Table S3a C2 KEGG Geneset Genesets enriched and upregulated in responders (FDR <0.25) Genesets enriched and upregulated in non-responders (FDR <0.25) HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS HSA04640_HEMATOPOIETIC_CELL_LINEAGE HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION HSA04514_CELL_ADHESION_MOLECULES HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY HSA04630_JAK_STAT_SIGNALING_PATHWAY HSA03320_PPAR_SIGNALING_PATHWAY HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 HSA00071_FATTY_ACID_METABOLISM HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY HSA00120_BILE_ACID_BIOSYNTHESIS HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION HSA04020_CALCIUM_SIGNALING_PATHWAY HSA04940_TYPE_I_DIABETES_MELLITUS HSA04512_ECM_RECEPTOR_INTERACTION HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS HSA02010_ABC_TRANSPORTERS_GENERAL HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY HSA04710_CIRCADIAN_RHYTHM HSA04510_FOCAL_ADHESION HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON HSA00410_BETA_ALANINE_METABOLISM HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY HSA04010_MAPK_SIGNALING_PATHWAY HSA00561_GLYCEROLIPID_METABOLISM HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM HSA00590_ARACHIDONIC_ACID_METABOLISM HSA01430_CELL_COMMUNICATION HSA04370_VEGF_SIGNALING_PATHWAY HSA00680_METHANE_METABOLISM HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM HSA04614_RENIN_ANGIOTENSIN_SYSTEM HSA00643_STYRENE_DEGRADATION HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION HSA05218_MELANOMA HSA04540_GAP_JUNCTION HSA00591_LINOLEIC_ACID_METABOLISM HSA04910_INSULIN_SIGNALING_PATHWAY HSA00785_LIPOIC_ACID_METABOLISM HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Table S3b C5 All GO Genesets Genesets enriched and upregulated in responders (FDR <0.1) Genesets enriched and upregulated in non-responders (FDR <0.1) DEFENSE_RESPONSE CHROMOSOME IMMUNE_RESPONSE CHROMOSOMAL_PART IMMUNE_SYSTEM_PROCESS MRNA_METABOLIC_PROCESS HEMOSTASIS RRNA_METABOLIC_PROCESS RESPONSE_TO_WOUNDING CHROMOSOME__PERICENTRIC_REGION EXTRACELLULAR_SPACE REPLICATION_FORK INFLAMMATORY_RESPONSE MITOSIS EXTRACELLULAR_REGION_PART REGULATION_OF_CELLULAR_PH REGULATION_OF_BODY_FLUID_LEVELS NUCLEAR_REPLICATION_FORK CELL_ACTIVATION CONDENSED_CHROMOSOME BLOOD_COAGULATION COAGULATION RESPONSE_TO_EXTERNAL_STIMULUS RHO_GTPASE_ACTIVATOR_ACTIVITY LEUKOCYTE_ACTIVATION RECEPTOR_ACTIVITY EXTRACELLULAR_REGION LYMPHOCYTE_ACTIVATION REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS HEMOPOIETIC_OR_LYMPHOID_ORGAN_DEVELOPMENT HUMORAL_IMMUNE_RESPONSE HEMOPOIESIS IMMUNE_SYSTEM_DEVELOPMENT INTEGRAL_TO_PLASMA_MEMBRANE INTRINSIC_TO_PLASMA_MEMBRANE PEPTIDYL_TYROSINE_MODIFICATION PLASMA_MEMBRANE MONOOXYGENASE_ACTIVITY RAS_GTPASE_ACTIVATOR_ACTIVITY MUSCLE_DEVELOPMENT INTERLEUKIN_BINDING PLASMA_MEMBRANE_PART TRANSMEMBRANE_RECEPTOR_ACTIVITY HEMATOPOIETIN_INTERFERON_CLASS__D200_DOMAIN__CYTOKINE_RECEPTOR_ACTIVITY ANGIOGENESIS SULFUR_METABOLIC_PROCESS CELL_SURFACE_RECEPTOR_LINKED_SIGNAL_TRANSDUCTION_GO_0007166 ANTIGEN_BINDING POSITIVE_REGULATION_OF_IMMUNE_SYSTEM_PROCESS RHODOPSIN_LIKE_RECEPTOR_ACTIVITY INTEGRIN_BINDING G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY POSITIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS T_CELL_ACTIVATION REGULATION_OF_IMMUNE_SYSTEM_PROCESS VASCULATURE_DEVELOPMENT SULFOTRANSFERASE_ACTIVITY PHAGOCYTOSIS CELLULAR_DEFENSE_RESPONSE WOUND_HEALING INTRINSIC_TO_MEMBRANE EXTRACELLULAR_MATRIX LEUKOCYTE_DIFFERENTIATION RESPONSE_TO_BIOTIC_STIMULUS CALCIUM_MEDIATED_SIGNALING G_PROTEIN_COUPLED_RECEPTOR_BINDING GTPASE_ACTIVATOR_ACTIVITY INTEGRAL_TO_MEMBRANE AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY SYSTEM_DEVELOPMENT ANATOMICAL_STRUCTURE_DEVELOPMENT AMINO_ACID_DERIVATIVE_BIOSYNTHETIC_PROCESS OXIDOREDUCTASE_ACTIVITY__ACTING_ON_THE_ALDEHYDE_OR_OXO_GROUP_OF_DONOR S ADAPTIVE_IMMUNE_RESPONSE_GO_0002460 CYTOKINE_BINDING POSITIVE_REGULATION_OF_IMMUNE_RESPONSE PROTEINACEOUS_EXTRACELLULAR_MATRIX CONTRACTILE_FIBER MULTICELLULAR_ORGANISMAL_DEVELOPMENT ACTIVATION_OF_IMMUNE_RESPONSE OXIDOREDUCTASE_ACTIVITY REGULATION_OF_LYMPHOCYTE_ACTIVATION CONTRACTILE_FIBER_PART GROWTH_FACTOR_BINDING IMMUNE_EFFECTOR_PROCESS POSITIVE_REGULATION_OF_RESPONSE_TO_STIMULUS NEGATIVE_REGULATION_OF_MULTICELLULAR_ORGANISMAL_PROCESS CYTOKINE_PRODUCTION PEPTIDYL_TYROSINE_PHOSPHORYLATION INTERLEUKIN_RECEPTOR_ACTIVITY CARBOXYLIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY ADAPTIVE_IMMUNE_RESPONSE ORGANIC_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY ORGAN_DEVELOPMENT REGULATION_OF_HEART_CONTRACTION RHO_GUANYL_NUCLEOTIDE_EXCHANGE_FACTOR_ACTIVITY NON_MEMBRANE_SPANNING_PROTEIN_TYROSINE_KINASE_ACTIVITY REGULATION_OF_PEPTIDYL_TYROSINE_PHOSPHORYLATION ORGAN_MORPHOGENESIS MYOFIBRIL RESPONSE_TO_OTHER_ORGANISM NERVOUS_SYSTEM_DEVELOPMENT VITAMIN_TRANSPORT REGULATION_OF_IMMUNE_RESPONSE LIPID_HOMEOSTASIS LOCOMOTORY_BEHAVIOR POSITIVE_REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS REGULATION_OF_BIOLOGICAL_QUALITY MEMBRANE CYTOKINE_SECRETION G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY RESPONSE_TO_VIRUS TRANSFERASE_ACTIVITY__TRANSFERRING_SULFUR_CONTAINING_GROUPS REGULATION_OF_GENE_SPECIFIC_TRANSCRIPTION POSITIVE_REGULATION_OF_LYMPHOCYTE_ACTIVATION POSITIVE_REGULATION_OF_TRANSLATION ACTIN_FILAMENT_ORGANIZATION AMINE_RECEPTOR_ACTIVITY STEROID_DEHYDROGENASE_ACTIVITY SECOND_MESSENGER_MEDIATED_SIGNALING CELL_RECOGNITION CHEMOKINE_RECEPTOR_BINDING OXIDOREDUCTASE_ACTIVITY L_AMINO_ACID_TRANSMEMBRANE_TRANSPORTER_ACTIVITY POSITIVE_REGULATION_OF_T_CELL_ACTIVATION CHEMICAL_HOMEOSTASIS SMALL_GTPASE_REGULATOR_ACTIVITY ENDOCYTIC_VESICLE REGULATION_OF_T_CELL_ACTIVATION COFACTOR_TRANSPORT BEHAVIOR SUGAR_BINDING ANATOMICAL_STRUCTURE_FORMATION REGULATION_OF_CYTOKINE_BIOSYNTHETIC_PROCESS REGULATION_OF_CYTOKINE_SECRETION CARBOXYLIC_ACID_METABOLIC_PROCESS NEURON_DIFFERENTIATION HOMEOSTATIC_PROCESS PROTEOGLYCAN_METABOLIC_PROCESS JAK_STAT_CASCADE ORGANIC_ACID_METABOLIC_PROCESS AMINO_ACID_AND_DERIVATIVE_METABOLIC_PROCESS STEROID_DEHYDROGENASE_ACTIVITY DEAMINASE_ACTIVITY MEMBRANE_PART REGULATION_OF_ANATOMICAL_STRUCTURE_MORPHOGENESIS CYTOKINE_METABOLIC_PROCESS LYMPHOCYTE_DIFFERENTIATION EXTRACELLULAR_MATRIX_PART PROTEASE_INHIBITOR_ACTIVITY LIPID_TRANSPORT GENERATION_OF_NEURONS NEGATIVE_REGULATION_OF_ANGIOGENESIS AMINE_TRANSMEMBRANE_TRANSPORTER_ACTIVITY REGULATION_OF_G_PROTEIN_COUPLED_RECEPTOR_PROTEIN_SIGNALING_PATHWAY FATTY_ACID_BETA_OXIDATION INTERLEUKIN_1_SECRETION SIGNAL_TRANSDUCTION LIPID_RAFT CHEMOKINE_ACTIVITY CYTOKINE_BIOSYNTHETIC_PROCESS RECEPTOR_BINDING CELL_CELL_ADHESION AMINE_METABOLIC_PROCESS MYELOID_LEUKOCYTE_DIFFERENTIATION GLUTATHIONE_TRANSFERASE_ACTIVITY REGULATION_OF_ANGIOGENESIS SYSTEM_PROCESS RESPONSE_TO_CHEMICAL_STIMULUS IMMUNOLOGICAL_SYNAPSE B_CELL_ACTIVATION ACTIVATION_OF_MAPK_ACTIVITY ICOSANOID_METABOLIC_PROCESS EXTRACELLULAR_STRUCTURE_ORGANIZATION_AND_BIOGENESIS ANATOMICAL_STRUCTURE_MORPHOGENESIS REGULATION_OF_RESPONSE_TO_STIMULUS RECEPTOR_COMPLEX MAPKKK_CASCADE_GO_0000165 COPPER_ION_BINDING MYELOID_CELL_DIFFERENTIATION AMINO_ACID_DERIVATIVE_METABOLIC_PROCESS Table S3c Oxaliplatin Basal in vitro geneset The geneset was enriched and upregulated in the non-responder (FDR <25%) Genes enriched: ADXCRPDRC.12697.C1_s_a t RAB11FIP1 Homo sapiens RAB11 family interacting protein 1 (class I) -2.13973 ADXCRPD.6693.C1_s_at GK5 Homo sapiens glycerol kinase 5 (putative) (GK5) mRNA. -2.00457 ADXCRPD.4652.C1_at FLJ20366 Homo sapiens hypothetical protein FLJ20366 (FLJ20366) mRNA. -1.74485 ADXCRAD_BX503862_at na NULL -1.63943 RDCR489_A06_at LOC728863 PREDICTED: Homo sapiens hypothetical protein LOC728863 (LOC728863) -1.50455 ADXCRAG_BC065304_at DEPDC1 Homo sapiens DEP domain containing 1 (DEPDC1) mRNA. -1.49412 ADXCRIH.301.C1_at na NULL -1.40391 ADXCRAG_BC001557_s_at SMC4 Homo sapiens structural maintenance of chromosomes 4 (SMC4) -1.40388 ADXCRPD.2083.C1_at NCAPG Homo sapiens ligand dependent nuclear receptor corepressor-like -1.39083 ADXCRIH.711.C1_at RAB5A Homo sapiens RAB5A member RAS oncogene family (RAB5A) mRNA. -1.36445 ADXCRIH.2730.C1_s_at SH3D19 Homo sapiens SH3 domain protein D19 (SH3D19) mRNA. -1.34021 ADXCRPDRC.2988.C1_at POLE2 Polymerase (DNA directed) epsilon 2 (p59 subunit) -1.29988 ADXCRPD.2283.C1_at LOC653256 PREDICTED: Homo sapiens similar to RAB member of RAS oncogene -1.26735 ADXCRIHRC.179.C1_s_at NET1 Homo sapiens neuroepithelial cell transforming gene 1 (NET1) -1.24644 ADXCRIH.3632.C1_s_at EMP2 Epithelial membrane protein 2 -1.2335 ADXCRAD_AL541247_at SLC35B3 NULL -1.23243 ADXCRPD.1683.C1_at C10orf57 Homo sapiens chromosome 10 open reading frame 57 (C10orf57) mRNA. -1.22209 ADXCRAG_BC025767_s_at RHPN1 Homo sapiens rhophilin Rho GTPase binding protein 1 (RHPN1) mRNA. -1.21481 ADXCRIHRC.32.C1_at KIAA0101 Homo sapiens KIAA0101 (KIAA0101) transcript variant 2 mRNA. -1.20186 ADXCRAG_NM_001987_at ETV6 Homo sapiens ets variant gene 6 (TEL oncogene) (ETV6) mRNA. -1.19825 ADXCRAD_CN430263_s_at POLD4 NULL -1.19113 ADXCRPD.1683.C1_x_at C10orf57 Homo sapiens chromosome 10 open reading frame 57 (C10orf57) mRNA. -1.18617 ADXCRPD.1045.C1_s_at FBXO45 F-box protein 45 -1.18354 ADXCRAD_CX163692_s_at GAL Homo sapiens galanin (GAL) mRNA. -1.18292 ADXCRAD_CF454650_s_at FAM120A Homo sapiens family with sequence similarity 120A (FAM120A) mRNA. -1.17326 ADXCRAG_BC057824_s_at na NULL -1.15893 ADXCRPD.13858.C1_s_at FLNB