(12) United States Patent (10) Patent No.: US 6,555,547 B1 Pamukcu Et Al

(12) United States Patent (10) Patent No.: US 6,555,547 B1 Pamukcu Et Al

USOO6555547B1 (12) United States Patent (10) Patent No.: US 6,555,547 B1 Pamukcu et al. (45) Date of Patent: Apr. 29, 2003 (54) METHOD FOR TREATING A PATIENT WITH 5,239,083 A 8/1993 Kumazawa et al. NEOPLASA BY TREATMENT WITH A 5,250,535 A 10/1993 Verheyden et al. VINCA ALKALOID DERVATIVE 5,254,571 A 10/1993 Coates et al. 5,358,952 A 10/1994 Moschel et al. (75) Inventors: Rifat Pamukcu, Spring House, PA 5,376,683 A 12/1994 Klar et al. (US); Joseph M. Lobacki, North 5,393,755 A 2/1995 Neustadt et al. s s 5,401.774 A 3/1995 Pamuckcu et al. Wales, PA (US) 5.439,895 A 8/1995 Lee et al. (73) Assignee: Cell Pathways, Inc., Horsham, PA (US) 3. A 19. t cal 5,614,530 A 3/1997 Kumar et al. (*) Notice: Subject to any disclaimer, the term of this 5,614,627 A 3/1997 Takase et al. patent is extended or adjusted under 35 5,674,876. A 10/1997 Gilbert et al. U.S.C. 154(b) by 0 days. 5,696,159 A 12/1997 Gross et al. 5,728,563 A 3/1998 Toshio et al. 5,731,167 A 3/1998 Stracke et al. (21) Appl. 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Eur J Pharmacol, 269: 265–8, 1994. topics and trends in ovarian cancer, Exp. Opin. Invest. Butt, Elke et al., Characterization of cyclic nucleotide phos Drugs 4(12): 1205-1216, (1995).* phodiesterases with cyclic AMP analogs: topology of the Ahlstrom, M., Lamberg-Allardt, C., Regulation of adenos catalytic sites and comparison with other cyclic AMP-bind ine 3',5'-cyclic monophosphate (cAMP) accumulation in ing proteins, Mol. Pharmacol. (1995), 47(2), 340-7. UMR-106 osteoblastlike cells: role of cAMP-phosphodi Cardone, M. H., Salvesen, G. S., Widmann, C., Johnson, G., esterase and cAMP efflux, Biochem. Pharmacol. (1999), and Frisch, S. M. The regulation of anoikis: MEKK-1 58(8), 1335–1340.

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