Message from ISCB 2014 ISCB Accomplishment by a Senior Scientist Award: Gene Myers Christiana N. Fogg1, Diane E. Kovats2* 1 Freelance Science Writer, Kensington, Maryland, United States of America, 2 Executive Director, International Society for Computational Biology, La Jolla, California, United States of America The International Society for Computa- tional Biology (ISCB; http://www.iscb. org) annually recognizes a senior scientist for his or her outstanding achievements. The ISCB Accomplishment by a Senior Scientist Award honors a leader in the field of computational biology for his or her significant contributions to the com- munity through research, service, and education. Dr. Eugene ‘‘Gene’’ Myers of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden has been selected as the 2014 ISCB Accom- plishment by a Senior Scientist Award winner. Myers (Image 1) was selected by the ISCB’s awards committee, which is chaired by Dr. Bonnie Berger of the Massachusetts Institute of Technology (MIT). Myers will receive his award and deliver a keynote address at ISCB’s 22nd Image 1. Gene Myers. Image credit: Matt Staley, HHMI. Annual Intelligent Systems for Molecular doi:10.1371/journal.pcbi.1003621.g001 Biology (ISMB) meeting. This meeting is being held in Boston, Massachusetts, on July 11–15, 2014, at the John B. Hynes guidance of his dissertation advisor, An- sequences and how to build evolutionary Memorial Convention Center (https:// drzej Ehrenfeucht, who had eclectic inter- trees. www.iscb.org/ismb2014). ests that included molecular biology. Myers landed his first faculty position in Myers was captivated by computer Myers, along with fellow graduate students the Department of Computer Science at programming as a young student. He and future bioinformaticians Gary Stormo the University of Arizona. Throughout his remembered his fascination being stoked and David Haussler, was drawn by research career, he has been interested in by a realization and recalls, ‘‘A computer Ehrenfeucht’s curiosity about such basic sequence assembly. ‘‘I first started thinking is a programmable device, and once questions as how to compare DNA about this problem in 1984,’’ he recollected. programmed, is a specific device for doing something that I conceived of. I found this magical.’’ He completed a BS in mathe- Citation: Fogg CN, Kovats DE (2014) 2014 ISCB Accomplishment by a Senior Scientist Award: Gene Myers. PLoS matics at the California Institute of Comput Biol 10(5): e1003621. doi:10.1371/journal.pcbi.1003621 Technology, but his interest in biology Published May 22, 2014 came during his PhD studies at the Copyright: ß 2014 Fogg, Kovats. This is an open-access article distributed under the terms of the Creative University of Colorado in the late 1970s. Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Myers recounted that he initially consid- ered molecular biology as ‘‘a source of Funding: CNF was paid by ISCB to write this article. interesting computational questions.’’ He Competing Interests: The authors have declared that no competing interests exist. was studying computer science under the * E-mail: [email protected] PLOS Computational Biology | www.ploscompbiol.org 1 May 2014 | Volume 10 | Issue 5 | e1003621 ‘‘While I developed many seminal algo- their function to produce tissues of a much, much faster way to get it done.’’ rithms for sequence comparison and given function and shape. Genomes Despite the pros and cons associated search in the ’80s and early ’90s, encode this; how?’’ with both of these settings, Myers feels including BLAST (Basic Local Alignment Myers acknowledged that microscopy that ‘‘private universities or not-for-profit Search Tool), the problem that has and and computational bioimaging are hin- institutions, such as the Max-Planck- continues to fascinate me to this day is dered by limits of image resolution, the Gesselschaft (MPG) that I belong to now, sequence assembly.’’ He is well-known often weak signals produced by imaging are terrific in that there is more flexi- for being one of the authors of the 1990 reagents, and the inability to robotically bility of funding, and thus, it is easier to manuscript that first described BLAST, a control commercial microscopes. Myers take risks and work towards long-term groundbreaking algorithm that is still and his research group are working to visions.’’ used today for sequence comparison. overcome some of these barriers by Myers’s unique contributions to com- This paper is also one of the most cited building their own microscopic devices. putational biology have been recognized papers in scientific literature. He sees this type of work as having the by several awards, including election to the Myers’s deep-seated interest in se- potential to revolutionize medicine. He National Academy of Engineering (2003), quence assembly led him to promote the said, ‘‘Really understanding (in molecular the Association for Computing Machinery idea that whole genome shotgun sequenc- terms) what a cell can do and how what it (ACM) Kannellakis Prize (2002), and the ing, which had been effective in sequenc- does affects its role in a complex tissue or International Max Planck Research Prize ing microbial genomes, could be used on organ will greatly advance medicine and (2004). Bonnie Berger (MIT), chair of the the large and unwieldy human genome. treatment as well as help us understand ISCB Nominating Committee, sees Myers Craig Venter believed in this approach as variation across species and how organ- as an exemplar of the Achievement by a well, and he brought Myers to Celera isms develop.’’ Senior Scientist Award. Berger stated that, Genomics in 1998 during their push to Myers recounted the importance of key ‘‘Myers is one of the founders of the field, sequence the human genome. Myers mentors in the success of his career. Myers bringing his algorithmic expertise to the recalled writing thousands of lines of code met Webb Miller when he was a young most fundamental problems in computa- to build algorithms that could assemble faculty member at the University of tional biology. From his role in creating the vast amounts of sequence data. He Arizona in the early 1980s. The two struck the indispensable and widely used BLAST considers the success of this landmark up a fruitful collaboration that led to many program for basic sequence search, to sequencing project as a highlight of his early papers about sequence analysis. breaking the barrier of sequencing the career. Myers explained, ‘‘Miller helped me human genome, to deciphering what is In 2002, Myers returned to academia in greatly in the early part of my career in coded in DNA, he has launched our a position at the University of California, that he taught me, through example, that discipline. Myers has been a prominent Berkeley’s Center for Integrative Geno- writing can be fun.’’ Myers gained a member of the ISCB community, serving mics. Several animal genomes had been different sort of insight while working for on the Board of Directors, as an ISCB sequenced, and many more were in Venter at Celera. He described Venter as fellow, and as chair and area chair for progress. Myers and others were getting ‘‘a master of the sound bite, and while this numerous ISMB meetings.’’ Alfonso Va- to work on mining the mounting collection may sound trivial, it is actually more lencia, leader of the Structural Computa- of genetic information and developing important than one might think. Much tional Biology group at the Spanish algorithms to compare genomes at an of one’s career success depends on the National Cancer Research Center and unprecedented scale. ability to present one’s ideas in powerful, president-elect of ISCB, also sees Myers as More recently, Myers headed a lab at succinct, clear ways.’’ a stellar representative of the field. Valen- the Howard Hughes Medical Institute Myers believes that mentorship should cia said of this year’s award winner, ‘‘I am (HHMI)’s Janelia Farm Research Cam- be ‘‘about shaping the character of the particularly happy about the election of pus, and in 2012, he moved to Dresden, individual and their understanding of their Gene Myers, since he represents the strong Germany, and became director at the role within the research community.’’ He roots of computational biology in algorith- Max Planck Institute of Molecular Cell starts with himself as he aims to ‘‘do [his] mic and method development. The inten- Biology and Genetics and the Klaus- best to be a good role model, to instill sity with which he lives science, the Tschira chair of the Systems Biology values of integrity, objectivity, and open- originality of his approaches, and the Center. Myers describes that his ‘‘latest ness.’’ He states, ‘‘I see my role as mentor attention he dedicates to the technical focus all started because [he] wish[es], like as simply to create a vibrant intellectual details are characteristics of his work and a many, to ‘decode’ the genome.’’ His work atmosphere that allows my students to great example for our new generations of has evolved into building microscopic blossom.’’ Myers has trained students from bioinformaticians and computational biol- devices and image analysis tools that can varied academic backgrounds throughout ogists.’’ be used to observe and model the inner his career, and he considers that passion as Myers remains fervent and passionate workings of cells and biological systems. well as talent are vital to the success of his about the work he does. He contends that ‘‘Having the genome of an organism trainees. Myers affirmed that ‘‘there is no his upbringing, which included traveling allows one to engage in transgenics on a substitute for passion.’’ the globe with his family, as well as his systematic, genome-wide scale,’’ he ex- Myers has also benefitted by working innate passion for science and mathemat- plained.