JOURNAL OF LABORATORY MEDICINE EDITOR Infectiology and Microbiology: Prof. Dr. med. Parviz Ahmad- German Society of Clinical Chemistry and Laboratory Medicine Nejad; Prov.-Doz. Dr. med. Beniam Ghebremedhin, Institute (DGKL e.V.), Friesdorfer Str. 153, 53127 Bonn, Germany for Medical Laboratory Diagnostics, Centre for Clinical and http://www.dgkl.de/PA100016_EN Translational Research (CCTR), HELIOS University Hospital [email protected] Wuppertal, Witten/Herdecke University, Wuppertal, Germany [email protected]; EDITOR-IN-CHIEF [email protected] Professor emeritus Dr. med. Peter Schuff-Werner Prof. Dr. med. Bernard Weber, Laboratoires Réunis Junglinster, University Rostock Medical Centre Junglinster, Luxemburg [email protected]; [email protected] MDI Laboratories Ltd., Medical Care Centre, Berlin, Germany [email protected] Inflammation and Sepsis: Priv.-Doz. Dr. med. Peter Fraunberger, Central Medical Laboratory Ltd., Feldkirch, Austria ASSOCIATE EDITORS [email protected] Allergy and Autoimmunity: Prof. Dr. Ulrich Sack, Institute of Clinical Immunology and Transfusion Medicine, University Leipzig, Laboratory Management: Prof. Dr. med. Eberhard Wieland, Leipzig, Germany Central Institute of Clinical Chemistry and Laboratory Medicine, [email protected] Katharinenhospital, Stuttgart, Germany Prov.-Doz. Dr. Karsten Conrad, Institute of Clinical Immunology, [email protected] Technische Universität Dresden Medical School, Dresden, Germany [email protected] Molecular-Genetic and Cytogenetic Diagnostics: Dr. med. Hanns-Georg Klein, Center for Human Genetics and Biobanking: Priv.-Doz. Dr. Dr. Michael Kiehntopf Laboratory Medicine Dr. Klein und Dr. Rost, Planegg/Martinsried, Institute of Clinical Chemistry and Laboratory Diagnostics, Jena Germany University Hospital, Jena, Germany [email protected] [email protected] Neurology Laboratory: Prof. Dr. Thomas Weber, Department Clinical Chemistry and Metabolism: Prof. Dr. med. Winfried of Neurology, University Hospital Hamburg, Marienkrankenhaus, März, synlab Services GmbH, Mannheim, Germany Hamburg, Germany [email protected] [email protected] Prof. Dr. Uwe K. Zettl, Department of Neurology, Drug Monitoring and Toxicology: Prof. Dr. med. Werner Neuroimmunological Section, University of Rostock, Rostock, Steimer, Institute of Clinical Chemistry and Pathobiochemistry, Germany Technische Universität München Medical School, Munich, Germany [email protected] [email protected] Oncologie: Prof. Dr. med. Stefan Holdenrieder, Institute Endocrinology: Dr. med. Martin Bidlingmaier, Laboratory of Laboratory Medicine, German Heart Center Munich, Munich, Endocrinology, Munich University Hospital, Munich, Germany Germany [email protected] [email protected] Prof. Dr. Jürgen Kratzsch, Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig University Hospital, Pediatric Laboratory Medicine: Prof. Dr. med. Dr. rer. nat. Leipzig, Germany Klaus P. Kohse, Institute of Laboratory Diagnostics and [email protected] Microbiology, University Hospital Oldenburg, Oldenburg, Germany [email protected] Geriatric Laboratory: Professor emeritus Dr. med. Peter Schuff- Werner, University Rostock Medical Centre Point-of-Care-Testing: Prof. Dr. med. Peter B. Luppa, Institute of [email protected]; Clinical Chemistry and Pathobiochemistry, Technische Universität MDI Laboratories Ltd., Medical Care Centre, Berlin, Germany München Medical School, Munich, Germany [email protected] [email protected] Hematology: Dr. med. Carl Thomas Nebe, Hematology-Laboratory Transfusion Medicine and Immunohematology: Prof. Dr. med. Mannheim, Mannheim, Germany Mariam Klouche, Bremen Hospital Group, Bremen, Germany [email protected] [email protected] Hemostaseology: Priv.-Doz. Dr. med. Matthias Orth, Institute of Laboratory Medicine, Marienhospital Stuttgart, Stuttgart, Germany [email protected] ABSTRACTED/INDEXED IN AGRICOLA (National Agricultural Library); Baidu Scholar; CABI (over 50 subsections); Case; Chemical Abstracts Service (CAS) - CAplus; Chemical Abstracts Service (CAS) - SciFinder; Clarivate Analytics - Journal Citation Reports/Science Edition; Clarivate Analytics - Science Citation Index Expanded; Clarivate Analytics - Web of Science; CNKI Scholar (China National Knowledge Infrastructure); CNPIEC; EBSCO (relevant databases); EBSCO Discovery Service; Elsevier - Biobase; Elsevier - Embase; Elsevier - EMCare; Elsevier - Reaxys; Elsevier - SCOPUS; Elsevier - Text Mining; Gale/Cengage; Genamics JournalSeek; Google Scholar; Japan Science and Technology Agency (JST); J-Gate; JournalGuide; JournalTOCs; KESLI-NDSL (Korean National Discovery for Science Leaders); Meta (formerly Sciencescape); Microsoft Academic; Naviga (Softweco); Primo Central (ExLibris); ProQuest (relevant databases); Publons; PubsHub; ReadCube; SCImago (SJR); Sherpa/ RoMEO; Summon (Serials Solutions/ProQuest); TDNet; TEMA Technik und Management; Ulrich's Periodicals Directory/ulrichsweb; WanFang Data; WorldCat (OCLC). The Journal of Laboratory Medicine is the official journal of the German Society for Clinical Chemistry and Laboratory Medicine (DGKL) and affiliated with the Austrian Society for Laboratory Medicine and Clinical Chemistry (ÖGLMKC). The publisher, together with the authors and editors, has taken great pains to ensure that all information presented in this work (programs, applications, amounts, dosages, etc.) reflects the standard of knowledge at the time of publication. Despite careful manuscript preparation and proof correction, errors can nevertheless occur. Authors, editors and publisher disclaim all responsibility for any errors or omissions or liability for the results obtained from use of the information, or parts thereof, contained in this work. The citation of registered names, trade names, trademarks, etc. in this work does not imply, even in the absence of a specific statement, that such names are exempt from laws and regulations protecting trademarks etc. and therefore free for general use. ISSN 0342-3026 ∙ e-ISSN1439-0477 ∙ CODEN LABOD3 All information regarding notes for contributors, subscriptions, Open access, back volumes and orders is available online at www.degruyter.com/ labmed RESPONSIBLE EDITOR(S) Prof. Dr. med. Peter Schuff-Werner, Medizinisches Versorgungszentrum, Medizinisch Diagnostische Institute (MDI) GmbH, Sonnenburger Str. 70, 10437 Berlin, Germany. Tel.: +49 (030) 44 33 64 200, Fax: +49 (030) 44 33 64 10, E-Mail: [email protected] JOURNAL MANAGER Heike Jahnke, De Gruyter, Genthiner Str. 13, 10785 Berlin, Germany, Tel.: +49 (0)30 260 05 - 220, Fax: +49 (0) 30 260 05 - 325, E-Mail: [email protected] RESPONSIBLE FOR ADVERTISEMENTS top-ad Bernd Beutel, Schlossergässchen 10, 69469 Weinheim, Germany, Tel.: +49 (0)62 01 290 92-0, Fax: +49 (0)62 01 290 92-20, E-Mail: [email protected] © 2018 Walter de Gruyter GmbH, Berlin/Boston TYPESETTING Compuscript Ltd., Shannon, Ireland PRINTING Franz X. Stückle Druck und Verlag e.K., Ettenheim COVER ILLUSTRATION fließendes blut © Sebastian Kaulitzki. Permission to use the image on the cover granted by Fololia LLC. ONLINE ACCESS FOR DGKL MEMBERS http://www.dgkl.de/ - Mitglieder Login Laboratoriumsmedizin / Journal of Laboratory Medicine 2018 | Volume 42 | Issue 4 Contents Editorial Endocrinology Edited by: M. Bidlingmaier/J. Kratzsch Peter Schuff-Werner Challenges of laboratory diagnostics in the Seçkin Özgür Tekeli, Feyza Yağmur Tekeli, Onur Erol, elderly 105 Hamit Yaşar Ellidag, Esin Eren and Necat Yılmaz Serum vitamin D receptor levels in gestational diabetes mellitus 149 Geriatric Laboratory Edited by: P. Schuff-Werner Infectiology and Microbiology Martin Risch, Benjamin Sakem, Lorenz Risch Edited by: P. Ahmad-Nejad/B. Ghebremedhin and Urs E. Nydegger The SENIORLAB study in the quest for healthy elderly Lijuan Fan, Ran Li, Hongyun Li, Jian Zhang patients 109 and Lingyun Wang Detection of CagA, VacA, IceA1 and IceA2 virulent Thomas Weber genes in Helicobacter pylori isolated from gastric Laboratory diagnostics in dementia 121 ulcer patients 155 Gabriele Röhrig, Ingrid Becker, Kai Gutensohn and Thomas Nebe, on behalf of the working group laboratory Online Only: Congress Abstracts diagnostics of the German Society of Hematology and Oncology (DGHO) and the working group anemia in the German Congress of Laboratory Medicine: 15th Annual aged of the German Geriatric Society (DGG) Congress of the DGKL (German Society of Clinical Red blood cell counts and indices in the elderly German Chemistry and Laboratory Medicine) and the 3rd population 131 Symposium on Biomedical Analysis Mannheim, Germany, September 26–29, 2018 eA1 Original Article Christiane Knoepfel, Martine Michel Blanco, Urs Nydegger, Lorenz Risch, Harald Renz and Martin Risch Failure of the holotranscobalamin assay in vitamin B12-deficient patients 141.