Anti-MTA2 monoclonal antibody, clone NUB3-387 (DCABH-8980) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Mouse monoclonal to MTA2 Antigen Description The p53 tumor suppressor gene integrates numerous signals that control cell life and death. There are several proteins that are involved in the p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and MTA2. The transcriptional activity of p53 is modulated by protein stability and acetylation. MTA2, also termed MTA1L1, was found to be a subunit of nucleosome remodeling and deacetylating (NuRD) complex. MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by MTA2 represses p53 dependent transcriptional activation and modulates p53 mediated cell growth arrest and apoptosis. MTA2 is ubiquitously expressed in human tissues. Immunogen Synthetic peptide: RRAARRPNLPLKVKPT conjugated to KLH, corresponding to amino acids 626-641 of Human MTA2 Isotype IgG1 Source/Host Mouse Species Reactivity Mouse, Rat, Hamster, Cow, Dog, Human, Monkey Clone NUB3-387 Purification This antibody is a purified IgG. Conjugate Unconjugated Applications ELISA, WB, IP, ICC/IF Positive Control ICC/IF: HEK-293T cells transfected with MTA2 expression vector WB: 293T total cell extract. Format Liquid Size 100 μl Buffer Preservative: 15mM Sodium Azide; Constituents: 10mM PBS, pH 7.4 Preservative 15mM Sodium Azide Storage Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved / thaw cycles. GENE INFORMATION Gene Name MTA2 metastasis associated 1 family, member 2 [ Homo sapiens ] Official Symbol MTA2 Synonyms MTA2; metastasis associated 1 family, member 2; metastasis associated gene family, member 2 , MTA1L1; metastasis-associated protein MTA2; MTA1 L1; MTA1-L1 protein; metastasis- associated 1-like 1; metastasis-associated protein 2; metastasis -associated gen Entrez Gene ID 9219 Protein Refseq NP_004730 UniProt ID A0A024R534 Chromosome Location 11q12-q13.1 Pathway EGFR1 Signaling Pathway, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem; Function RNA polymerase II transcription factor binding; histone deacetylase activity; metal ion binding; protein binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; transcription factor binding transcription factor 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.