6th Annual Translational Medicine Conference ‘Personalising Health and Care’ Date: 25th and 26th September 2014 | Venue: City Hotel, Derry/Londonderry, N.Ireland, UK 1 6th Annual Translational Medicine Conference City Hotel, Derry/Londonderry, Northern Ireland 25th - 26th Sept 2014 Conference Sponsors 2 6th Annual Translational Medicine Conference City Hotel, Derry/Londonderry, Northern Ireland 25th - 26th Sept 2014 Contents Page Conference Programme .................................................................................... 4 Biographies .......................................................................................................... 6 - 9 Delegate List ........................................................................................................ 10 - 12 Bio-Entrepreneur Programme........................................................................ 13 About C-TRIC ....................................................................................................... 14 - 15 Abstracts Poster Presentations................................................................. 16 - 42 Abstracts Oral Presentations................................................................. 43 Abstracts Poster List................................................................. 44 3 6th Annual Translational Medicine Conference City Hotel, Derry/Londonderry, Northern Ireland 25th - 26th Sept 2014 ‘Personalising Health and Care’ - Conference Programme Day One Thursday 25th Sept 1:00 pm Registration and Tea/Coffee 4.30 pm Oral Presentations Parallel Sessions 2:00 pm Welcome and Opening Address Brenda Stevenson, Mayor of Derry Chaired by Chaired by Prof Tony Bjourson, Dr David Brownlee, HSC 2:05 pm Barry Henderson, Business Development Director, Biomedical Innovations Manager, C-TRIC Sciences Research ‘Supporting R&D in Personalised Health and Care’ Institute & Director, Northern Ireland 2:15 pm Dr Penny Wilson Innovation Platform Lead for Stratified Medicine Centre, University of Stratified Medicine, TSB, UK Ulster ‘Supporting Translational Medicine and Healthcare Innovation in the UK’ 5.00 pm Stratified/Precision Technology & novel 2.35 pm Supporting Life and Health Sciences in NI & ROI Medicine 1 approaches….1 Dr Clive Wolsley, Health & Social Care (R&D 5.15 pm Stratified/Precision Technology & novel Division), Public Health Agency Medicine 2 approaches….2 Sam Kinghan, Invest Northern Ireland 5.30 pm Stratified/Precision Technology & novel Patricia McCrory, EU Thematic Lead (Health), Medicine 3 approaches….3 Queen’s University of Belfast 5.45 pm Stratified/Precision Technology & novel 2.55 pm Break for Tea/Coffee - Poster Viewing Session Medicine 4 approaches….4 6.00 pm Stratified/Precision Technology & novel 3.25 pm Dr Jonathan Berg, Consultant Clinical Medicine 5 approaches….5 Biochemist, Sandwells and West Birmingham Hospitals, NHS Trust, UK 6.15 pm Close ‘TPMT shows the way for routine pharmacogenomics; let’s understand why it 6.45 pm Drinks Reception/ Poster Viewing Session has been accepted into routine clinical practice’ 7.45 pm Conference Dinner 3.55 pm Dr David McEneaney, Director of the Cardiovascular Research Unit, Craigavon Area Guest Speaker Hospital Joanne Stuart, NI Science Park Foundation ‘Cardiology Futures’ Ltd (Director) 4 6th Annual Translational Medicine Conference City Hotel, Derry/Londonderry, Northern Ireland 25 - 26th Sept 2014 Conference Programme Continued... Day 2 Friday 26th Sept 1.40pm Prof Steven 1.30pm Barney Devine & David 8:30 am Registration Pennington Bolton, Word on the Ground Professor of ‘Using technology to better 9.05 am Dr Mark Beggs, Associate Director / Chief Proteomics, manage Post Traumatic Stress Operating Officer of Stratified Medicine University College Disorder (PTSD)’ Dublin, Ireland Scotland Innovation Centre ‘Development of a ‘Stratified Medicine Scotland – a National blood based protein Enterprise for Precision Medicine’ signature to stratify patients for prostate 9.35 am Professor Charles Abraham, Professor of cancer treatment. Psychology Applied to Health, University From Discovery to Clinical Diagnostics’ of Exeter ‘The Role of Behaviour Change Intervention Design 2.00pm Dr Nicholas Orr 1.45pm John Dinsmore, Health Team Leader, Innovation Lead, Centre and Evaluation in Translational Medicine’ Institute of Cancer for Practice and Healthcare Research, UK Innovation, Trinity College 10.05 am Coffee Break/ Poster Viewing Session ‘The role of genetics Dublin and genomics ‘The BREATHE Project: A study 10.20 am Ravi Rao, VP, Medicines Development in personalised of the development and use Leader and Head Unit Physician, Immuno- approaches to breast of assisted living technology inflammation Therapy Area Unit, GSK cancer prevention by informal care givers and ‘Developing new medicines: learning to take them and treatment’ people living with chronic health conditions’ personally’ 2.00pm Peter Donnelly, Chief 10.50 am Peter Weber, Professor of Nutrition, DSM Executive, BioBusiness Ltd. ‘Healthcare Technology & Nutritional Products Ltd, Switzerland Apps: Regulatory Issues’ ‘Personalising Micronutrient Intakes to benefit Human Health: Emerging Science & Consumer 2.15pm Q&A Needs’ 2.25pm Close 2.25pm Close 11.20 am Dr Hanne Albert, St Bartholomew’s 2.30pm Poster Viewing Session Hospital, UK ‘Curing Back Pain Using Antibiotics’ Better Data, Better Health, Better Care Session title TBC Lunch 12.00 - 1.00 Buffet Lunch/Poster Viewing 3.00pm Mr David Bingham Chief Executive, Business Services Organisation, NI 1.00 – 2.30 – Breakout Sessions ‘Honest Broker Service - its Role in Better Care’ Chaired Dr Maurice O’Kane Chaired Prof Jonathan Wallace, by Director R&D by University of Ulster 3.15pm Stephen Lusty, JAG’L Consulting Western Health and Tech & novel approaches ‘Building Northern Ireland’s Healthcare Social Care Trust for improved disease Analytics Capability’ Personalised/ prevention, management & Stratified Medicine patient care 3.30pm Professor Siobhan O’Neill, Psychology 1.00pm Chris Roche Chief 1.00pm Peter Devine, Head of Business Research Institute, University of Ulster Commercial Officer, Development, Intelligent ‘Using Data to Improve Outcomes in Mental Aridhia, UK Systems Research Centre, Illness and Suicide Prevention’ ‘Why Personalised University of Ulster Medicine is a Long ‘Using novel technologies, 3.45pm Panel discussion chaired by Trung Do - Tailed Business devices and intelligent Model’ systems towards improved Executive Director of Business Development healthcare’ at Partners Healthcare 1.20pm Dr Des Brennan, Life 1.15pm Kieran Daly, Chair of Sciences Interface BioBusiness 4.00pm Results of Poster Competition and Closing Group, Tyndall ‘The use of technology Remark Institute towards personalised ‘Emerging healthcare’ technology platforms 4.10pm Close for near patient genetic analysis 5 for personalised medicine’ BIOGRAPHIES Professor Charles Abraham Professor Charles Abraham is a social and health psychologist. His research focuses on improving the design and evaluation of interventions to change health behaviour patterns. The aim of his research is to optimise translation of research findings into improved healthcare practice. He employs a range of quantitative and qualitative methods and collaborates widely. He is Head of the Psychology Applied to Health (PAtH) group in the University of Exeter Medical School. The PAtH group consists of 5 core faculty, 8 research fellows and 10 doctoral students. He also hold honorary positions at Sussex, Maastricht, Nottingham and Curtin universities. He has investigated a wide range of behaviour patterns including exercise, diet, alcohol use, condom use, smoking cessation, blood and organ donation and management of chronic illnesses. He has developed and evaluated effective interventions to promote health-enhancing behaviours in a range of contexts from schools in South Africa to “Weight Watchers” classes in Poland. Charles Abraham is a practising, health psychologist (registered by the UK Health and Care Professionals Council) and between 1997 and 1999, he was the founding chair of the British Psychological Society Division of Health Psychology. In this role he led a team of psychologists who established the accreditation systems used to regulate health psychology practitioners in the UK. In 2003-2004 he was employed as a consultant in the UK Department of Health and in 2014, he was one of seven psychologists included in a list of the leading 100 practising scientists in the UK; a list generated for the first time by the UK Science Council. In the UK the National Institute for Health and Care Excellence (NICE) sets standards for quality healthcare and produces guidance on medicines, treatments and procedures. Charles Abraham has served on two NICE guidance development groups on health behaviour change in 2003/4 and 2012/13. In 2011/12 he served as scientific advisor to House of Lords Select Committee on Science and Technology, Inquiry into Behaviour Change which made 32 recommendations to government including advocating greater investment in evaluation of interventions. Dr Mark Beggs Dr Mark Beggs is Chief Operating Officer for Stratified Medicine Scotland based in Glasgow UK. SMS-IC is an Industry, Academia, NHS collaboration developing a commercial capability in Stratified Medicine. SMS-IC is based in Scotland, UK and capitalises on a strong academic research base in major disease areas coupled with unique NHS e-Health Records and industrial quality NextGen Sequencing and hosted analytics capabilities provided