Poster Session A Wednesday, February 17, 2016 5:30 p.m.-7:30 p.m. Regency Ballroom Cancer genomes A001 Estrogen-mediated amplification of enhancers leads to aberrant oncogene expression in advanced ER alpha-positive breast cancer. Tim H.-M. Huang. A002 Amplification and overexpression of the EMSY gene in NSCLC. Ayse N Buyru, Onur Baykara , Bulut Pelin, Mehmet Dalay. A003 Genetic and histological stability of 1p/19q co-deleted gliomas at recurrence. Koki Aihara, Keisuke Ueki, Akitake Mukasa, Hiroyuki Aburatani, Phyo Kim. A004 Acid suppression required to generate gastric carcinoid tumors in mice with deleted Men1 and Somatostatin loci. Sinju Sundaresan, Anthony Kang, Juanita L Merchant. A005 Metastatic pathway-specific transcriptome analysis identifies MFSD4 as a putative tumor suppressor and biomarker for hepatic metastasis in patients with gastric cancer. Mitsuro Kanda, Dai Shimizu, Haruyoshi Tanaka, Satoshi Sueoka, Naoki Iwata, Masamichi Hayashi, Daisuke Kobayashi, Chie Tanaka, Suguru Yamada, Tsutomu Fujii, Goro Nakayama, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Yasuhiro Kodera. A006 Germline PARP4 mutations in patients with primary thyroid and breast cancers. Yuji Ikeda, Kazuma Kiyotani, Poh Yin Yew, Kato Taigo , Kenji Tamura, Kai Lee Yap, Sarah M Nielsen, Jessica L Mester, Raymon H Grogan, Charis Eng, Yusuke Nakamura. A007 Cancer evolution simulation identifies possible principles underlying intratumor heterogeneity. Atsushi Niida, Satoru Miyano. A008 Low-frequency mutational heterogeneity of breast cancer subtypes, including TNBC, revealed by sensitive and quantitative allele-specific PCR analyses. Meagan B Myers, Malathi Banda, Nysia I George, Karen L McKim, Barbara L Parsons. A009 Integrated genomic characterization of non-small cell lung cancer cell lines. Sakae Saito, Ikuko N Motoike, Kengo Kinoshita, Jun Yasuda, Hirofumi Ishii, Masayuki Yamamoto. A010 Using mutational signatures to dissect the role of aristolochic acid in renal cell carcinoma and other cancers. Margaret L Hoang, Chung-Hsin Chen, Pau-Chung Chen, Viktoriya S Sidorenko, Kathleen G Dickman, Byeong Hwa Yun, Masaaki Moriya, Robert J Turesky, Yeong-Shiau Pu, Bert Vogelstein, Nickolas Papadopoulos, Arthur P Grollman, Kenneth W Kinzler, Thomas A Rosenquist. A011 DNA copy number gains in malignant pleural mesothelioma. Masashi Furukawa, Shinichi Toyooka, Tatsuro Hayashi, Hiromasa Yamamoto, Nobukazu Fujimoto, Junichi Soh, Shinsuke Hashida, Kazuhiko Shien, Hiroaki Asano, Keisuke Aoe, Kazunori Okabe, Harvey I Pass, Kazunori Tsukuda, Takumi Kishimoto, Shinichiro Miyoshi. A012 Targeted Next-Generation Sequencing Panel for Detection of Mutations in Breast Cancer. Hsuan-Yu Chen, Yi-Chiung Hsu, Sung-Liang Yu, Huei-Wen Chen, Jeremy J.W. chen, Sheng- Fang Su, Ker-Chau Li. A013 Two-step forward genetic screens in mice identified multiple hepatocellular carcinoma driver genes and a new therapeutic target. Takahiro Kodama, Justin Newberg, Robert Rangel, Michiko Kodama, Kosuke Yoshihara, Nancy Jenkins, Neal Copeland. A014 Genome-wide approach to pediatric pancreatoblastoma. Masafumi Seki, Isobe Tomoya, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Yusuke Sato, Keisuke Kataoka, Yoichi Fujii, Hiromichi Suzuki, Teppei Shimamura, Motohiro Kato, Akihiro Iguchi, Asahito Hama, Tomoaki Taguchi, Yukichi Tanaka, Junya Fujimura, Akiko Inoue, Tsuyoshi Ito, Takao Deguchi, Satoru Miyano, Yasuhide Hayashi, Akira Oka, Seishi Ogawa, Junko Takita. A015 Clonal origin of therapy-related myeloid neoplasms. Koichi Takahashi, Feng Wang, Hagop Kantarjian, Doss Denaha, Erika Thompson, Keyur Patel, Sattva Neelapu, Curtis Gumbs, Yan Wang, Zachary Bohannan, Coutney DiNardo, Simona Colla, Jianhua Zhang, Xifeng Wu, Guillermo Garcia- Manero, Andrew Futreal. A016 Molecular epidemiological analysis of oral cancer in the Indian population reveals region- specific differences in the spectrum of driver mutations and oncogenic pathways. Ravi Gupta, Vedam Laxmi Ramprasad, Kartik Kumaramangalam, Arati Khanna Gupta, Sam Santhosh, Amitabha Chaudhuri. A018 DNA probes in the genetic diagnosis and its prognostic factors of Kazakh esophageal cancer patients. Maidiniyeti Niyazi. A019 Detection of multiple low-frequency mutations by molecular-barcode sequencing. Kei Namba, Shuta Tomida, Ken Suzawa, Hiromasa Yamamoto, Yuho Maki, Junichi Soh, Kazunori Tsukuda, Shinichiro Miyoshi, Shinichi Toyooka. A020 Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma. Satoshi Sueoka, Kanda Mitsuro. A021 TFF1 (Trefoil Factor Family 1) act as tumor suppressor to prevent invasive transformation of pancreatic cancer. Junpei Yamaguchi, Yukihiro Yokoyama, Toshio Kokuryo, Masato Nagino. A022 UHRF2 induced by TGF-β is a new negative regulator of EMT. Tomohiro Iguchi, Msami Ueda, Shinya Kidogami, Hisateru Komatsu, Sho Nambara, Yushi Ogawa, Kuniaki Sato, Qingjiang Hu, Tomoko Saito, Hidenari Hirata, Shotaro Sakimura, Ryutaro Uchi, Naoki Hayashi, Shuhei Ito, Hidetoshi Eguchi, Takaaki Masuda, Koshi Mimori. A023 Defining context-specific genetic vulnerabilities in human cancer cells. Eun Jee Koh, Traver Hart, Jason Moffat. A024 Detection of new pathways for tumor progression to CRPC using computational gene network based on differential gene expression profile. Aiko Sugiyama. A025 When Detecting Somatic Variants in Cancer Genomes, Is it Necessary to Sequence Matched Normal Tissue?. Michael James Clark, Elena Helman, Sean Michael Boyle, Ravi Alla, Selene Virk, Deanna Church, Shujun Luo, Gabor Bartha, Jason Harris, Nan Leng, Christian Haudenschild, Martina Lefterova, Massimo Morra, Sarah Garcia, Richard Chen, John West. A026 p53 regulates cancer cell migration and invasion through FOXF1. Takashi Tokino, Miyuki Tamura, Masashi Idogawa, Yasushi Sasaki. A027 A 3D imaging platform to stratify and monitor patients based on their level of genomic instability. Sabine Mai, Cheryl Taylor-Kashton, Celina Li, Doris Chang, Chirawadee Sathitruangsak, Julius A Awe, Jeff Saranchuk, Darrel Drachenberg, Rami Kotb, Hans Knecht. A028 Genetic difference between multicentric carcinogenesis and intrahepatic metastasis of hepatocellular carcinoma. Yutaka Midorikawa, Shogo Yamamoto, Kenji Tatsuno, Hiroki Ueda, Shingo Tsuiji, Genta Nagae, Tadatoshi Takayama, Hiroyuki Aburatani. DNA damage and repair A029 Proteomics of site-specific ADP-ribosylation profiling of DNA-dependent PARPs and histones.. Jean-Philippe Gagne, Marie-France Langelier, Amanda A Riccio, John M Pascal, Daniel Figeys, Guy G Poirier. A030 Estrogen induces RAD51C expression and localization to sites of DNA damage.. Marina K Holz. A031 Oxypeucedanin-mediated Growth Inhibition by G2/M Phase Cell Cycle Arrest in Human Hepatoma SK-Hep-1 cells. So Hyun Park, Ji-Young Hong, Jinwoong Kim, Sang Kook Lee. A032 Roles of RUNX proteins in DNA damage repair. Vaidehi Krishnan, Lavina Tay, Yoshiaki Ito. A033 In vivo and in vitro studies investigating the use of acetaminophen as a cisplatin chemo- sensitizing agent. Alexander Neuwelt, Tam Nguyen, Jeffrey Wu, Leslie Muldoon, Edward A Neuwelt. A034 Epigenetic dysregulation of satellite RNAs expression in senescent cells. Akiko Takahashi, Yoshinori Imai, Eiji Hara. A035 Hypoxia suppresses DNA repair in colon cancer stem cells which sensitizes them to hypoxia-activated pro-drugs. Jennifer Jongen, Kari Trumpi, Lizet van der Waals, Onno Kranenburg, Inne Borel Rinkes. A036 Sensing and signaling of DNA damage by master checkpoint kinase ATM and ATR. Bunsyo Shiotani, Hitoshi Zembutsu. A037 BRCA status prediction in breast cancer by gamma-tubulin immunofluorescence. Gou Watanabe, Chiba Natsuko, Tadashi Nomizu, Akihiko Furuta, Minoru Miyashita, Hiroshi Tada, Akihiko Suzuki, Takanori Ishida, Noriaki Ohuchi. A038 Search for Lynch-syndrome patients by screening of sporadic cases of endometrial cancer; expression analysis of mismatch-repair genes both in early and advanced lesions. Harumi Saeki, Kazunori Kajino, Okio Hino. A039 Functional effects of mutL-alpha genes on prostate cancer cell. Shinichiro Fukuhara, Yozo Mitsui, Ryan K Wong, Mitsuho Imai-Sumida, Soichiro Yamamura, Shahana Majid, Sharanjot Saini, Varahram Shahryari, Guoren Deng, Rajvir Dahiya, Hiroaki Shiina, Norio Nonomura, Yuichiro Tanaka. Epigenetics A040 Hookah Smoke Induces Epigenomic Alterations and Gene Expression Profiles Similar to those Mediated by Cigarette Smoke in Normal and Immortalized Human Respiratory Epithelia and Lung Cancer Cells. Yin Xiong, Sichuan Xi, Jigui Shan, Elvin Hekimoglu, Mary Zhang, Said Azoury, Julie A Hong, David S. Schrump. A041 Novel phosphorylation of CENP-A contributes to chromosomal instability and cancer progression. Mamoru Takada, Weiguo Zhang, Aussie Suzuki, Taruho Kuroda, Zhouliang Yu, Hiroyuki Inuzuka, Christopher Fry, Guohong Li, David Pellman, GARY KARPEN, Wenyi Wei, Qing Zhang. A042 Invention of DNA methylation markers for diagnosis of pancreatic cancer. Keiko Shinjo, Keisuke Katsushima, Genta Nagae, Hiroyuki Aburatani, Kenji Yamao, Yutaka Kondo. A043 Critical roles of the c-Myb/c-Kit pathway in maintenance of leukemia stem cells. Yukiko Aikawa, Issay Kitabayashi. A044 Epigenome landscape of human normal purified hepatocytes and genome-epigenome interaction: analysis by the International Human Epigenome Consortium (IHEC). Eri Arai, Fumihito Miura, Yasushi Totoki, Satoshi Yamashita, Ying Tian, Masahiro Gotoh, Hidenori Ojima, Hiroyuki Nakagawa, Yoriko Takahashi, Hiromi Nakamura, Natsuko Hama, Mamoru Kato, Hiroshi Kimura, Yutaka Suzuki, Takashi Ito, Tatsuhiro Shibata, Yae Kanai. A045 DNA methylation