New insights into survival trend analyses in cancer population-based studies: the SUDCAN methodology - Supplementary data European Journal of Cancer Prevention, December 2016 Table S1. Finally selected models for trend analyses by country and cancer site Cancer site France Italy Spain Switzerland Belgium Portugal Breast MI4 MI6 a MI6 MI2 MG5 MG3 Cervix uteri M0 ML2 MI1 M0 M0 MI3 Colon MI3 MI6 MI3 MI2 MI3 MI3 Corpus uteri MG1 MG3 MG3 ML1 ML1 MG1 Head-neck MI6 MI3 MG3 MI5 ML4 MG3 Kidney ML1 ML3 ML4 MG1 MI2 M0 Liver MI3 MI6 MI2 MI1 MI4 MI3 Lung MG3 MI6 MI6 MI2 MG3 MI3 Oesophagus MG1 MI6 b MI1 MG2 MG6 MG2 Ovary MI5 MI6 MI3 MG6 MI3 MI2 Pancreas MI6 MI3 ML3 ML2 MI3 MI3 Prostate MI4 MI5 MI5 ML1 MI2 MI3 Rectum MI2 MI1 MG1 MG1 ML2 MI2 Skin melanoma MG1 ML4 ML1 MG4 MG2 MG2 Stomach MG6 MI6 MG1 MG1 ML6 MI2 a The model was extended with 2 knots for g(y) and 2 knots for s(a) and n(a) . b Model MI6 was forced, the initially selected model was MG6. Table S2. Does the effect of the year of diagnosis vary with age? Cancer site France Italy Spain Switzerland Belgium Portugal Breast Yes Yes Yes Yes No No Cervix uteri No effect Yes Yes No effect No effect Yes Colon Yes Yes Yes Yes Yes Yes Corpus uteri No No No Yes Yes No Head-neck Yes Yes No Yes Yes No Kidney Yes Yes Yes No Yes No effect Liver Yes Yes Yes Yes Yes Yes Lung No Yes Yes Yes No Yes Oesophagus No Yes Yes No No No Ovary Yes Yes Yes No Yes Yes Pancreas Yes Yes Yes Yes Yes Yes Prostate Yes Yes Yes Yes Yes Yes Rectum Yes Yes No No Yes Yes Skin melanoma No Yes Yes No No No Stomach No Yes No No Yes Yes Table S3. Does the effect of the year of diagnosis vary with time? (i.e., is the effect non-proportional?) Cancer site France Italy Spain Switzerland Belgium Portugal Breast No Yes Yes Yes Yes Yes Cervix uteri No effect Yes No No effect No effect Yes Colon Yes Yes Yes Yes Yes Yes Corpus uteri No Yes Yes No No No Head-neck Yes Yes Yes Yes No Yes Kidney No Yes No No Yes No effect Liver Yes Yes Yes No No Yes Lung Yes Yes Yes Yes Yes Yes Oesophagus No Yes No Yes Yes Yes Ovary Yes Yes Yes Yes Yes Yes Pancreas Yes Yes Yes Yes Yes Yes Prostate No Yes Yes No Yes Yes Rectum Yes No No No Yes Yes Skin melanoma No No No No Yes Yes Stomach Yes Yes No No Yes Yes Table S4. Non-linear effect of the year in the model selected Cancer site France Italy Spain Switzerland Belgium Portugal a Breast Yes Yes Yes No Yes - Cervix uteri No effect No No No effect No effect - Colon No Yes No No No - Corpus uteri No No No No No - Head-neck Yes No No Yes Yes - Kidney No No Yes No No - Liver No Yes No No Yes - Lung No Yes Yes No No - Oesophagus No Yes No No Yes - Ovary Yes Yes No Yes No - Pancreas Yes No No No No - Prostate Yes Yes Yes No No - Rectum No No No No No - Skin melanoma No Yes No Yes No - Stomach Yes Yes No No Yes - a Not applicable; a non-linear effect was not allowed for Portugal-related analyses because of the short study-period (only 6 years). .