Downloaded from orbit.dtu.dk on: Oct 04, 2021 Risk-Based Microbiological Criteria: A Tool To Control Campylobacter Nauta, Maarten; Andersen, Jens Kirk Published in: CHRO 2013 Publication date: 2013 Document Version Publisher's PDF, also known as Version of record Link back to DTU Orbit Citation (APA): Nauta, M., & Andersen, J. K. (2013). Risk-Based Microbiological Criteria: A Tool To Control Campylobacter. In CHRO 2013: 17th International Workshop on Campylobacter, Helicobacter and Related Organisms (pp. 23). University of Aberdeen. http://jmm.sgmjournals.org/content/suppl/2013/08/30/62.Pt_9.DC1/CHROfinal.pdf General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Users may download and print one copy of any publication from the public portal for the purpose of private study or research. You may not further distribute the material or use it for any profit-making activity or commercial gain You may freely distribute the URL identifying the publication in the public portal If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Welcome to CHRO 2013 The University of Aberdeen warmly welcome delegates and invited guests to the 17th International Workshop on Campylobacter, Helicobacter and Related Organisms. This conference returns to Europe for the first time in six years. The CHRO Conference 2013 will be the leading international conference, where cutting edge research meets medicine, industry and policy around the topics of this important group of organisms. This will be a unique opportunity to see the recent ground-breaking developments with these important pathogens at this pivotal time in our knowledge and understanding. The coming together of genomics, epidemiology and basic and systems biology with applied biology and health have underpinned the philosophy of this Conference leading to a number of Themes that thread their way through the proceedings: What have we learnt from 30 years of CHRO research? Which CHRO organisms will be of biggest global concern in 10 years time? How do we minimise the disease burden of CHRO? How will omics and systems biology transform CHRO research and understanding? The organising committee would like to thank all of our Sponsors both here in the UK and internationally for their generous support. Thanks also to our advisors at home and abroad, to the plenary speakers and the session chairs for their time and extensive expertise and advice. The organising committee would like to thank our Event Organisers CPD Services of University of Aberdeen, for their continual support and assistance. Welcome! Ken Forbes Emad El Omar Norval Strachan Georgina Hold Disclaimer This abstract book has been prepared using author supplied copy. Editing has been restricted to some correction of spelling and style where appropriate. No responsibility is assumed for any claims, instructions, methods or drug dosages contained in the abstracts. It is recommended that these are verified independently. i Contents Editorial i PROGRAMME xxi Orals 1 O1 - Advances in risk assessment of campylobacteriosis and their relevance for risk management Arie Havelaar 1 O2 - Helicobacter – Helicobacter pylori infection: past, present and future Emad El-Omar 1 O3 - Campylobacter jejuni - the answer is 42 but what are the questions? Diane Newell 1 O4 - Developments in the understanding of Helicobacter pylori virulence John Atherton 2 O5 - Tackling the human campylobacteriosis epidemic in New Zealand: a summary of 10-years of effort Nigel French 2 O6a - The role of autophagy and inflammasomes in Helicobacter pylori-related gastric cancer Natalia Castano Rodriguez 3 O6b - Diarrheal mechanisms in Campylobacter jejuni enteritis Roland Bücker 3 O7a - The human IL-17/Th17 response to Helicobacter pylori infection Richard Ingram 4 O7b- Inflammasome activation by C. jejuni Lieneke Bouwman 4 O8a - Molecular mimicry between Helicobacter pylori CagA and host proteins: implications for pathogenesis. Anna Roujeinikova 4 O8b - SIGIRR-deficient mice, a novel infection model for the study of innate immune responses to Campylobacter jejuni Martin Stahl 5 O9a - Effects of Helicobacter pylori on host immunity and gut microbiome using the C57/Bl6 mouse model. Sabine Kienesberger 5 O9b - A role for Siglecs in the recognition of Guillain-Barré syndrome-related Campylobacter jejuni strains Astrid P. Heikema 6 O10a - Gastric colonization with a restricted commensal flora replicates the promotion of neoplastic lesions by diverse intestinal flora in the Helicobacter pylori INS-GAS mouse model of gastric carcinogenesis Mark Whary 6 O10b - Campylobacter jejuni at the host pathogen interface: The role of periplasmic chaperones in the biogenesis of outer membrane proteins Shadi Zakai 7 O11a - The Potential of Dextran-Based Glycoconjugates for Development of Helicobacter pylori Vaccine Eleonora Altman 7 O11b - Campylobacter jejuni induces acute non-self-limiting enterocolitis in gnotobiotic IL-10-/- mice via Toll-like-receptor-2 and -4 signalling Markus M. Heimesaat 7 O12a - Use of a novel ex vivo three-dimensional system to define host-microbial interactions with carcinogenic potential. Lydia Wroblewski 8 O12b - Meaningful Dissemination of Community-Driven H. pylori Microbiology Research in Indigenous Arctic Communities Monika Keelan 8 O13a - Campylobacter jejuni infection of infant mice: acute enterocolitis is followed by asymptomatic intestinal and extra-intestinal immune responses Stefan Bereswill 9 O13b - Sticky and Sweet: The Interaction of Campylobacter jejuni and Helicobacter pylori with purified mucins Julie Ann Naughton 9 ii O14a - Intestinal microbiota composition of interleukin-10 deficient C57BL/6J mice and susceptibility to Helicobacter hepaticus-induced colitis Sebastian Suerbaum 10 O14b - CagA-dependent down regulation of microRNA-320 by carcinogenic Helicobacter pylori promotes expression of the cell survival protein, Mcl-1 in vitro and in vivo Jennifer M. Noto 10 O15a - A comprehensive overview of Campylobacter and Helicobacter in de-novo Paediatric Inflammatory Bowel Disease. Richard Hansen 11 O15b - The cytolethal distending toxin of Helicobacter pullorum targets vinculin and cortactin, and triggers formation of lamellipodia in intestinal epithelial cells Armelle Ménard 11 O16a - Particular lipooligosaccharide loci and capsule types co-occur in Guillain-Barré syndrome-associated Campylobacter jejuni strains Astrid P. Heikema 11 O16b - H. pylori CagN, a protein which targets human ubiquitin and related small modifiers Christine Josenhans 12 O17a - A randomized, double-blind, placebo-controlled trial of azithromycin in Campylobacter concisus positive patients with diarrhoea Hans Linde Nielsen 12 O17b - Intestinal microbiota shifts towards elevated commensal Escherichia coli loads abrogate colonization resistance against Campylobacter jejuni in mice Markus M. Heimesaat 13 O18a - Critical role of a putative lytic transglycosylase in β-lactam resistance in Campylobacter jejuni Jun Lin 13 O18b - PgdA deacetylase regulates evasion of host defense mechanisms by Helicobacter pylori that contribute to bacterial persistence Giovanni Suarez 13 O19a - Impact of Rearing Conditions on Arsenic Resistance in Campylobacter spp. Sean Pendleton 14 O19b - Glycosylated moieties’ of Campylobacter jejuni flagella modulate Dendritic Cell IL-10 expression via Siglec-10 receptor engagement Mona Bajaj-Elliott 14 O20 - Helicobacter species of concern: Crystal ball predictions for the next decade. Hazel M. Mitchell 15 O21 - Plenary – Campylobacter Rob Mandrell 15 O22a - What have we learnt of the genus Arcobacter since its description in 1991? Maria José Figueras 15 O22b - Rapid, alignment-free analysis of whole genome sequences of Campylobacter jejuni and Campylobacter coli for molecular epidemiology Arnoud H.M. van Vliet 15 O23a - Improved methodology for the primary culture of Helicobacter pylori from gastric biopsies. Guillermo I. Perez 16 O23b - Recent increase in campylobacteriosis incidence in The Netherlands potentially related to proton-pump inhibitor use Martijn Bouwknegt 16 O24a - Gene-specific PCR analysis of Helicobacter suis in China Jie Liu 17 O24b - Estimating the Financial Burden and Disease Severity of Campylobacter in Scotland Laura MacRitchie 17 O25a - Helicobacter pylori Infection in the Yukon Territory of Canada Monika Keelan 17 O25b - The seasonality of campylobacteriosis: are we missing something? Julie Arsenault 18 iii O26a - Occurrence of Helicobacter suis DNA on porcine slaughterhouse carcasses. Lien De Cooman 18 O26b - Campylobacter ureolyticus: an Emerging Gastrointestinal Pathogen? Monika Koziel 19 O27a - Arcobacter in Humans: Intestinal Colonizer or Pathogen? Anne-Marie Van den Abeele 19 O27b - Genomic surveillance of human Campylobacter isolates obtained over a one year period, from Oxfordshire, UK. Alison J. Cody 20 O28a - Whole genome-based phylogenetic clustering of Helicobacter pylori correlates with geographic origin and virulence factor-based typing schemes Arnoud H.M. van Vliet 20 O28b - Description of the epidemiological pattern of campylobacteriosis in Germany from 2001–2010 Bettina M Rosner 20 O29a - Regulatory RNAs in the pathogenic Epsilonproteobacteria Helicobacter pylori and Campylobacter