KAMIYA BIOMEDICAL COMPANY Rev. 091305 PRODUCT DATA SHEET Product: Toll Interacting Protein (TOLLIP/TOLIP) (IN) polyclonal Cat. No.: PC-599 (100 µµµg) Storage and Stability : Store at -20˚C. Aliquot to avoid repeat Background: freeze/thaw cycles. Toll-like receptors (TRLs) are evolutionarily conserved pattern recognition molecules Applications and Suggested Dilutions: resembling the toll proteins that mediate Western blot: use at 1 µg/mL antimicrobial responses in Drosophila. These Immunohistochemistry proteins recognize different microbial products during infection and serve as an important link The optimal dilution for a specific application between the innate and adaptive immune should be determined by the researcher. responses. The TLRs act through adaprot molecules to activate various kinases and Limitations: transcription factors so the organism can For in vitro research use only. Not for use in respond to potential infection. These adaptor diagnostics or in humans. molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR4, Warranty: acting as an inhibitor to TLR activation. This No warranties, expressed or implied, are made negative regulation of TLR signaling may serve regarding the use of this product. KAMIYA to limit the production of pro-inflammatory BIOMEDICAL COMPANY is not liable for any mediators during infection and inflammation. damage, personal injury, or economic loss caused by this product. Molecular Weight: 30 kD kDa Species Reactivity: Human, Rat, and Mouse Host : Rabbit Isotype: IgG Positive Control: Rat brain lysate. Located in cytoplasm and phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products. Immunogen: Rabbit polyclonal TOLLIP antibody was raised against a peptide corresponding to 16 amino acids near the center of human TOLLIP. Format: Antigen Immunoaffinity purified. Provided as solution in a phosphate buffered saline with 0.02% sodium azide. KAMIYA BIOMEDICAL COMPANY , Seattle, WA USA Tel: (206) 575-8068 • Fax: (206) 575-8094 www.k-assay.com [email protected] .