Shar Pei 57 American Staffordshire Terrier 8 Chow Chow 57 American Water Spaniel 9 Clumber Spaniel 59 Anatolian Shepherd Dog 10 Cocker Spaniel 60 Australian Cattle Dog 10 Collies (Rough and Smooth) 67 Australian Kelpie 11 Coonhound 70 Australian Shepherd Dog 11 Coton De Tulear 71 Australian Silky Terrier 13 Curly Coated Retriever 71 Australian Terrier 13 Dachshund 72 Basenji 13 Dalmatian 76 Basset Hound 14 Dandie Dinmont Terrier 78 Beagle 16 Danish/Swedish Farmdog 78 Bearded Collie 19 Deerhound 78 Beauceron 20 Doberman Pinscher (Dobermann) 78 Bedlington Terrier 21 Dogo Argentino 83 Belgian Shepherd Dog 21 DogueDeBordeaux(French Belgian Tervuren 22 Mastiff) 83 Bernese Mountain Dog 23 Drentse Partrijshond 83 Bichon Frise 24 Dutch Kooiker (Kooikerhondje) 83 Bloodhound 26 English Setter 83 Bolognese 27 English Shepherd 84 Boerboel 27 English Toy Spaniel 84 Border Collie 27 Eskimo Dog 84 Border Terrier 29 Entlebucher Mountain Dog 85 Borzoi 29 Field Spaniel 85 Boston Terrier 30 Finnish Lapphund 85 Bouvier Des Flandres 32 Finnish Spitz 85 Boxer 33 Flat-Coated Retriever 86 Boykin Spaniel 40 Foxhound 86 Briard 40 Fox Terrier 86 Brittany Spaniel 40 French Bulldog 88 Brussels Griffon 41 French Spaniel 89 Bulldog (English) 41 Gammel Dansk Hønsehund 89 v vi Contents German Pinscher 89 Neapolitan Mastiff 142 German Shepherd Dog (GSD Newfoundland 142 or Alsatian) 90 New Zealand Huntaway 144 Glen of Imaal Terrier 98 Norfolk Terrier 144 Golden Retriever 98 Norwegian Buhund 145 Gordon Setter 104 Norwegian Elkhound 145 Great Dane 105 Norwegian Lundehund 146 Great Pyrenees 108 Norwich Terrier 146 Greater Swiss Mountain Dog 108 Nova Scotia Duck Tolling Retriever 146 Greenland Dog 108 Old English Sheepdog 146 Greyhound 108 Otterhound 149 Griffon Bruxellois (Brussels Papillon 149 Griffon) 111 Parson Russell Terrier 149 Havanese 111 Pekingese 149 Hovawart 111 PetitBassetGriffonVendeen 151 Hungarian Kuvasz 112 Pointers 152 Hungarian Puli 112 Polish Lowland Sheepdog Hungarian Viszla 112 (Polski Owczarek Nizinny) 155 Ibizan Hound 113 Pomeranian 155 Irish Red and White Setter 113 Poodle 156 Irish Setter 113 Portuguese Water Dog 162 Irish Terrier 116 Presa Canario (Perro de Presa Irish Water Spaniel 116 Canario or Dogo Canario) 163 Irish Wolfhound 117 Pug 163 Italian Greyhound 119 Puli 165 Italian Spinone (Spinone Italiano) 120 Pyrenean Mountain Dog Jack Russell Terrier 120 (Great Pyrenees) 165 Japanese Akita 121 Red Kelpie (Australian Kelpie) 166 Japanese Chin 123 Rhodesian Ridgeback 166 Japanese Shiba Inu 123 Rottweiler 167 Japanese Tosa 123 Russian Black Terrier 171 Keeshond 123 St Bernard 171 Kerry Blue Terrier 125 Saluki 173 King Charles Spaniel (English Samoyed 173 Toy Spaniel) 126 Schipperke 175 Komondor 127 Schnauzer 175 Kuvasz (Hungarian Kuvasz) 127 Scottish Deerhound (Deerhound) 180 Labrador Retriever 127 Scottish Terrier 181 Lakeland Terrier 133 Sealyham Terrier 183 Lancashire Heeler 133 Shar Pei (Chinese Sharpei) 183 Lapland Dog 133 Shetland Sheepdog 185 Leonberger 134 Shiba Inu (Japanese Shiba Inu) 188 Lhasa Apso 134 Shih Tzu 188 Lowchen 136 Siberian Husky 191 Lundehund (Norwegian Lundehund) 136 Silken Windhound 193 McNab Shepherd 137 Silky Terrier (Australian Silky Maltese 137 Terrier) 194 Manchester Terrier 138 Skye Terrier 194 Mastiff (Old English Mastiff) 139 Sloughi 195 Mexican Hairless 140 Soft-Coated Wheaten Terrier 195 Miniature Bull Terrier 140 Spanish Water Dog 196 Miniature Pinscher 140 Spinone Italiano 196 Munsterlander 141 Springer Spaniel 196 Contents vii Staffordshire Bull Terrier 200 Wachtelhund 203 Sussex Spaniel 201 Weimaraner 203 Swedish Elkhound 202 Welsh Corgi 205 Swedish Lapland 202 Welsh Terrier 207 Tibetan Mastiff 202 West Highland White Terrier 207 Tibetan Spaniel 202 Whippet 210 Tibetan Terrier 202 Yorkshire Terrier 211 Viszla 203 Part II: Cats 215 Abyssinian 217 Havana Brown 227 American Shorthair 219 Himalayan 227 Asian 219 Korat 229 Australian Mist 219 Maine Coon 229 Balinese 219 Manx 230 Bengal 219 Norwegian Forest 230 Birman 220 Oriental 231 British Shorthair 220 Persian 231 Burmese 221 Ragdoll 233 Chartreaux 224 Russian Blue 234 Cornish and Devon Rex 224 Scottish Fold 234 Domestic Longhaired 224 Siamese 234 Domestic Shorthaired 225 Somali 239 Egyptian Mau 227 Sphynx 239 Exotic Shorthair 227 Tonkinese 239 Foreign Shorthair 227 Part III: Disease Summaries 241 Cardiovascular conditions 243 Musculoskeletal conditions 261 Dermatological conditions 245 Neoplastic conditions 267 Endocrine conditions 252 Neurological conditions 271 Gastrointestinal conditions 254 Ocular conditions 277 Haematological/ Renal and urinary conditions 283 immunological conditions 257 Reproductive conditions 285 Infectious conditions 260 Respiratory conditions 286 References 289 Appendix: Genetic test providers 329 A colour plate section falls between pages 158 and 159 Foreword This new edition of Breed Predispositions to Disease in Dogs and Cats provides an update on the previous edition, with the aim of improving accuracy and usefulness to animal health professionals. Through presentation of lists, this book provides an easily accessed source of diagnostic possibilities that is particularly helpful when dealing with an unusual collection of clinical signs or with unfamiliar breeds. Diagnostic errors are far more likely to arise