Supplemental table 1: Taxa by Symptom Taxonomy Browser https://www.ncbi.nlm.nih.gov/taxonomy ↑= Enriched (X) = study number ↓= Decreased Taxa reference Phylum Class Order Family Genus Species Actinobacteria Actinobacteria Bifidobacteriales Bifidobacteriaceae Bifidobacterium Bifidobacterium infantis Actinomyces Coriobacteriia Coriobacteriales Coriobacteriaceae Eggerthella Eggerthella lenta Bacteriodetes Bacteriodia Bacteriodales Bacteroidaceae Bacteroides Bacteroides fragilis Muribaculaceae Prevotellaceae Prevotella Rikenellaceae Acetobacteroides Alistipes Rikenella Tannerellaceae Parabacteroides Porphyromonadaceae Firmicutes Bacilli Lactobacillales Lactobacillaceae Lactobacillus Enterococcaceae Enterococcus Dehalobacterium Streptococcaceae Streptococcus Streptococcus anginosus Lactococcus Clostridia Clostridiales Clostridiaceae Clostridium Clostridium histolyticum Hungatella Peptostreptococcaceae Intestinibacter Terrisporobacter Lachnospiraceae Anaerostipes Coprococcus Dorea Lachnospira Roseburia Lachnoclostridium Taxa reference Phylum Class Order Family Genus Species Tyzzerella Oscillospiraceae Oscillibacter Ruminococcaceae Faecalibacterium Ruminococcus Caproiciproducens Oscillospira Anaerotruncus Erysipelotrichia Erysipelotrichales Erysipelotrichaceae Holdemania Coprobacillus Negativicutes Acidaminococcales Acidaminococcaceae Vellionellales Vellonellaceae Veillonella Dialister Tissierellia Tissierellales Peptoniphilaceae Anaerococcus Proteobacteria Betaproteobacteria Betaproteobacteriales Burkholderiales Burkholderiaceae Sutterellaceae Sutterella Alcaligenaceae Deltaproteobacteria Desulfovbrionales Desulfobacteraceae Bilophila Gammaproteobacteria Enterobacterales Enterobacteriaceae Enterobacter Citrobacter Klebsiella Salmonella Shigella Escherichea Pasteurellales Pasteurellaceae Heamophilus Verrucomicrobia Verrucmicrobiae Verrucomicrobiales Akkermansiaceae Akkermansia Akkermansia muciphilia Fusiobacteria Fusobacteriia Fusobacteriales Fusobacteriaceae Symptom Phylum Class Order Family Genus Species Diarrhea ↑ Actinobacteria (9) ↓ Bifidobacteriacaceae ↓ Bifidobacterium (15) (2) (13) (10) ↑Eggerthella (15) ↑Actinomyces (7) ↓Bacteriodetes (9) ↓Bacteroidia (17) ↓Bacteroidales (17) ↓ Bacteroidacaceae (17) (15) ↑ Prevotellacaceae (15) ↑Prevotella (11) ↓Rikenellaceae (15) ↓Parabacteroides (17) ↑Firmicutes (9), (17) ↑Bacilli (17) ↑Lactobacillales (17) ↑Lachnospiraceae (5) ↑Lactococcus (15) ↑Clostridia (17) ↑ Ruminococcacaea ↑Clostridium (9) (5),(15) (11) (13) ↓Intestinibacter (11) ↓Terrisporobacter (11) ↓ Lachnospira (7) ↑Lachnoclostridiu m (11) ↑ Tyzzerella (11) ↑Holdemania (17) ↑Coprobacilius (15) ↑Ruminococcus (13) ↑ Caproiciproducens (11) ↑Oscillospira (15) ↑Anaerotruncus (15) Symptom Phylum Class Order Family Genus Species Proteobacteria ↑ Enterobacteriaceae ↑Escherichea (11) Diarrhea (15) ↑Desulfobacteraceae (15) ↑Shigella (11) ↑Bilophilia (11) ↑ Verrucomicrobia (9) Symptom Phylum Class Order Family Genus Species Abdominal pain Actinobacteria ↓ Bifidobacteriacaceae ↓ Bifidobacterium (15) (2) ↑Egerthella lenta (1) ↑Eggerthella (15) Bacteriodetes ↑Bacteriodales (3) ↓ Bacteroidacaceae (15) ↑Prevotella (11) ↑Bacteroides fragilis(1) ↑ Prevotellacaceae (15) ↓Rikenellaceae (15) Firmicutes ↑Lachnospiraceae (5) ↑Dehalobacterium ↑Streptococcus (1) anginosus (1) ↓ Veillonellaceae (1) ↑Lactococcus (15) ↑Ruminococcaceae (3), (5), (15) ↑Clostridium (11) ↓Intestinibacter (11) ↓Terrisporobacter (11) ↑Lachnoclostridiu m (11) ↑ Tyzzerella (11) ↑ Caproiciproducens (11) ↑Oscillospira (15) ↑Anaerotruncus (15) Symptom Phylum Class Order Family Genus Species Abdominal pain Proteobacteria ↑ Enterobacteriaceae (15) ↑Escherichea (11) ↑Desulfobacteraceae (15) ↑Shigella (11) ↑Bilophilia (11) Verrucomicrobia ↑Akkermansia muciphilia (1) Symptom Phylum Class Order Family Genus Species Indigestion Actinobacteria ↓ Bifidobacterium (2) Symptom Phylum Class Order Family Genus Species Depression Actinobacteria ↑Coriobacteriaceae (14) ↑Bifidobacterium (8) ↓Bacteroidaceae (16) ↓Parabacteroides Bacteriodetes (18) (8) ↓Prevotellaceae (16) (18) ↑Rikenellaceae (16) ↑Porphyromonadaceae (16) Firmicutes ↓Lachnospiraceae (16) ↓ Clostridium (19) (18) ↓Erysipelotrichaceae ↓Faecalibacterium (16) (14) ↓Veillonellaceae (16) ↑ Anaerococcus (19) ↓ Ruminococcaceae (14) (16) (18) ↑Acidaminococcaceae (16) ↓ Proteobacteria (19) ↑Enterobacteriaceae (16)↓Haemophilius (19) ↓Sutterella (19) Symptom Phylum Class Order Family Genus Species Depression Fusiobacteria ↑Fusobacteriaceae (16) Symptom Phylum Class Order Family Genus Species Anxiety Actinobacteria ↑Bifidobacterium (8) ↓Bacteriodetes (17) ↓Bacteroidia (17) ↓Bacteroidales (17) ↓Bacteroidaceae (18)(22)↑Bacteroides (22) ↓Muribaculaceae (22) ↓Parabacteroides (8) (17) ↓Prevotellaceae (18) (22) ↑Tannerellaceae (22) ↑Firmicutes (17) ↑Bacilli (17) ↑Lactobacillales (17) ↑Peptostreptococcacea ↑Hungatella (22) e (21) ↓Lachnospiraceae (18) ↑Lachnoclostridiu ↑Clostridia (17) (22) m (21) ↓ Ruminococcaceae ↑ Tyzzerella (22) (18) (22) ↑Holdemania (17) ↓ Dialister (21) (22) ↓ Faecalibacterium (21) ↑Proteobacteria (22) ↑Enterobacteriales (22)↑Enterobacteriaceae (22)↑Shigella (22) ↑Betaproteobacterial ↑ Burkholderiaceae (22) ↓ Sutterella (21) es (22) ↓ Alcaligenaceae (21) Symptom Phylum Class Order Family Genus Species Sleep Actinobacteria ↓ Bifidobacteriacaceae ↑Eggerthella (15) ↑Egerthella lenta (1) Disturbances (15) Bacteriodetes ↓ Bacteroidacaceae (15) ↑Bacteroides fragilis(1) ↑ Prevotellacaceae (15) ↓Rikenellaceae (15) Symptom Phylum Class Order Family Genus Species Sleep Firmicutes ↓ Veillonellaceae (1) ↑Dehalobacterium ↑Streptococcus Disturbances (1) anginosus (1) ↑Ruminococcaceae (15) ↑Lactococcus (15) ↑Anaerotruncus (15) ↑Oscillospira (15) Proteobacteria ↑ Enterobacteriaceae (15) ↑Desulfobacteraceae (15) Verrucomicrobia ↑Akkermansia muciphilia (1) Symptom Phylum Class Order Family Genus Species Distress Actinobacteria ↓Bifidobacterium infantis (12) Bacteriodetes ↓Bacteroidaceae (18) ↓Prevotellaceae (18) Firmicutes ↑Lachnospiraceae (5) ↑Lactobacillus (12) ↑Clostridium (18) histolyticum (12) ↑Ruminococcacaea(5) ↑Enterococcus (12) (18) ↑Lactococcus (12) Symptom Phylum Class Order Family Genus Species Actinobacteria ↓ Bifidobacterium ↓Bifidobacterium (2) infantis (12) Firmicutes ↑Lactobacillus (12) ↑Clostridium histolyticum (12) ↑Enterococcus (12) ↑Lactococcus (12) No taxa for Reflux Study # 1 Grimaldi et al , 2018 2 Kang et al, 2017 3 Chumpatzi et al, 2014 4 Cruz-Aguliar et al, 2018 5 Peter, Fournier, Keip et al, 2018 6 Huang et al, 2019 7 Hatanaka et al, 2018 8 Okubo et al , 2019 9 Mack et al, 2016 10 Liu, Li, Dai et al, 2017 11 Bryrup et al, 2019 12 Partly et al, 2013 13 Kortekangas et al , 2019 14 Painold et al, 2019 15 Giloteaux et al , 2016 16 Jiang et al, 2015 17 Labus et al , 2017 18 Peter, Fourneir, Durdevic et al, 2018 19 Nguyen et al , 2019 20 Paulsen et al, 2017 21 Jiang et al, 2018 22 Chen et al, 2019.